期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 16, 期 17, 页码 7908-7920出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.07.079
关键词
polyfunctionalized quinolines; synthesis; Lewis acid-catalyzed imino Diels-Alder reactions; antifungal properties
资金
- COLCIENCIAS
- Agencia de Promocion Cientifica y Tecnologica de Argentina (ANPCyT) [PICTR 260, PICT 995]
- CONICET
Diverse polyfunctionalized quinolines, easily prepared using Lewis acid-catalyzed imino Diels-Alder reactions between corresponding aldimines, were tested for antifungal properties against standardized as well as clinical isolates of clinically important fungi. Among them, 4-pyridyl derivatives displayed the best activities mainly against dermatophytes. The activity appears not to be related neither to the lipophilicity nor to the basicity of compounds. (C) 2008 Elsevier Ltd. All rights reserved.
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