期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 16, 期 10, 页码 5441-5451出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.04.009
关键词
ene-yne; non-conjugated; DNA cleavage; thermal cyclization; cycloaromatization; Escherichia coli (E. coli) transformation; atomic force microscopy (AFM)
Water-soluble non-conjugated thienyl tetraynes (3-6) were synthesized and their DNA cleaving activity was evaluated using electrophoresis, atomic force microscopy (AFM) and Escherichia coli ( E. coli) transformation techniques. The amino-functionalized compound 4 was shown to possess an activity to cleave plasmid DNA by both electrophoresis and E. coli transformation techniques. AFM also showed a cleavage of the circular DNA into a linear form with a formation of burst-star-shaped architectures, which were envisaged to be cross-linked DNA oligomers. (C) 2008 Elsevier Ltd. All rights reserved.
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