Review
Biochemistry & Molecular Biology
Kayla Jaye, Dennis Chang, Chun Guang Li, Deep Jyoti Bhuyan
Summary: This review evaluates the anticancer activity of metabolites produced by the gut microbiota against breast cancer. Several metabolites, such as butyrate and inosine, have shown potential in their anticancer effects. However, the mechanisms and dose-response relationship for breast cancer are not well-established and require further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Yangbo Li, Pengzhan He, Yinghui Liu, Mingming Qi, Weiguo Dong
Summary: The combination of sodium butyrate and cisplatin increased apoptosis of GC cells and effectively inhibited tumor growth in a nude mouse xenograft tumor model. This combination also elevated intracellular ROS, reduced MMP, and suppressed invasion and migration abilities of GC cells. Western blotting confirmed enhanced levels of mitochondrial apoptosis-related pathway proteins.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Engineering, Environmental
Dongfang Xue, Yating Cheng, Tiantian Pang, Yunyi Kuai, Yu An, Kuntan Wu, Yuqing Li, Mengyu Lai, Bihan Wang, Shuai Wang
Summary: This study investigated the protective effects of sodium butyrate (NaB) on the porcine intestinal barrier against deoxynivalenol (DON) exposure. NaB supplementation mitigated the damage to mitochondrial morphology and disrupted gut epithelial tight junctions caused by DON. In cell experiments, NaB efficiently repaired the intestinal epithelial barrier. The improvement of mitochondrial function through PCK2-mediated glyceroneogenesis and restoration of mitochondrial structure was involved in the repair of the intestinal barrier. These findings highlight the potential of NaB in protecting against DON-induced gut epithelial tight junction disruption in piglets.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Oncology
Manvi Sharma, Trygve O. Tollefsbol
Summary: Dietary phytochemicals have the ability to prevent cancer by regulating the epigenome. Some natural botanicals, when combined at optimal concentrations, can synergistically decrease cellular viability and inhibit tumor growth in breast cancer cell lines. These combinations also down-regulate the levels of enzymes involved in epigenetic modifications and induce global changes in chromatin modifications. This study suggests that combined use of these dietary compounds may have implications in breast cancer therapy.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biology
Burcu Yuksel, Asuman Deveci Ozkan, Duygu Aydin, Zeynep Betts
Summary: This study evaluated the biochemical and genotoxic changes in cell death control caused by NaBu treatment in breast cancer cells. The results showed that NaBu inhibited cell proliferation and affected antioxidant enzymes and oxidative stress parameters, leading to increased DNA damage.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ziwei Wang, Wan Shu, Rong Zhao, Yan Liu, Hongbo Wang
Summary: Sodium butyrate can promote the expression of RBM3 and indirectly downregulate the expression of SLC7A11 to stimulate ferroptosis in endometrial cancer cells. This study found that sodium butyrate can inhibit the progression of endometrial cancer in vitro and in vivo, and may be a promising cancer treatment strategy.
Review
Immunology
Karolina Kazmierczak-Siedlecka, Luigi Marano, Elvira Merola, Franco Roviello, Karol Polom
Summary: Accumulating evidence suggests that microbiota-derived metabolites, such as butyrate, play a significant role in tumor prevention and cancer treatment. Butyrate has a wide range of beneficial properties, including influencing the immune system, maintaining intestinal barrier integrity, and enhancing anti-cancer treatment efficiency. Sodium butyrate, as a potential option for colorectal cancer patients, can be obtained through food with special medical purposes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Yong-Guo Zhang, Yinglin Xia, Jilei Zhang, Shreya Deb, Shari Garrett, Jun Sun
Summary: The microbiota plays a critical role in regulating intestinal and extraintestinal health. This study investigates the potential connection between the intestinal microbiome and breast cancer. Through the examination of mice with VDR deficiency and dysbiosis, the researchers found that VDR deficiency leads to an increased susceptibility to breast cancer. Moreover, they identified the mechanisms by which VDR deficiency disrupts gut health and increases the risk of breast tumorigenesis. Treatment with beneficial bacteria or their metabolites showed promising results in reducing breast tumors and improving gut health.
Article
Oncology
Zhongbo Bian, Xiaodie Sun, Lulin Liu, Yong Qin, Qiuyu Zhang, Huahuan Liu, Lianzhi Mao, Suxia Sun
Summary: NaB induces ferroptosis in colorectal cancer cells through the CD44/SLC7A11 signaling pathway and shows synergistic effects when combined with Erastin. These findings provide new insights into the prevention and treatment of colorectal cancer.
Article
Plant Sciences
Oscar Martinez, Veronica Arjones, Maria Victoria Gonzalez, Manuel Rey
Summary: The use of an induction medium containing histone deacetylase inhibitors, like sodium butyrate, improved the embryogenic responses in grapevine cotyledonary and recently germinated somatic embryos. The study also showed significant overexpression of certain grapevine genes related to embryogenic competence, indicating a potential molecular response triggered by the inhibitor for enhancing embryogenic competence. This treatment also led to significant variations in the expression of histone deacetylase enzyme-encoding genes, offering possibilities for obtaining somatic embryos and reducing seasonal constraints in grapevine cultivation.
Article
Environmental Sciences
Zeynep Betts, Asuman Deveci Ozkan, Burcu Yuksel, Janiah Alimudin, Duygu Aydin, Ozlem Aksoy, Sevinc Yanar
Summary: The combination treatment of QUE and NaBu showed a significant synergistic inhibitory effect on hormone-sensitive breast cancer cells, suggesting it as a promising therapeutic approach for breast cancer treatment.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2023)
Article
Biochemistry & Molecular Biology
Xue Tang, Yongjuan Sun, Yingrui Li, Shuhua Ma, Kai Zhang, Ailing Chen, Yipin Lyu, Renqiang Yu
Summary: This study found differences in mitochondrial redox homeostasis and energy metabolism in tissues between obesity-prone and obesity-resistant rats. Sodium butyrate effectively promotes muscle protein synthesis, increases insulin sensitivity, and promotes glucose metabolism in obesity rats.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Oncology
Yang Xi, Zhuang Jing, Wu Wei, Zhang Chun, Qi Quan, Zhou Qing, Xu Jiamin, Han Shuwen
Summary: This study demonstrates that NaB inhibits proliferation, invasion, and metastasis of CRC cells by modulating complex molecular networks, indicating a potential therapeutic approach for CRC. The focus of further research should be on RNA prediction and molecular network construction.
Article
Multidisciplinary Sciences
Sean M. Callahan, Trevor J. Hancock, Ryan S. Doster, Caroline B. Parker, Mary E. Wakim, Jennifer A. Gaddy, Jeremiah G. Johnson
Summary: Histone modifications are involved in many processes in eukaryotes, including inflammation. Some bacterial pathogens use sirtuins to alter host histones and induce responses that promote infection. In this study, a Campylobacter jejuni deacetylase with sirtuin activities was found to contribute to activation of human neutrophils. This bacterial sirtuin is secreted into neutrophils, deacetylates host histones, and promotes neutrophil activation and extracellular trap production. The study also showed that this bacterial sirtuin is responsible for the inflammation and pathology observed during campylobacteriosis.
Article
Food Science & Technology
Huahuan Liu, Zhongbo Bian, Qiuyu Zhang, Zhipeng Xiao, Yu Cao, Xiaodie Sun, Yong Qin, Lianzhi Mao, Xinwei Chu, Wenzhen Liao, Longying Zha, Suxia Sun
Summary: Sodium butyrate (NaB) inhibits colorectal cancer by ameliorating gut microbiota dysbiosis and inhibiting colitis.
JOURNAL OF FUNCTIONAL FOODS
(2021)