期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 16, 期 19, 页码 8795-8800出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.09.016
关键词
modified nucleosides; methylation; synthesis of modified nucleosides; conformation of modified nucleosides; N-4,2'-O-dimethylcytidine
资金
- National Institutes of Health [AI061192, AI055496]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI055496, U01AI061192] Funding Source: NIH RePORTER
The dimethylated ribosomal nucleoside m(4)Cm and its monomethylated analogues Cm and m(4)C were synthesized. The conformations (syn vs anti) of the three modified nucleosides and cytidine were determined by CD and 1D NOE difference spectroscopy. The ribose sugar puckers were determined by the use of proton coupling constants. The position of modi. cation (e. g., O vs N methylation) was found to have an effect on the sugar pucker of cytidine. (C) 2008 Elsevier Ltd. All rights reserved.
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