Article
Biochemistry & Molecular Biology
Chensong Zhang, Yining Song, Guoqing Yan, Jiachi Ma
Summary: Fluorinated dual-crosslinked carboxymethyl chitosan (CMCS)-based nano-prodrugs with precise structure were developed to address the challenges of polysaccharide-based nano-prodrugs in clinical transformation. These nano-prodrugs showed metabolic stability, tumoral cellular uptake improvement, physicochemical stability at physiological pH, selective drug release and synergistic cytotoxicity at tumoral intracellular pH/GSH. They also exhibited stability in long-term storage and circulation, normal blood routine and aminotransferase, fantastic hemocompatibility, selective tumor accumulation and precise synergistic chemotherapy, achieving significant tumor growth inhibition while minimizing side effects.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Neurosciences
ShuJuan Fan, Li Li, LiRong Liu, He Li, XiaoHui Xian, WenBin Li
Summary: This study investigated the improving effect of ceftriaxone (Cef) on recognition memory deficits and the involvement of Group II mGluRs in the process using the APP/PS1 AD mouse model. The results showed that Cef treatment significantly improved the recognition memory deficits of the AD mice by suppressing the upregulation of Group II mGluRs expression and restoring the downregulation in the downstream molecules of Group II mGluRs activation.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Chemistry, Organic
Yuki Katayama, Kenta Watanabe, Yoshitake Nishiyama, Satoshi Yokoshima
Summary: We have developed a fluorinated 2,6-xylenesulfonyl group (fXs) as a protective group for amines. The sulfonyl group can be attached to amines using sulfonyl chlorides and can withstand various conditions, including acidic, basic, and reductive conditions. The fXs group can be cleaved by treatment with a thiolate under mild conditions.
Article
Biochemistry & Molecular Biology
Xiaoyang Qiu, Zeke Li, Yanggui Wu, Wolfgang H. Binder, Senbin Chen, Jintao Zhu
Summary: Chemodynamic therapy (CDT) combined with chemotherapy (CT) using core-coordinated amphiphilic polymer nanoparticles shows promising potential for enhancing antitumor outcomes. The self-assembled nanoparticles effectively deplete glutathione (GSH) through the reduction of Cu(II), resulting in the generation of center dot OH and promoting CDT. The release of chemotherapy drug chlorambucil (CBL) through disulfide bond cleavage contributes to further GSH decline, leading to a combined CDT/CT approach.
Review
Materials Science, Multidisciplinary
Jiang Wang, Yue Xing, Fang Wan, Can Fu, Chen-Hao Xu, Feng-Xia Liang, Lin-Bao Luo
Summary: Ultraviolet (UV) photodetectors (PDs) have wide applications and are crucial in modern optoelectronic devices and systems. II-VI group semiconductors are potential candidates for high-performance UVPD due to their wide bandgap and high exciton binding energy. This review comprehensively discusses the basic concepts and operation mechanisms of UVPDs and reviews the research status and techniques for enhancing performance of II-VI group semiconductor-based UVPDs.
JOURNAL OF MATERIALS CHEMISTRY C
(2022)
Review
Biochemistry & Molecular Biology
Shofiul Azam, Md. Jakaria, JoonSoo Kim, Jaeyong Ahn, In-Su Kim, Dong-Kug Choi
Summary: Metabotropic glutamate receptors (mGluRs), especially mGluR5, play important roles in neurodegenerative diseases and neuropsychiatric disorders. Recent research suggests that mGluR5 radioligands could be used to assess disease progression and track drug properties.
Article
Physiology
Chenlu Zhao, Chaohong Li, Baosheng Zhao, Yuzhen Liu
Summary: Acetylcholine is an important neurotransmitter that plays a crucial role in various physiological processes in the human body.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Chemistry, Medicinal
Yuanjiang Wang, Xinyi Wang, Gang Xu, Shaohua Gou
Summary: The CK2 inhibitor HY1 was found to effectively inhibit cancer stem cells in non-small cell lung cancer (NSCLC), and a Pt(II) agent (HY1-Pt) was developed to reverse cisplatin-induced drug resistance. HY1-Pt targets CK2, suppresses DNA damage repair, enhances cellular accumulation of platinum, and inhibits CSCs through the Wnt/beta-catenin signal pathway. In vivo studies show that HY1-Pt has promising pharmacokinetics and higher tumor growth inhibitory efficacy with lower toxicity compared to cisplatin.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Adrian Hernandez, Naveen Harindu Hemasiri, Samrana Kazim, Javier Ortiz, Shahzada Ahmad, Angela Sastre-Santos
Summary: Four symmetrically substituted and four asymmetrically substituted fluorinated and non-fluorinated-diarylamine CuPcs and ZnPcs were used as hole transporting materials in perovskite solar cells. The correlation between electronic structure, charge mobility parameters, core metal, and substituents in metal phthalocyanines was established. The best power conversion efficiency of 15.40% was achieved by the fluorinated asymmetrically substituted undoped ZnPc-6.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Review
Chemistry, Multidisciplinary
Soraya S. Santos, Rodrigo V. Gonzaga, Caue B. Scarim, Jeanine Giarolla, Marina C. Primi, Chung M. Chin, Elizabeth I. Ferreira
Summary: Hydroxymethylation is a simple chemical reaction that has various applications in drug research, including improving drug activity, increasing water solubility, and serving as an intermediary in synthesizing other therapeutic agents.
FRONTIERS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Hanna Kwon, Jaswir Basran, Chinar Pathak, Mahdi Hussain, Samuel L. Freeman, Alistair J. Fielding, Anna J. Bailey, Natalia Stefanou, Hazel A. Sparkes, Takehiko Tosha, Keitaro Yamashita, Kunio Hirata, Hironori Murakami, Go Ueno, Hideo Ago, Kensuke Tono, Masaki Yamamoto, Hitomi Sawai, Yoshitsugu Shiro, Hiroshi Sugimoto, Emma L. Raven, Peter C. E. Moody
Summary: Oxygen activation in heme enzymes requires the formation of high oxidation states of iron, known as ferryl heme, with two intermediates known as Compound I and Compound II. Recent crystal structure studies of Compound II in cytochrome c peroxidase and ascorbate peroxidase reveal differences in iron-oxygen bond lengths, suggesting fine-tuning of the ferryl species across closely related peroxidase enzymes.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biochemistry & Molecular Biology
Elzbieta Zmudzka, Klaudia Lustyk, Monika Gluch-Lutwin, Barbara Mordyl, Alicja Zakrzewska-Sito, Pawel Mierzejewski, Jolanta Jaskowska, Marcin Kolaczkowski, Jacek Sapa, Karolina Pytka
Summary: The study aimed to evaluate the antipsychotic-like effects of a novel compound, JJGW08, in rodents. The results showed that JJGW08 exhibited antagonistic properties at dopamine and serotonin receptors, and demonstrated anxiolytic and antipsychotic-like effects without inducing side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Alessandra Barbanente, Valentina Gandin, Chiara Donati, Carmela Ilaria Pierro, Giovanni Natile, Nicola Margiotta
Summary: Platinum-based drugs have been successful in treating solid tumors, but toxicity and resistance limit their outcomes. Natural products, such as 10-HDA found in royal jelly, are being explored as safe and easily available anti-cancer drugs. In this study, the researchers aimed to combine the functionality of 10-HDA with platinum to develop new compounds with potential anti-cancer activity. The synthesized compounds were characterized and tested for their cytotoxicity against human tumor cell lines. The results showed that some of the new compounds exhibited promising activity against specific tumor cell lines.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jianghua Fang, Xiaoyang Zhu, Wendi Luo, Jianxun Shi, Lejia Wang, Bin Tu, Qingdao Zeng, Xunwen Xiao
Summary: The self-assembly characteristics of tetrathiafulvalene derivatives at the interface were studied using scanning tunneling microscopy. The number of F atoms on the phenyl group was found to significantly affect the self-assembly structures.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Parikshit Moitra, Maha Alafeef, Ketan Dighe, Zach Sheffield, Dipendra Dahal, Dipanjan Pan
Summary: Tracking the viral progression of SARS-CoV-2 in COVID-19 infected body tissues is crucial, and NIR-II imaging technology shows promising benefits in exploring deep-tissue information. A molecular probe designed in this study selectively targets the N-gene of SARS-CoV-2 using specific antisense oligonucleotides conjugated to lead sulfide quantum dots. Ex vivo imaging studies demonstrated that the probe emits NIR-II only in the presence of SARS-CoV-2 RNA, indicating efficient hybridization of the ASOs with their target RNA strands.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Applied
Shunsuke Takahashi, Yuki Umakoshi, Kaii Nakayama, Yohei Okada, Viktor V. Zhdankin, Akira Yoshimura, Akio Saito
ADVANCED SYNTHESIS & CATALYSIS
(2020)
Review
Chemistry, Organic
Akio Saito
CURRENT ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Applied
Akira Yoshimura, Christopher D. Huss, Mackenzie Liebl, Gregory T. Rohde, Scott M. Larson, Gunnar B. Frahm, Mattew W. Luedtke, Tanner J. Schumacher, Zachary S. Gardner, Viktor V. Zhdankin, Pavel S. Postnikov, Mekhman S. Yusubov, Tsugio Kitamura, Akio Saito
Summary: Pseudocyclic beta-trifluorosulfonyloxy vinylbenziodoxolones were prepared and their structures were established by single crystal X-ray diffraction. The reaction of these compounds with azide anion led to beta-azido vinylbenziodoxolones, demonstrating vinylic nucleophilic substitution.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Organic
Sho Amemiya, Yui Takahashi, Akira Tsubouchi, Akio Saito
Summary: By controlling the conditions, 3-acylpyrrolidines can be synthesized and further subjected to a domino reaction to afford the desired product 4-alkylidene-3,4-dihydro-2H-pyrroles.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Michael T. Shea, Gregory T. Rohde, Yulia A. Vlasenko, Pavel S. Postnikov, Mekhman S. Yusubov, Viktor V. Zhdankin, Akio Saito, Akira Yoshimura
Summary: Hypervalent iodine heterocycles are an important class of reagents in organic synthesis, and this paper presents a simple and convenient method for the synthesis of benziodazolones using readily available iodobenzamides and m-chloroperoxybenzoic acid. The new iodine heterocycles were confirmed by X-ray analysis and shown to react more efficiently than analogous benziodoxolone reagents in esterification reactions.
Article
Chemistry, Applied
Yuki Umakoshi, Yusuke Takemoto, Akira Tsubouchi, Viktor V. Zhdankin, Akira Yoshimura, Akio Saito
Summary: A transition metal iodine catalyst is used to synthesize oxazoles through C-C bond formation between unfunctionalized alkynes and arenes, resulting in the introduction of aryl groups into the side chain of the compounds.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Irina A. Mironova, Valentine G. Nenajdenko, Pavel S. Postnikov, Akio Saito, Mekhman S. Yusubov, Akira Yoshimura
Summary: The intramolecular oxidative cycloaddition reaction of alkyne- or alkene-tethered aldoximes was efficiently catalyzed by hypervalent iodine(III) species, resulting in the formation of polycyclic isoxazole derivatives with yields of up to 94%. The structure of the products was confirmed through various methods, including X-ray crystallography. Mechanistic studies revealed the critical role of hydroxy(aryl)iodonium tosylate as a precatalyst, which is formed from 2-iodobenzoic acid and m-chloroperoxybenzoic acid in the presence of a catalytic amount of p-toluenesulfonic acid.
Article
Chemistry, Organic
Shun Sunagawa, Fumiya Morisaki, Takafumi Baba, Akira Tsubouchi, Akira Yoshimura, Kazunori Miyamoto, Masanobu Uchiyama, Akio Saito
Summary: In this study, the imidation of phosphines and a-amidation of 1,3-dicarbonyl compounds were achieved using N-triflylimino-lambda(3)-iodane, which was generated in situ from iodosylarene and triflylamide without any other additives. Additionally, the a-amidation of 1,3-dicarbonyl compounds was catalyzed by the imino-lambda(3)-iodane generated from an iodoarene precatalyst with oxone and triflylamide, representing the first method catalyzed by imino-lambda(3)-iodane.
Article
Chemistry, Organic
Daisuke Sato, Akira Tsubouchi, Yuichiro Watanabe, Keiichi Noguchi, Kazunori Miyamoto, Masanobu Uchiyama, Akio Saito
Summary: The activation of alkyne pi-bonds by transition metal complexes is well studied for the cycloisomerization of enynes into bicyclo[3.1.0]hexanes, enabling the introduction of carbon and oxygen functional groups. However, the cycloisomerization of enynones through the activation of carbonyl groups into bicyclo[3.1.0]hexanes has not yet been achieved. In this study, we report the aluminum halide-mediated cycloisomerization of 7-en-2-ynones into halogenated bicyclo[3.1.0]hexanes.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Review
Chemistry, Applied
Akira Yoshimura, Akio Saito, Viktor V. Zhdankin
Summary: Hypervalent iodine compounds, particularly those based on the benziodoxole heterocyclic system, are widely used as reagents and catalysts in modern organic chemistry. These cyclic hypervalent iodine reagents exhibit higher stability compared to their acyclic analogues, allowing for the safe handling and preparation of reagents with special ligands such as azido, cyano, and trifluoromethyl groups. They have been utilized for the transfer of substituents on hypervalent iodine to organic substrates under various reaction conditions. This review focuses on the recent synthetic applications of cyclic hypervalent iodine(III) reagents with different ligands, including N-3, NHR, CN, CF3, SCF3, OR, OAc, ONO2, and C(=N-2)CO2R, mainly in the past 5 years.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Organic
Sae Tsubata, Akira Tsubouchi, Akio Saito
Summary: Recently, a metal-free cyclization-allylation reaction of o-alkynylanilines catalyzed by iodine(i) species has been developed, providing a new approach for green and sustainable chemistry. The method involves carbo-deiodination of iodocyclized intermediates and rearrangement of allyl groups, resembling the mechanism of transition metal-catalysis. This represents the first iodine-catalysis via carbo-deiodination with the rearrangement of functional groups.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Organic
Yuki Umakoshi, Kazushige Wakisaka, Akira Tsubouchi, Akira Yoshimura, Akio Saito
Summary: This article reports a new method for the construction of a cyclic skeleton concomitant with the introduction of a functional group through a tandem reaction. This method does not require prefunctionalization of the coupling partner, making it greener.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Organic
Akio Saito
Summary: This article mainly introduces two approaches to the metal-free and single-step synthesis of heterocycles via an activation of alkynes by iodine (III). One method involves the iodine (III)-mediated/catalyzed oxidative cycloisomerization reactions of propargyl compounds, while the other method includes iodine (III)-mediated/catalyzed oxidative annulation of alkynes and nitriles.
JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN
(2021)
Article
Chemistry, Multidisciplinary
Akira Yoshimura, Christopher D. Huss, Akio Saito, Tsugio Kitamura, Viktor V. Zhdankin
Summary: The presence of trifluoromethanesulfonic anhydride enhances the efficiency of 2-Iodosylbenzoic acid as an oxidant and electrophilic reagent for the preparation of alkenyl and aryliodonium salts, offering compatibility with acid-sensitive functional groups and mild reaction conditions resulting in higher yields.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Organic
Sho Amemiya, Shingo Okemoto, Akira Tsubouchi, Akio Saito
Summary: A synthetic method for alpha-(aminoethyl)-alpha,beta-enones from aryl-substituted homopropargyl sulfonamides and aldehydes was developed, representing the first synthesis of conjugated enones via alkyne aza-Prins cyclization. These products could be further converted into pyrrolidines.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
