期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 16, 期 14, 页码 6747-6751出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2008.05.059
关键词
antidiabetic agents; flavone; 2,4-thiazolidinediones; flavonyl-2,4-thiazolidinediones; insulinotropic activity; aldose reductase inhibition; synthesis
A new series of flavonyl-2,4-thiazolidinediones (Va-c, VIa-c) was prepared by Knoevenagel reaction. The synthesized compounds were tested for their ability to inhibit rat kidney aldose reductase (AR) and for their insulinotropic activities in INS-1 cells. Compound Vb was able to increase insulin release in the presence of 5.6 mmol/l glucose. Compounds VIa-c displayed moderate to high AR inhibitory activity levels. Particularly, compound VIa showed the highest AR inhibitory activity (86.57%). (c) 2008 Elsevier Ltd. All rights reserved.
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