Review
Biochemistry & Molecular Biology
Laura L. Kiessling, Roger C. Diehl
Summary: The text discusses how proteins recognize sugars through CH-π interactions, highlighting the importance of electron-rich aromatic residues in glycan binding.
ACS CHEMICAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Daisuke Asai, Naoko Inoue, Makiko Sugiyama, Tsugumi Fujita, Yutaka Matsuyama, Xiaohui Liu, Ayami Matsushima, Takeru Nose, Tommaso Costa, Yasuyuki Shimohigashi
Summary: This study verifies the importance of the position of benzene hydrogen atoms in activating the receptor, finding that benzene-hydrogen atoms at the ortho and meta positions, rather than the para position, play a crucial role in CH/pi interaction.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Lirong Yu, Mengxing Zhang, Dandan Lou, Jiale Li, Xi Wang, Ming Bai
Summary: In this study, a novel strategy was used to investigate the aggregation mode of a TPE derivative, revealing a well-ordered molecular packing in the aggregated state. The unique self-assembly behavior driven by CH/pi-interaction and solvophobicity in the DMSO/H2O mixture was observed. This discovery sheds light on the theoretical research and design of TPE-based luminogens.
Article
Chemistry, Organic
Joanna Hager, Seongsoo Kang, Piotr J. Chmielewski, Tadeusz Lis, Dongho Kim, Marcin Stepien
Summary: In this study, a series of pi-extended dibenzoullazines containing an acenaphthylene subunit were successfully synthesized using two different synthetic strategies. These compounds exhibit strong fluorescence and moderate solvatochromism, making them potentially useful in various applications. Additionally, a chiral ullazine analogue with axial chirality was discovered and successfully resolved into enantiomers.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Inorganic & Nuclear
Shun Li, Guo-Ling Li, Wei Wang, Yang Liu, Zhong-Min Cao, Xue-li Cao, You-Gui Huang
Summary: A new compound with an interesting twofold 2D + 2D -> 3D hetero-interpenetrating framework was successfully synthesized at room temperature. The framework is built from a 2D metal–organic framework and a 2D supramolecular framework assembled by CH/pi interactions, which interact with each other by strong pi center dot center dot center dot pi stacking and CH/pi interactions.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Polymer Science
Jin Gu, Xiaohua Wang, Wenpeng Zhao, Rui Zhuang, Chunyu Zhang, Xuequan Zhang, Yinghui Cai, Wenbo Yuan, Bo Luan, Bo Dong, Heng Liu
Summary: This study disclosed a family of half-titanocene complexes with pi,pi-stacked aryloxide ligands and their catalytic performances towards ethylene homo-/co- polymerizations. It was found that these complexes could highly catalyze ethylene polymerizations and copolymerizations, and the strength of pi,pi-stacking interaction was influenced by the size of the aryloxide's 7 pi-system. Additionally, the catalytic efficiency could be significantly enhanced by the addition of external pyrene molecules.
Article
Biochemistry & Molecular Biology
Amin O. Elzupir, Rageh K. Hussein, Khalid H. Ibnaouf
Summary: This study demonstrates the presence of CH-pi interaction in PFO-1 due to aggregate formation in the liquid state. The absence of aggregate formation in PFO-2 is attributed to the steric hindrance caused by branched alkyl side chains. Density Functional Theory calculations confirm the higher ability of PFO-1 to form CH-pi bonds.
Article
Nanoscience & Nanotechnology
Jiaqi Zhou, Shaokui Jia, Xiaorui Xue, Xintai Hao, Qingrui Zeng, Xing Wang, Xueguang Ren
Summary: The inner-valence ionization and fragmentation dynamics of CH4-C6H6 dimer induced by 200 eV electron impact are studied using multi-particle coincidence momentum spectroscopy. The three-dimensional momentum vectors and kinetic energy release (KER) of the CH4 (+)+C6H6 (+) ion pairs are measured through coincident momentum measurement. The analysis on the absolute cross sections reveals that the intermediate dication CH4 (+)-C6H6 (+) is preferentially formed by the removal of an inner-valence electron and subsequent relaxation, followed by two-body Coulomb explosion. Real-time fragmentation dynamics including translational, vibrational and rotational motions are presented based on ab initio molecular dynamics (AIMD) simulations. The revealed fragmentation dynamics have potential implications for crystal structure imaging with different radiation sources.
Article
Pharmacology & Pharmacy
Lingling Qi, Chao Liu, Yingying Zhang, Zheao Zhang, Hongxia Duan, Heming Zhao, Xin Xin, Liqing Chen, Mingji Jin, Youyan Guan, Zhonggao Gao, Wei Huang
Summary: Micelle is commonly used for drug delivery, but faces challenges with encapsulating water-soluble drugs and maintaining stability. Fmoc-Lys-PEG and Fmoc-Lys-PEG-RGD copolymers were designed to address these issues, successfully encapsulating a water-soluble drug using hydrogen bonding. The nanoparticles showed high anti-tumor activity both in vitro and in vivo.
Article
Pharmacology & Pharmacy
Maria C. Llorens de los Rios, Priscila A. Lanza, Cecilia L. Barbieri, Maria L. Gonzalez, Macarena Funes Chaban, Gaston Soria, D. Mariano A. Vera, Maria C. Carpinella, Mariana B. Joray
Summary: This study explores flora from Argentina as a source of new chemical entities with antiangiogenic activity. It identifies α-terthienylmethanol in T. minuta as a promising antiangiogenic phytochemical with potential implications in fighting against various types of cancer.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Mohan Tiwari, C. N. Ramachandran
Summary: Auro-acetylene clusters form stable cyclic structures through C-Au···π interactions.
CHEMICAL PHYSICS LETTERS
(2022)
Article
Physics, Atomic, Molecular & Chemical
Shiqian Tan, Yizhen Wang, Igor Ying Zhang, Xin Xu
Summary: Accurate description of potential energy curves driven by non-bonded interactions remains a challenge for pure density functional approximations (DFAs). Empirical dispersion correction is commonly used to treat non-bonded interactions. However, the revXYG3 and XYG7 functionals, which are doubly hybrid approximations, show promise in providing a balanced description of non-bonded interactions for various prototype interactions.
CHINESE JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Biochemical Research Methods
Vanthana Jeyasingh, Kumaresan Murugesan, Sudha Lakshminarayanan, Narayanan Selvapalam, Geetha Das, Lakshminarayanan Piramuthu
Summary: In this study, a pyrene based probe associated with pi center-dot-hydrazone as one of the recognizing elements is synthesized and transformed into a selective colorimetric and turn-on fluorescent sensor (L-3) for cyanide anion. The chemo sensor exhibits high selectivity towards cyanide anion through a photo electron transfer (PET) mechanism, with a binding strength and sensitivity of 2.0 X 10(4) and 4.44 x 10(-4) respectively. Comparison with previously reported receptors L-1 and L-2 shows the homogeneous dispersion of pi center-dot-hole in the aromatic ring governing the selectivity of the receptor towards cyanide anion.
JOURNAL OF FLUORESCENCE
(2021)
Article
Chemistry, Multidisciplinary
Prasanta Kumar Bhaumik, Rosa M. Gomila, Antonio Frontera, Samia Benmansour, Carlos J. Gomez-Garcia, Shouvik Chattopadhyay
Summary: The hooked cross-shaped anion participates in strong CH center dot center dot center dot[Cu(N-3)(4)](2-) interactions in the pentanuclear hetero-metallic copper(II)-sodium complex. DFT calculations, MEP analysis, and NCI plot index analysis were used to analyze and characterize these interactions. Cation-pi interactions between the pentacoordinated Na-atom and the aromatic ring of the Schiff base ligand were described and compared with existing X-ray structures.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Emma-Lucille Blayney, Milna Chennath, Charles G. Cranfield, Ronald J. Clarke
Summary: The Na+, K+-ATPase is an integral membrane protein that uses ATP hydrolysis to transport Na+ and K+ ions across the plasma membrane. It has essential roles in various physiological processes and is regulated through phosphorylation by protein kinase C (PKC) and Src kinase families. The study used the mirror tree method to analyze the coevolution between these kinases and Na+, K+-ATPase. The results suggested that the theta and eta isoforms of PKC and Src kinase are the most likely to interact with Na+, K+-ATPase. These findings will guide future experimental studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Siyuan Yao, Shintaro Yagi, Masaaki Hirata, Yosuke Miyachi, Eri Ogawa, Ryuji Uozumi, Takuya Sugimoto, Takashi Asahara, Shinji Uemoto, Etsuro Hatano
Summary: This prospective study investigated the changes in gut microbiota and associated intestinal environment during the early period after liver transplantation. The recipients showed dysbiosis and depletion of organic acid before transplantation, which were related to the severity of liver disease. The transplantation procedure caused minimal changes in gut microbiota and organic acid concentrations in the donors, while the recipients exhibited delayed recovery in these factors.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Letter
Chemistry, Organic
Sogen Okuda, Chihiro Tsukano, Kazuhiro Irie
Summary: A set of four stereoisomeric compounds were designed and synthesized as ligands of protein kinase C (PKC). The compounds were simplified analogs of the alotaketals, a class of natural products that were predicted to be ligands of PKC by computational screening. Bioassays revealed that the orientation of the alkyl side chain of the analogs was important for PKC binding and that the stereochemistry of the fused ring moiety influenced the PKC isozyme selectivity.
Article
Chemistry, Multidisciplinary
Hidetaka Kuroiwa, Soichiro Suzuki, Kazuhiro Irie, Chihiro Tsukano
Summary: Lancilactone C is a tricyclic triterpenoid that can inhibit the replication of human immunodeficiency virus (HIV) in H9 lymphocytes without cytotoxicity. It has a tricyclic skeleton consisting of trans-dimethyl-bicyclo[4.3.0]nonane and 7-isopropylene-cyclohepta-1,3,5-triene. The latter structure, in which all carbon atoms are sp (2) hybridized, is unique and needs to be synthetically verified.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Shun Sato, Kana Yamamoto, Moeno Ito, Katsutoshi Nishino, Takanao Otsuka, Kazuhiro Irie, Masaya Nagao
Summary: Two types of cathepsin K inhibitors were identified in the methanol extract of Chamaecrista nomame. One type can inhibit both cathepsin K and B, while the other type only inhibits cathepsin K, suggesting allosteric binding. The combination of these inhibitors with other allosteric inhibitors enhances their inhibitory activity, providing important insights for designing new allosteric inhibitory drugs.
Article
Biochemistry & Molecular Biology
Yusuke Hanaki, Yuki Shikata, Masayuki Kikumori, Mutsumi Okamura, Shingo Dan, Masaya Imoto, Kazuhiro Irie
Summary: A compound called 10-methyl-aplog-1 has been found to inhibit the proliferation of specific cancer cell lines without side effects. It achieves this by inhibiting PKCa and inducing PP2A-mediated attenuation of the Akt/S6 signaling axis, leading to G1 arrest in cancer cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Takeo Koshida, Tomohito Gohda, Takuya Sugimoto, Takashi Asahara, Rin Asao, Isao Ohsawa, Hiromichi Gotoh, Maki Murakoshi, Yusuke Suzuki, Yuichiro Yamashiro
Summary: The composition of the gut microbiome differs between patients with chronic kidney disease (CKD) undergoing hemodialysis (HD) and those with normal renal function (NRF). This difference is associated with altered levels of stool organic acids, systemic inflammation, and accumulation of uremic toxins (UTs). Furthermore, the levels of UTs, inflammatory markers, and stool organic acids differ significantly between patients with NRF and those undergoing HD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Takuya Sugimoto, Satomi Atobe, Yukiko Kado, Akira Takahashi, Masaaki Motoori, Keijiro Sugimura, Hiroshi Miyata, Masahiko Yano, Koji Tanaka, Yuichiro Doki, Osamu Shiraishi, Takushi Yasuda, Takashi Asahara
Summary: The study aims to identify the gut microbiota involved in adverse events during neoadjuvant chemotherapy (NAC) and that affect the efficacy of LBG therapy. The results show that higher abundance of Anaerostipes hadrus and Bifidobacterium pseudocatenulatum is associated with lower incidence of febrile neutropenia and severe diarrhoea. Furthermore, LBG+EN therapy is positively correlated with intestinal concentrations of acetic acid and butyric acid.
JOURNAL OF MEDICAL MICROBIOLOGY
(2023)
Article
Chemistry, Organic
Hideyuki Komatsu, Takahide Shigeyama, Takuya Sugimoto, Hiroyuki Nishiyama
Summary: The Doebner hydrogen-transfer reaction has been developed for synthesizing substituted quinolines from anilines with electron-withdrawing groups. This reaction overcomes the low yield problem encountered in the conventional Doebner reaction. It can be applied to anilines with both electron-withdrawing and electron-donating groups, making it suitable for large-scale synthesis of bioactive molecules.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Hideyuki Komatsu, Takahide Shigeyama, Takuya Sugimoto, Hiroyuki Nishiyama
Summary: The Doebner hydrogen-transfer reaction has been developed as a method for synthesizing substituted quinolines from anilines with electron-withdrawing groups, which typically yield low product yields in conventional Doebner reactions. This reaction can be applied to anilines with both electron-withdrawing and electron-donating groups, making it useful for large-scale synthesis of bioactive molecules.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Takahito Maki, Masahito Sawahata, Daisuke Uta, Kazuhiro Irie, Toshiaki Kume
Summary: Chronic treatment with E22P-A beta 42 and LPS was found to increase nitric oxide production and interleukin-6 (IL-6) expression, while reducing the expression of HIF-1 alpha and HIF-3 alpha in BV-2 microglia. Furthermore, it was observed that E22P-A beta 42 and LPS enhanced nuclear translocation of nuclear factor-kappaB (NF-.B). These findings suggest that E22P-A beta 42 may enhance the inflammatory response of microglia through abnormal HIF signaling, contributing to the progression of Alzheimer's disease pathology.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Review
Chemistry, Organic
Chihiro Tsukano, Ayumi Uchino, Kazuhiro Irie
Summary: This review presents the strategies for synthesizing symmetric amino acid derivatives and describes their applications in life sciences.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jumpei Maki, Yusuke Hanaki, Ryo C. Yanagita, Masayuki Kikumori, Anastasiia Kovba, Ayaka Washizaki, Chihiro Tsukano, Hirofumi Akari, Kazuhiro Irie
Summary: The phosphate ester of 10-methyl-aplog-1, known as phos-10MA-1, shows similar biological activity with 10MA-1 in vitro and has the potential to reactivate latent HIV for HIV eradication strategy.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Kazuma Murakami, Yoshiki Sakaguchi, Kota Taniwa, Naotaka Izuo, Mizuho Hanaki, Taiji Kawase, Kenji Hirose, Takahiko Shimizu, Kazuhiro Irie
Summary: Preventing the aggregation of amyloid beta (A beta) is important for preventing Alzheimer's disease (AD). In this study, a green perilla-derived chalcone (DDC) was found to inhibit A beta aggregation. The active structures in metastable dietary compounds can interact with the aggregation sites of A beta and inhibit its aggregation.
RSC CHEMICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yoshiyuki Suzuki, Keiichi Moritoki, Mizuki Kajiwara, Ryo C. Yanagita, Yasuhiro Kawanami, Yusuke Hanaki, Kazuhiro Irie
Summary: A simplified analog of aplysiatoxin (ATX) was synthesized with fewer steps and exhibited comparable antiproliferative activity to the reference compound. Carvone may be a potential candidate for a more synthetically accessible drug.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Jumpei Maki, Asami Oshimura, Chihiro Tsukano, Ryo C. Yanagita, Yutaka Saito, Yasubumi Sakakibara, Kazuhiro Irie
Summary: Protein kinase C (PKC) family is a potential target for treating cancer, Alzheimer's disease, and HIV infection. By screening compounds and designing analogues, we discovered a PKC ligand with remarkable isozyme selectivity.
CHEMICAL COMMUNICATIONS
(2022)