Article
Biochemistry & Molecular Biology
Andrea Magnavacca, Stefano Piazza, Anna Cammisa, Marco Fumagalli, Giulia Martinelli, Flavio Giavarini, Enrico Sangiovanni, Mario Dell'Agli
Summary: The study found that blackcurrant leaf extract has a better effect on interfering with IFN-gamma signaling compared to TNF-alpha or IL-4. This suggests that RNLE may have an anti-allergic effect in keratinocytes through mechanisms beyond histamine involvement.
Article
Toxicology
Lo-Wei Lin, Blythe P. Durbin-Johnson, David M. Rocke, Michelle Salemi, Brett S. Phinney, Robert H. Rice
Summary: This study focuses on the effects of environmental pro-oxidants on the formation and protein composition of epidermal cornified envelopes (CEs). The results show that pro-oxidants can alter the CE proteome and that the cellular redox state plays an important role in CE formation.
TOXICOLOGICAL SCIENCES
(2023)
Article
Dermatology
Yanghe Liu, Chen Zhang, Bing Li, Chen Yu, Xiaocui Bai, Chunying Xiao, Lei Wang, Erle Dang, Luting Yang, Gang Wang
Summary: IL-17A inhibits the suppressive function of Tregs by blocking TGF-beta release and promoting IFN-gamma production. Treatment with anti-IL-17A in psoriasis patients restores the suppressive function of Tregs.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Food Science & Technology
Jung Eun Park, Hee Jun Kwon, Hwa Jin Lee, Hyung Seo Hwang
Summary: Taxifolin, a bioactive flavonoid, exhibits antioxidant, anticancer, and anti-inflammatory properties. It has been shown to improve psoriasis in animal experimental models. This study investigated the molecular and cellular mechanism of taxifolin's anti-inflammatory effect on psoriasis using HaCaT human keratinocytes. Results indicated that taxifolin had no cytotoxicity and significantly inhibited the expression of pro-inflammatory cytokines and chemokines. This inhibition was correlated with the phosphorylation of I kappa B/STAT3 protein. Moreover, taxifolin also inhibited the expression of inflammatory cytokines upon stimulation of various factors. These findings suggest that taxifolin holds promise as a potential treatment for psoriasis and skin inflammation.
APPLIED BIOLOGICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Benjamin Ehst, Zhiping Wang, Justin Leitenberger, Danielle McClanahan, Rachel De La Torre, Erika Sawka, Alex G. Ortega-Loayza, Jennifer Strunck, Teri Greiling, Eric Simpson, Yuangang Liu
Summary: IL-23 plays a crucial role in Th17 immunity and inflammatory responses, especially in diseases like psoriasis. While dendritic cells are considered the main source of IL-23 in psoriasis, there is controversy surrounding the expression of IL-23 in psoriatic keratinocytes. Research has shown that a combination of TNF alpha and IL-17A can induce IL-23 production in human keratinocytes, with enhanced effects in psoriatic keratinocytes and EGFR signaling.
Article
Parasitology
Fernanda Ferreira Evangelista, Leticia Nishi, Cristiane Maria Colli, Priscila de Laet Sant'Ana, Lourenco T. Higa, Luiz Henrique Garcia Muniz, Ana Lucia Falavigna-Guilherme
Summary: This study compared the levels of cytokines in the amniotic fluid and serum of pregnant women with acute toxoplasmosis. It found that IL-17A was significantly higher in the acute phase of infection, suggesting a potential protective factor against fetal infection. The absence of T. gondii DNA in the amniotic fluid indicates a limited transmission risk to the fetus.
Article
Plant Sciences
Zhenzhuo Li, Rui Jiang, Chenxu Jing, Jianzeng Liu, Xiaohao Xu, Liwei Sun, Daqing Zhao
Summary: The study found that the ginseng oligosaccharide extract can effectively repair UVB-induced skin barrier damage, alleviate skin dryness, and desquamation symptoms.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Vusala Abbasova, Ahmet Gul, Guher Saruhan-Direskeneli
Summary: Gamma delta T cells and CD4(+) T cells have complementary roles in cytokine production in Behcet's disease. The higher IFN-gamma production of gamma delta T cells suggests the role of environmental triggers in Behcet's disease pathogenesis, while IL-17 related activity is mainly provided by CD4(+) T cells.
IMMUNOLOGY LETTERS
(2022)
Article
Immunology
Wenjuan Yang, Rukun He, Hao Qu, Wenwen Lian, Yue Xue, Tao Wang, Wenlong Lin, Peishuo Zhu, Meng Xia, Lihua Lai, Qingqing Wang
Summary: FXYD3 is upregulated in the lesional skin of psoriasis patients and mice with IMQ-induced psoriasis. It promotes IL-17A signaling in keratinocytes, leading to inflammation and the expression of proinflammatory factors, exacerbating psoriasis. Targeting FXYD3 could be a potential therapeutic approach for psoriasis.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Dermatology
Pawit Phadungsaksawasdi, Toshiharu Fujiyama, Kazuo Kurihara, Taisuke Ito, Tetsuya Honda, Yoshiki Tokura
Summary: In human psoriasis, PD-1 expressing CD8(+) CD103(+) T cells in the skin are associated with disease severity and histopathology, indicating a potential pathogenic subset that may play a role in psoriasis pathogenesis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Cell Biology
Di Xu, Jie Wang
Summary: The study revealed that cathepsin B expression is elevated in IL-17A and SAA-induced HaCaT keratinocytes, and silencing it can reduce cell proliferation and inflammatory response while promoting cell differentiation.
Article
Cell Biology
Kaho Hayashi, Sae Nozaki, Kanako Tokushima, Fumika Tanaka, Yohei Hirai
Summary: The skin epidermis has a complex structure with layers of keratinocytes, and outer layer keratinocytes form physical barriers called cornified cell envelope (CCE) and tight junctions (TJs). In this study, it was found that the t-SNARE protein syntaxin3 is crucial for organizing the physical barriers in poorly polarized keratinocytes. Cells lacking syntaxin3 displayed increased susceptibility to cell death and loss of TJ and CCE structures.
CELL AND TISSUE RESEARCH
(2023)
Article
Plant Sciences
Zhenzhuo Li, Rui Jiang, Manying Wang, Lu Zhai, Jianzeng Liu, Xiaohao Xu, Liwei Sun, Daqing Zhao
Summary: This study reveals the potential of ginsenosides (GS) in preventing skin photoaging by protecting the skin barrier. The researchers identified the main monomeric constituents of GS and found that GS protects the skin barrier by inhibiting the MAPK signaling pathway, as shown in experiments on hairless mice and HaCaT cells.
JOURNAL OF GINSENG RESEARCH
(2022)
Article
Immunology
Yan Yin, Shengrong Ouyang, Qin Li, Yuyang Du, Shiqiu Xiong, Min Zhang, Wei Wang, Ting Zhang, Chuanhe Liu, Ying Gao
Summary: This study found that the levels of IL-17A and IFN-gamma in the saliva of children with food allergies were higher than those in healthy children. This finding provides a basis for diagnosing food allergies and measuring the effectiveness of treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Baojiang Chen, Chen Li, Guizhen Chang, Huan Wang
Summary: This study found that DHA can inhibit the excessive proliferation and inflammation of skin cells in patients with psoriasis by targeting FGFR1, providing a new target for the treatment of psoriasis.
Article
Chemistry, Medicinal
Jinha Yu, Long Xuan Zhao, Jongmi Park, Hyuk Woo Lee, Pramod K. Sahu, Minghua Cui, Steven M. Moss, Eva Hammes, Eugene Warnick, Zhan-Guo Gao, Minsoo Noh, Sun Choi, Hee-Chul Ahn, Jungwon Choi, Kenneth A. Jacobson, Lak Shin Jeong
JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Article
Dermatology
Moonyoung Lee, Eunyoung Lee, Sun Hee Jin, Sungjin Ahn, Sae On Kim, Jungmin Kim, Dalwoong Choi, Kyung-Min Lim, Seung-Taek Lee, Minsoo Noh
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Sungjin Ahn, Moonyoung Lee, Seungchan An, Sooyeol Hyun, Jiho Hwang, Jongkook Lee, Minsoo Noh
BIOORGANIC & MEDICINAL CHEMISTRY
(2018)
Article
Toxicology
Sungjin Ahn, Seungchan An, Moonyoung Lee, Eunyoung Lee, Jeong Joo Pyo, Jeong Hyeon Kim, Min Won Ki, Sun Hee Jin, Jaehyoun Ha, Minsoo Noh
ARCHIVES OF TOXICOLOGY
(2019)
Article
Chemistry, Medicinal
Sungjin Ahn, Basavana M. K. Gowda, Moonyoung Lee, Jagadeesh Nagarajappa Masagalli, Karabasappa Mailar, Won Jun Choi, Minsoo Noh
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Pharmacology & Pharmacy
Eunyoung Lee, Sungjin Ahn, Sun Hee Jin, Moonyoung Lee, Jeong Joo Pyo, Jeayoung C. Shin, Seungchan An, Jaehyoun Ha, Minsoo Noh
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Hyunkyung Cho, Joo-Youn Lee, Sang Yoon Choi, Chaemin Lim, Min-Kyoung Park, Hyejin An, Jeong Ok Lee, Minsoo Noh, Seunghee Lee, Sanghee Kim
Article
Chemistry, Organic
Oh-Seok Kwon, Sungjin Ahn, Ju-eun Jeon, In Guk Park, Tae Hyung Won, Chung J. Sim, Hyeung-geun Park, Dong-Chan Oh, Ki-Bong Oh, Minsoo Noh, Jongheon Shin
Summary: Psammocindoles A-C, a new class of indole alkaloids isolated from a Psammocinia vermis sponge, were found to significantly stimulate adiponectin secretion in human bone marrow mesenchymal stem cells.
Article
Plant Sciences
Changyeol Lee, Junpyo Gong, Jaekyeong Kim, Hyejin Ko, Seungchan An, Sunghee Bang, Stephen T. Deyrup, Minsoo Noh, Sang Hee Shim
Summary: New hybrid compounds and polyketides with potential therapeutic effects on metabolic diseases were isolated from ahalophyte-associated fungus. One of the compounds displayed a similar biological activity to aspirin.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Medicinal
Mai Nguyen, Seungchan An, Yen Nguyen, Young Eum Hyun, Hongseok Choi, Linh Pham, Jung-Ae Kim, Minsoo Noh, Gyudong Kim, Lak Shin Jeong
Summary: In this study, L-nucleoside analogues were synthesized using computer-aided design and were found to exhibit enhanced adiponectin-secretion-promoting activity and improved PPAR binding activities compared to n-nucleoside analogues.
ACS MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Medicinal
Seungchan An, Seok Young Hwang, Junpyo Gong, Sungjin Ahn, In Guk Park, Soyeon Oh, Young-Won Chin, Minsoo Noh
Summary: In this study, a machine-learning model was developed to predict the adiponectin-secretion-promoting activity of flavonoid-associated phytochemicals (FAPs). By establishing a structure-activity relationship model and a multiple linear regression model, the adiponectin activity of FAPs was successfully predicted and validated through experimental validation, providing a computational reconstruction method for phenotype-based screening systems.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Plant Sciences
Jaekyeong Kim, Hyejin Ko, Jae-Seoun Hur, Seungchan An, Jin Woo Lee, Stephen T. Deyrup, Minsoo Noh, Sang Hee Shim
Summary: Compounds from an extract of an endolichenic fungus have the potential to promote adiponectin synthesis, making them promising candidates for treating metabolic diseases such as obesity and diabetes.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Plant Sciences
Young-Won Chin, Piseth Nhoek, Sungjin Ahn, Pisey Pel, Young-Mi Kim, Jungmoo Huh, Hyun Woo Kim, Minsoo Noh
Summary: Five new quinoline alkaloids (1, 2, 4, 8, and 9) and three new coumarins (15, 17, and 19), along with 20 known compounds, were identified from a methanol extract of Orixa japonica leaves. The structures were determined using NMR spectroscopic data analysis. Compound 19's absolute configuration was proposed using electronic circular dichroism calculation. Compound 4 and 12 were found to stimulate adiponectin secretion in human bone marrow mesenchymal stem cells, with EC50 values of 13.8 and 25.8 mu M, respectively. Compound 4 and 12 were also identified as selective PPARy agonists based on PPARy binding assay and molecular modeling.
JOURNAL OF NATURAL PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Moonju Choi, Minkyung Park, Suhyon Lee, Jeong Woo Lee, Min Chul Cho, Minsoo Noh, Choongho Lee
BIOMOLECULES & THERAPEUTICS
(2017)
Article
Dermatology
Hyangmi Kim, Minsoo Noh, Ok-Nam Bae, Chang-Hoon Lee, Ai-Young Lee
ACTA DERMATO-VENEREOLOGICA
(2017)