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Neurosciences
Yonghai Wang, Hongchun Li, Ying Zhao, Feng Qin, Liang Wang, Linhong Jiang, Xiaojie Wang, Rong Chen, Yuman He, Qinfan Wei, Shu Li, Yuanyuan Chen, Yuzhou Xiao, Yanping Dai, Qian Bu, Yinglan Zhao, Jingwei Tian, Hongbo Wang, Xiaobo Cen
Summary: Sevoflurane exposure in the neonatal period causes cognitive impairment and social behavior deficits in adolescent rats. Lipidomics and proteomics analysis revealed the remodeling of lipid metabolism and downregulation of LPCAT1 expression in the hippocampus, suggesting their involvement in neurobehavioral dysfunction.
Article
Fisheries
Yi Ding, Kun Cui, Shangzhe Han, Tingting Hao, Yongtao Liu, Wencong Lai, Xiang Xu, Kangsen Mai, Qinghui Ai
Summary: This study reveals the role of fish LPCAT3 in inflammation induced by palmitate and suggests that targeting SREBP1 might be an effective coping strategy.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Thibaut Bourgeois, Antoine Jalil, Charles Thomas, Charlene Magnani, Naig Le Guern, Thomas Gautier, Jean-Paul Pais de Barros, Victoria Bergas, Helene Choubley, Loic Mazzeo, Louise Menegaut, Lorene Josiane Lebrun, Kevin Van Dongen, Marion Xolin, Tony Jourdan, Chloe Buch, Jerome Labbe, Philippe Saas, Laurent Lagrost, David Masson, Jacques Grober
Summary: Recent studies have found that LPCAT3 plays an important role in controlling the PUFA composition of cell membranes in the liver and intestine, but its role in macrophages remains controversial. Partial LPCAT3 deficiency in macrophages alters the PUFA composition of phospholipid subclasses and reduces cholesterol efflux, but does not impact inflammatory response or ER stress. Ultimately, myeloid LPCAT3 deficiency may affect AA homeostasis in the liver, leading to metabolic disorders and triglyceride accumulation.
JOURNAL OF LIPID RESEARCH
(2021)
Article
Food Science & Technology
Yaozhong Hu, Jiaxin Gu, Jing Lin, Yi Wang, Feier Yang, Jia Yin, Zhenting Yu, Sihao Wu, Huan Lv, Xuemeng Ji, Shuo Wang
Summary: The intervention of EGCG on macrophage polarization was found to promote M2 polarization and inhibit M1 polarization, particularly in liver, colon, spleen, and brain.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Rui Sun, Jia Le Lin, Man Si Cheng, Kang Yi Lee, Thilo Spruss, Christa Buechler, Herbert Schwarz
Summary: This study investigated the role of chemerin in rhabdomyosarcoma (RMS), finding a high expression rate of chemerin in RMS cases and revealing that the absence of chemerin can increase the expression of inhibitory molecules and cytokines, supporting tumor progression in the tumor microenvironment.
Article
Immunology
Fabiola Gonzalez-Herrera, Natasha S. Clayton, Daniela Guzman-Rivera, Ileana Carrillo, Christian Castillo, Mabel Catalan, Renatto Anfossi, Helena Quintero-Pertuz, Maria Elena Quilaqueo, Claudio Olea-Azar, Mario Rivera-Meza, Ulrike Kemmerling, Anne J. Ridley, Raul Vivar, Juan Diego Maya
Summary: This study demonstrates that statins can inhibit ROCK activity, reduce inflammation, and promote anti-inflammatory cytokine expression, suggesting that statins may be a potential pharmacological strategy for preventing cardiac inflammation in CCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiachun Hu, Yan Deng, Tingbo Ding, Jibin Dong, Yuning Liang, Bin Lou
Summary: Phosphatidylcholines (PCs) are major phospholipids in the mammalian cell membrane. Lpcat3, an acyltransferase, plays a crucial role in maintaining plasma membrane fluidity by incorporating polyunsaturated fatty acyl chains into PCs. Our study reveals that increased expression of Lpcat3 is associated with adipose tissue overexpansion and dysfunction.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Cell Biology
Chen Chen, Jianan Ma, Chenchen Pi, Wei Huang, Tao Zhang, Cong Fu, Wentao Liu, Yong-Guang Yang
Summary: IL-10(+) regulatory B cells (Bregs) are important in cancer immunotherapy with PPAR delta playing a significant role in their development and function. In this study, PPAR delta was found to be upregulated in tumor-induced IL-10(+) Bregs, and its expression level was correlated with IL-10 production and T cell inhibition. Genetic inactivation of PPAR delta impaired IL-10(+) Breg development and function, while treatment with a PPAR delta inhibitor reduced their induction. Immunotherapy with CD40 or PD1 antibodies had improved outcomes in tumor-bearing mice with PPAR delta deficiency or treated with a PPAR delta inhibitor.
Review
Biochemistry & Molecular Biology
Hailong Zhao, Mingdong Huang, Longguang Jiang
Summary: The article reviews the role of CHI3L1 in various diseases, emphasizing its relationship with macrophages. In addition, it introduces various mechanisms and therapeutic approaches to inhibit CHI3L1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ken Woo, So Young Park, Andrew Padalhin, Hyun Seok Ryu, Celine DG. Abueva
Summary: This study investigated the effect of photobiomodulation (PBM) treatment on tonsil-derived mesenchymal stem cells (TMSCs) and its interaction with RAW 264.7 macrophage cells. The results showed that PBM priming improved the therapeutic efficacy of TMSCs and supported M2 macrophage polarization. Based on these findings, PBM can enhance the therapeutic efficacy of TMSCs for potential applications in oral mucositis and wound healing.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Qingfeng Wu, Shiren Sun, Lei Wei, Minna Liu, Hao Liu, Ting Liu, Ying Zhou, Qing Jia, Di Wang, Zhen Yang, Menglu Duan, Xiaoxia Yang, Peisong Gao, Xiaoxuan Ning
Summary: This study reveals a significant association between Twist1 expression in macrophages and the severity of renal fibrosis in IgA nephropathy patients and mice with unilateral ureteral obstruction. Twist1 ablation in macrophages alleviates renal tubular injury and fibrosis, accompanied by reduced macrophage infiltration and M2 polarization in the kidney. Twist1 downregulation inhibits macrophage chemotaxis and migration, at least partially through the CCL2/CCR2 axis. This study highlights the regulation of macrophage plasticity through Twist1/galectin-3 signaling and its potential as a new strategy for delaying kidney fibrosis in chronic kidney disease patients.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Sree Samanvitha Kuppa, Hyung Keun Kim, Ju Yeon Kang, Seok Cheol Lee, Jong Keun Seon
Summary: Osteoarthritis is a low-grade inflammatory disorder of the joints, but there are limited treatment options currently available. This article explores the use of mesenchymal stem cells and their secreted factors for intervention in osteoarthritis, with a focus on the polarization of macrophages to reduce inflammation and symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Renata F. Saito, Maria Cristina Rangel, Justin R. Halman, Morgan Chandler, Luciana Nogueira de Sousa Andrade, Silvina Odete-Bustos, Tatiane Katsue Furuya, Alexis German Murillo Carrasco, Adriano B. Chaves-Filho, Marcos Y. Yoshinaga, Sayuri Miyamoto, Kirill A. Afonin, Roger Chammas
Summary: The study found that simultaneously silencing all four LPCAT transcripts using nucleic acid nanoparticles (NANPs) enhanced the therapeutic effects of radiation in melanoma cells by increasing cell death, reducing long-term cell survival, and activating apoptosis, suggesting that NANPs are an effective strategy for improving radiotherapy efficacy in melanomas.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2021)
Article
Immunology
Yanli Ma, Yu Chen, Hong Xu, Ni Du
Summary: This study found that the knockout of Angptl3 can alleviate podocyte damage and macrophage polarization in diabetic nephropathy mice, as well as regulate the podocyte epithelial-mesenchymal transition (EMT) process. Furthermore, it was discovered that the knockout of Angptl3 can improve podocyte inflammation and NLRP3 inflammasome activation in diabetic nephropathy by affecting macrophage polarization.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Naga Lakshmi Challa, Ankita Sarkar, Satyamoorthy Kapettu, Prakash Babu Phanithi, Partha Chakrabarti, Kishore V. L. Parsa, Parimal Misra
Summary: Macrophage-driven chronic low-grade inflammatory response is closely associated with insulin resistance and type 2 diabetes. The TGS1 gene plays a role in regulating macrophage activation and polarization, and affects the development of insulin resistance in skeletal muscle cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
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Dentistry, Oral Surgery & Medicine
K. H. Yeom, W. Ariyoshi, T. Okinaga, A. Washio, T. Morotomi, C. Kitamura, T. Nishihara
INTERNATIONAL ENDODONTIC JOURNAL
(2016)
Article
Chemistry, Analytical
Satoshi Fujii, Shinobu Sato, Keisuke Fukuda, Toshinori Okinaga, Wataru Ariyoshi, Michihiko Usui, Keisuke Nakashima, Tatsuji Nishihara, Shigeori Takenaka
ANALYTICAL SCIENCES
(2016)
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Biochemistry & Molecular Biology
Shirou Tabe, Hisako Hikiji, Wataru Ariyoshi, Tomomi Hashidate-Yoshida, Hideo Shindou, Toshinori Okinaga, Takao Shimizu, Kazuhiro Tominaga, Tatsuji Nishihara
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Orthopedics
Junya Furuta, Wataru Ariyoshi, Toshinori Okinaga, Jun Takeuchi, Sho Mitsugi, Kazuhiro Tominaga, Tatsuji Nishihara
JOURNAL OF ORTHOPAEDIC RESEARCH
(2017)
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Biochemistry & Molecular Biology
Mai Otsuka, Toshinori Okinaga, Wataru Ariyoshi, Chiaki Kitamura, Tatsuji Nishihara
JOURNAL OF CELLULAR BIOCHEMISTRY
(2017)
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Biochemistry & Molecular Biology
Tomonari Kajita, Wataru Ariyoshi, Toshinori Okinaga, Sho Mitsugi, Kazuhiro Tominaga, Tatsuji Nishihara
JOURNAL OF CELLULAR BIOCHEMISTRY
(2018)
Article
Agriculture, Dairy & Animal Science
N. Jaffar, T. Okinaga, T. Nishihara, T. Maeda
JOURNAL OF DAIRY SCIENCE
(2018)
Article
Dentistry, Oral Surgery & Medicine
Y. Moritani, M. Usui, K. Sano, K. Nakazawa, T. Hanatani, M. Nakatomi, T. Iwata, T. Sato, W. Ariyoshi, T. Nishihara, K. Nakashima
JOURNAL OF PERIODONTAL RESEARCH
(2018)
Article
Cell Biology
Junya Kaneko, Toshinori Okinaga, Wataru Ariyoshi, Hisako Hikiji, Seiko Fujii, Kenjiro Iwanaga, Kazuhiro Tominaga, Tatsuji Nishihara
CELL BIOLOGY INTERNATIONAL
(2018)
Article
Cell Biology
Wichida Chaweewannakorn, Wataru Ariyoshi, Toshinori Okinaga, Yuko Fujita, Kenshi Maki, Tatsuji Nishihara
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Multidisciplinary Sciences
Fumika Hirabayashi, Kenjiro Iwanaga, Toshinori Okinaga, Osamu Takahashi, Wataru Ariyoshi, Ryo Suzuki, Mutsumi Sugii, Kazuo Maruyama, Kazuhiro Tominaga, Tatsuji Nishihara
Article
Multidisciplinary Sciences
Shirou Tabe, Hisako Hikiji, Wataru Ariyoshi, Tomomi Hashidate-Yoshida, Hideo Shindou, Takao Shimizu, Toshinori Okinaga, Yuji Seta, Kazuhiro Tominaga, Tatsuji Nishihara
SCIENTIFIC REPORTS
(2017)
Correction
Anesthesiology
Sakiko Kitamura, Kenichi Takechi, Tasuku Nishihara, Amane Konishi, Yasushi Takasaki, Toshihiro Yorozuya
JOURNAL OF CLINICAL ANESTHESIA
(2019)
Article
Immunology
Junya Kaneko, Toshinori Okinaga, Hisako Hikiji, Wataru Ariyoshi, Daigo Yoshiga, Manabu Habu, Kazuhiro Tominaga, Tatsuji Nishihara
INFLAMMATION AND REGENERATION
(2018)
Article
Biochemistry & Molecular Biology
Wichida Chaweewannakorn, Wataru Ariyoshi, Toshinori Okinaga, Kazumasa Morikawa, Katsura Saeki, Kenshi Maki, Tatsuji Nishihara
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)