期刊
BIOMICROFLUIDICS
卷 8, 期 1, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.4862355
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资金
- NSF [CBET-0853873, DMS-1319078]
- National Research Foundation of Korea [2011-0014246]
Shape is an intrinsic marker of cell cycle, an important factor for identifying a bioparticle, and also a useful indicator of cell state for disease diagnostics. Therefore, shape can be a specific marker in label-free particle and cell separation for various chemical and biological applications. We demonstrate in this work a continuous-flow electrical sorting of spherical and peanut-shaped particles of similar volumes in an asymmetric double-spiral microchannel. It exploits curvature-induced dielectrophoresis to focus particles to a tight stream in the first spiral without any sheath flow and subsequently displace them to shape-dependent flow paths in the second spiral without any external force. We also develop a numerical model to simulate and understand this shape-based particle sorting in spiral microchannels. The predicted particle trajectories agree qualitatively with the experimental observation. (C) 2014 AIP Publishing LLC.
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