Review
Chemistry, Multidisciplinary
Samaneh Zare Harofte, Madjid Soltani, Saeed Siavashy, Kaamran Raahemifar
Summary: Nowadays, artificial intelligence creates numerous opportunities in the life sciences. Integrating AI with microfluidics can significantly impact various fields of biotechnology.
Article
Biochemistry & Molecular Biology
Elise Delannoy, Geraldine Tellier, Juliette Cholet, Alice M. Leroy, Anthony Treizebre, Fabrice Soncin
Summary: Blood vessel-on-a-chip models have been developed to replicate vascular functions. In this study, a viscous finger patterning technique was used to create blood vessels-on-chips with various internal diameters inside a collagen solution. The blood vessels were composed of two concentric layers of human endothelial and perivascular cells and showed a tight vascular barrier. The presence of perivascular cells increased the tightness of the barrier and reduced its response to thrombin. This design allowed for high-throughput drug screening.
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Article
Chemistry, Physical
Cristina Chircov, Alexandra Catalina Birca, Alexandru Mihai Grumezescu, Bogdan Stefan Vasile, Ovidiu Oprea, Adrian Ionut Nicoara, Chih-Hui Yang, Keng-Shiang Huang, Ecaterina Andronescu
Summary: The study introduced a new method for the synthesis of magnetite nanoparticles using a microfluidic lab-on-chip device to achieve controlled properties. It investigated the influence of iron precursor solution concentration and flow on the final properties of the nanomaterials, ultimately achieving uniformity and stability in the synthesized nanoparticles.
Review
Chemistry, Analytical
Ruth Shinar, Joseph Shinar
Summary: Organic electronics (OE) technology has matured in displays and is advancing in solid-state lighting applications. It also shows great potential in (bio)chemical sensing, imaging, in vitro cell monitoring, and other biomedical diagnostics. OE devices, such as organic LEDs, organic and hybrid perovskite-based photodetectors, and organic thin-film transistors, are utilized in these applications. The integration of compact and sensitive OE devices with microfluidic channels and lab-on-a-chip (LOC) structures is very promising.
Article
Biochemical Research Methods
Tianjin Yang, Karin J. Buholzer, Andrea Sottini, Xiaobao Cao, Andrew Demello, Daniel Nettels, Benjamin Schuler
Summary: Probing non-equilibrium dynamics with single-molecule spectroscopy is important for understanding biomolecular mechanisms. Existing microfluidic mixing systems are not suitable for surface-adhesive biomolecules, but droplet-based microfluidic mixing overcomes these limitations.
Article
Chemistry, Analytical
Daphika S. Dkhar, Rohini Kumari, Shweta J. Malode, Nagaraj P. Shetti, Pranjal Chandra
Summary: Lab-on-a-chip (LOC) biosensors have attracted research interest for their potential in personal healthcare and disease diagnostics. This review discusses various fabrication methods and techniques for designing LOC sensing devices, as well as the types of transduction systems that play a crucial role in sensing. The detection of analytes, including small molecules, macromolecules, and cells, is comprehensively reviewed with illustrations and tables.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Rosalia Moreddu, Vahid Nasrollahi, Panagiotis Kassanos, Stefan Dimov, Daniele Vigolo, Ali K. Yetisen
Summary: In this article, femtosecond laser writing is used to engrave microfluidic networks into commercial contact lenses, achieving rapid and precise processing. The ablation process and tear flow within microfluidic structures are evaluated experimentally and computationally. Functional microfluidic components such as flow valves, resistors, and two applications, a tear volume sensor and a tear uric acid sensor, are introduced, providing painless alternatives with reduced contamination risks.
Article
Biochemistry & Molecular Biology
Emanuele Piccinno, Anna Grazia Monteduro, Francesco Dituri, Silvia Rizzato, Gianluigi Giannelli, Giuseppe Maruccio
Summary: The study validated a miniaturized on-chip platform for real-time, non-destructive cell proliferation assays and drug screening, comparing its effectiveness with the traditional 96-well plate assay. Results showed the new platform's efficacy comparable to the standard method, with advantages in reagent consumption, operator time, and costs, potentially accelerating drug development processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Multidisciplinary
Dorina T. Papanastasiou, Abderrahime Sekkat, Viet Huong Nguyen, Carmen Jimenez, David Munoz-Rojas, Franz Bruckert, Daniel Bellet
Summary: This paper introduces a transparent heater based on silver nanowire networks, protected with a transparent zinc oxide film, for temperature control in biological experiments under transparent microscopic observation. The experimental results demonstrate that the nanocomposites allow rapid and reproducible heating under low applied voltage, and achieve selective heating in different zones of microchannels or adjacent microchannels at different temperatures.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Review
Biotechnology & Applied Microbiology
Hongyong Zhang, Guoguang Rong, Sumin Bian, Mohamad Sawan
Summary: With the increasing population, neurological disorders have become a growing concern. However, there is still a lack of effective therapies. Understanding the neuronal network (NoN) in the human brain is essential for understanding the pathology of neurological diseases. Recent advances in nanomaterials and micro-/nano-microfabrication have opened up new possibilities for ex vivo NoN studies. This review summarizes the latest advances in lab-on-chip microsystems for ex vivo NoN studies, focusing on advanced materials, techniques, and models.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Ecology
Ryan Wimbles, Louise M. Melling, Bradley Cain, Naomi Davies, Jason Doherty, Bridget Johnson, Kirsty J. Shaw
Summary: This study developed a microfluidic device for genetic analysis of White Rhinoceros dung samples, providing a portable and cost-effective solution for species identification to aid conservation efforts. Optimization of DNA extraction processes and the use of specific amplification reactions allowed for accurate detection results to be obtained quickly.
ECOLOGY AND EVOLUTION
(2021)
Review
Chemistry, Multidisciplinary
Adithya Sridhar, Ashish Kapoor, Ponnusamy Senthil Kumar, Muthamilselvi Ponnuchamy, Balasubramanian Sivasamy, Dai-Viet Nguyen Vo
Summary: The advancement of microfluidic systems has revolutionized lab-on-a-chip devices, showing great potential in the food industry. Research focuses on fabrication technologies, materials, pathogen detection methods, and smart packaging technologies for better product identification and traceability.
ENVIRONMENTAL CHEMISTRY LETTERS
(2022)
Article
Environmental Sciences
Matt Mowlem, Alexander Beaton, Robin Pascal, Allison Schaap, Socratis Loucaides, Sam Monk, Andrew Morris, Christopher L. Cardwell, Sara E. Fowell, Matthew D. Patey, Patricia Lopez-Garcia
Summary: A new product line utilizing in situ lab on chip technology has been introduced for high accuracy measurements of water chemistry parameters, even in deep sea environments. Commercially available sensors include Nitrate, Nitrite, Phosphate, Silicate, Iron, and pH sensors. The technology is adaptable for a wide range of environmental measurements, particularly for chemical and biological parameters that require reagents.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Engineering, Electrical & Electronic
Samith Hettiarachchi, Gehan Melroy, Amith Mudugamuwa, Peshan Sampath, Charith Premachandra, Ranjith Amarasinghe, Van Dau
Summary: This paper discusses the modeling, simulation, and experimentation of an active droplet generator used in LOC devices, focusing on the key factor of droplet generation. The study found that optimized droplet contraction width and flow rate ratios are crucial for effective droplet generation. Experimental results show that droplet formation occurs within a certain range of flow rate ratios, with droplet diameter decreasing as the flow rate ratio decreases.
SENSORS AND ACTUATORS A-PHYSICAL
(2021)