Biosensors for immune cell analysis-A perspective

Massively parallel analysis of single immune cells or small immune cell colonies for disease detection, drug screening, and antibody production represents a killer app for the rapidly maturing microfabrication and microfluidic technologies. In our view, microfabricated solid-phase and flow cytometry platforms of the future will be complete with biosensors and electrical/mechanical/optical actuators and will enable multi-parametric analysis of cell function, real-time detection of secreted signals, and facile retrieval of cells deemed interesting. (C) 2012 American Institute of Physics. [http://dx.doi.org/10.1063/1.4706845]