Article
Biochemistry & Molecular Biology
Kayleigh Griffiths, Tomoaki Ida, Masanobu Morita, Reece J. Lamb, Jordan J. Lee, Michael P. Frenneaux, Jon M. Fukuto, Takaaki Akaike, Martin Feelisch, Melanie Madhani
Summary: Earlier studies have shown that CysSSH, a sulfur-containing compound, has antioxidant and oxidant properties and can mitigate oxidative stress. However, its role in myocardial IRI was not understood. This study investigated the production and consumption of CysSSH in the heart under normoxic and hypoxic conditions and found that exogenous administration of Cys-SSS-Cys can rescue the heart from injury and improve cardiac function.
Article
Medicine, Research & Experimental
Minghua Wen, Feng Hu, Zhijian Gong, Chahua Huang, Xiaoshu Cheng
Summary: This study investigated the protective effect of blood plasma extracellular particles (EPs) released during remote ischemic preconditioning (RIPC) on oxidative stress injury in human umbilical vein endothelial cells (HUVECs). The results showed that RIPC-EPs could improve cell viability and reduce cytotoxicity, cell apoptosis, and necrosis. HIF-1α may mediate this protective effect.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Yongliang Hua, Yanan Xu, Xinglong Li, Bing Yin, Shounan Lu, Chaoqun Wang, Shanjia Ke, Baolin Qian, Hongjun Yu, Miaoyu Bai, Yong Ma
Summary: The aim of this study was to investigate the protective mechanisms of ischaemic preconditioning (IPC) against ischaemia-reperfusion (I/R) injury and explore the role of long non-coding RNAs (lncRNAs). The results showed that IPC improved liver damage by reducing liver transaminase levels and pro-inflammatory cytokines. Gene ontology and pathway analyses revealed that the differentially expressed genes (DEGs) were mainly associated with protein folding and metabolism. Additionally, several DEGs were validated using the lncRNA-mRNA weighted coexpression network.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Hiran A. Prag, Anja Gruszczyk, Margaret M. Huang, Timothy E. Beach, Timothy Young, Laura Tronci, Efterpi Nikitopoulou, John F. Mulvey, Raimondo Ascione, Anna Hadjihambi, Michael J. Shattock, Luc Pellerin, Kourosh Saeb-Parsy, Christian Frezza, Andrew M. James, Thomas Krieg, Michael P. Murphy, Dunja Aksentijevic
Summary: Release of accumulated succinate in the ischaemic heart upon reperfusion is mediated by MCT1 and is facilitated by acidification of the myocardium during ischaemia.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cell Biology
Lei-Lei Ma, Fei-Juan Kong, Zheng Dong, Kai-Yue Xin, Xing-Xu Wang, Ai-Jun Sun, Yun-Zeng Zou, Jun-Bo Ge
Summary: Transient non-ischaemic hypertrophy stimulation through TAC preconditioning can render the heart resistant to subsequent ischaemic injury, reducing myocardial infarct size and apoptosis, and improving cardiac function significantly. TAC preconditioning attenuates I/R-induced autophagy by deacetylating SOD2 via a SIRT3-dependent mechanism, highlighting a novel strategy for cardioprotection against cardiac injury.
CELL PROLIFERATION
(2021)
Article
Multidisciplinary Sciences
Daniel Brandhorst, Heide Brandhorst, Samuel Acreman, Paul R. Johnson
Summary: Islet cells, especially from NHBD, showed greater benefits from hypoxic preconditioning (HP), including increased cell yields, viability, and in vitro function, and decreased apoptosis and reactive oxygen species generation. HP also decreased pro-apoptotic gene expression and increased HIF-1 and VEGF expression.
SCIENTIFIC REPORTS
(2022)
Review
Respiratory System
Dimitrios Vlastos, Mohamed Zeinah, George Ninkovic-Hall, Stefanos Vlachos, Agni Salem, Athanasios Asonitis, Hemangi Chavan, Lazaros Kalampalikis, Abdullah Al Shammari, Jose Maria Alvarez Gallesio, Aina Pons, Ioanna Andreadou, Ignatios Ikonomidis
Summary: This article provides a narrative review of the existing experimental and clinical evidence regarding the effects of ischemic conditioning on lung ischemia-reperfusion injury (LIRI) and prompts further investigation to refine its clinical application.
RESPIRATORY RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Nabil Sayour, Gabor B. Brenner, Andras Makkos, Bernadett Kiss, Csenger Kovacshazi, Tamas G. Gergely, Sverre Groever Aukrust, Huimin Tian, Viktoria Zenkl, Kamilla Gomori, Tamara Szabados, Peter Bencsik, Andre Heinen, Rainer Schulz, Gary F. Baxter, Coert J. Zuurbier, Zoltan Voko, Peter Ferdinandy, Zoltan Giricz
Summary: In this study, RIPC was found to have no cardioprotective effect in rats, based on randomized and blinded in vivo studies in three study centres using different RIPC protocols. However, a systematic review and meta-analysis of in vivo rat models showed that RIPC could reduce infarct size by an average of 21.28%. These results highlight the need for more well-designed and well-reported studies to confirm these findings and develop clinically translatable cardioprotective interventions.
CARDIOVASCULAR RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Lei-Lei Ma, Zhi-Wen Ding, Pei-Pei Yin, Jian Wu, Kai Hu, Ai-Jun Sun, Yun-Zeng Zou, Jun-Bo Ge
Summary: The study shows that preconditioning with hypertrophic stress protects the heart from I/R injury by improving mitochondrial metabolism, reducing oxidative/nitrative stress and inhibiting apoptosis. ALDH2 is obligatorily required for the development of cardiac hypertrophic preconditioning and acts as the mediator of this process.
Article
Cardiac & Cardiovascular Systems
R. M. Bell, M. Basalay, H. E. Botker, S. Beikoghli Kalkhoran, R. D. Carr, J. Cunningham, S. M. Davidson, T. J. England, S. Giesz, A. K. Ghosh, P. Golforoush, A. V. Gourine, D. J. Hausenloy, G. Heusch, B. Ibanez, P. Kleinbongard, S. Lecour, K. Lukhna, M. Ntsekhe, M. Ntsekhe, M. Ovize, A. D. Salama, G. Vilahur, J. M. Walker, D. M. Yellon
Summary: The Hatter Cardiovascular Institute biennial workshop focused on the future of Remote Ischaemic Conditioning (RIC), discussing the mechanisms of conditioning, the disconnect between preclinical and clinical studies, and the potential applications of RIC in other diseases. The workshop proposed specific classifications to identify responders and non-responders.
BASIC RESEARCH IN CARDIOLOGY
(2022)
Article
Cell Biology
Liqun Jia, Ling Yang, Yikui Tian, Lieming Yang, Dawei Wu, Hao Zhang, Mingbiao Li, Naishi Wu
Summary: This research focused on the effect of Nrf2 in the treatment of myocardial ischaemia-reperfusion injury (MIRI) through mitochondrial transplantation. The study found that exogenous mitochondria can be internalized into cardiomyocytes and activate the Nrf2 pathway, leading to improved cardiac function and alleviated mitochondrial dysfunction.
CELLULAR SIGNALLING
(2022)
Article
Cell Biology
Shaoqin Li, Yi Zhou, Xiaocheng Gu, Xiaoping Zhang, Zhongzhi Jia
Summary: NLRX1 plays a key role in regulating mitophagy in intestinal ischaemic reperfusion (IR) injury, potentially serving as a therapeutic target for the condition. The activation of the NLRX1-FUNDC1-NIPSNAP1/NIPSNAP2 axis contributes to mitochondrial homeostasis and cell apoptosis, highlighting its significance in mitigating intestinal IR injury.
CELL PROLIFERATION
(2021)
Article
Urology & Nephrology
Alexis Piedrafita, Stephane Balayssac, Nicolas Mayeur, Stephane Gazut, Julia Grossac, Marie Buleon, Melinda Alves, Julie Klein, Vincent Minville, Bertrand Marcheix, Joost P. Schanstra, Stanislas Faguer
Summary: The study found a significant decrease in tryptophan and kynurenin in AKI patients, but NAM supplementation did not have a significant effect on improving kidney outcomes.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Biotechnology & Applied Microbiology
Xingjian Zhang, Peng Du, Kaifeng Luo, Yong Li, Zhongzhong Liu, Wei Wang, Cheng Zeng, Qifa Ye, Qi Xiao
Summary: This study revealed that HIF-1 alpha could protect against hepatic ischemia-reperfusion injury by upregulating the A2BAR signaling pathway, reducing hepatocyte apoptosis and inflammatory response, and alleviating oxidative stress.
Review
Neurosciences
James A. Lang, Jahyun Kim
Summary: Remote ischaemic preconditioning (RIPC), induced by intermittent periods of limb ischaemia and reperfusion, confers cardiac and vascular protection from subsequent ischaemia-reperfusion (IR) injury. However, translating these adaptations to clinical practice in humans has been challenging. Factors such as age, fitness, frequency, disease state and interactions with medications may affect the efficacy of RIPC in humans. Human experimental models may be necessary to better understand the underlying mechanisms and to determine the clinical potential of RIPC.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Biochemistry & Molecular Biology
Xiangyu Zou, Yanping Hou, Jinxia Xu, Liang Zhong, Jin Zhou, Guangyuan Zhang, Jie Sun
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Endocrinology & Metabolism
Ying Fan, Zhengzi Yi, Vivette D. D'Agati, Zeguo Sun, Fang Zhong, Weijia Zhang, Jiejun Wen, Ting Zhou, Ze Li, Li He, Qunzi Zhang, Kyung Lee, John Cijiang He, Niansong Wang
Article
Medicine, Research & Experimental
Jianyong Yin, Xuanchen Liu, Ting Zhao, Rulian Liang, Rui Wu, Fangfei Zhang, Yiwei Kong, Limei Liu, Tao Xing, Niansong Wang, Qing Zhao, Feng Wang
Article
Urology & Nephrology
Feng Wang, Jianyong Yin, Yingying Lin, Fangfei Zhang, Xuanchen Liu, Guangyuan Zhang, Yiwei Kong, Zeyuan Lu, Rui Wu, Niansong Wang, Tao Xing, Youcun Qian
KIDNEY INTERNATIONAL
(2020)
Article
Biochemistry & Molecular Biology
Qunzi Zhang, Li He, Yang Dong, Yang Fei, Jiejun Wen, Xiaomei Li, Jian Guan, Feng Liu, Ting Zhou, Ze Li, Ying Fan, Niansong Wang
Article
Oncology
Siwei Qian, Si Sun, Lei Zhang, Shengwei Tian, Kai Xu, Guangyuan Zhang, Ming Chen
FRONTIERS IN ONCOLOGY
(2020)
Article
Cell Biology
Xiaomei Li, Jiejun Wen, Yang Dong, Qunzi Zhang, Jian Guan, Feng Liu, Ting Zhou, Ze Li, Ying Fan, Niansong Wang
Summary: Immune and inflammatory factors are key pathophysiological mechanisms in diabetic renal injury, with noncanonical Wnt5a signaling playing a crucial role. Upregulation of Wnt5a and CD146 in DN patients is correlated with inflammation and renal impairment progression. Inhibition of Wnt5a signaling prevents inflammatory responses induced by high glucose, and CD146 plays an essential role in activating the Wnt5a pathway.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Guangyuan Zhang, Lei Zhang, Si Sun, Ming Chen
Summary: This study identified CANX, BID, NAMPT, and BIRC5 as immune-autophagy-related genes with independent prognostic value in kidney renal clear cell carcinoma. These genes were significantly correlated with immune score, immune checkpoint, iron death, methylation, and OCLR score. The risk prognostic model based on them was well constructed, and experimental results were consistent with the bioinformatics analysis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Si Sun, Weipu Mao, Lilin Wan, Kehao Pan, Liting Deng, Lei Zhang, Guangyuan Zhang, Ming Chen
Summary: This study found that FGF17, PRKCG, SSTR1, and SCTR were metastatic immune-related differentially expressed genes (mIR-DEGs) with independent prognostic values in renal clear cell carcinoma. These genes were significantly associated with clinicopathological factors and immune checkpoint-related genes. The risk prognostic model based on these genes showed good predictive potential.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Surgery
Si Sun, Weipu Mao, Shuchun Tao, Lilin Wan, Xiangyu Zou, Guangyuan Zhang, Ming Chen
Summary: The aim of this study was to assess the effect of preoperative blood glucose levels on the length of stay in patients with kidney stones undergoing percutaneous nephrolithotomy. The results demonstrated that higher preoperative blood glucose levels were significantly associated with longer length of stay in these patients.
FRONTIERS IN SURGERY
(2022)
Article
Surgery
Weipu Mao, Shuqiu Chen, Lijie Zhang, Tao Li, Si Sun, Bin Xu, Weidong Zhu, Guangyuan Zhang, Lei Zhang, Jianping Wu, Ming Chen
Summary: This study presents the functional outcomes and postoperative complications of modified Y-shaped ileal orthotopic neobladder reconstruction. The surgery is shown to be simple, safe, and clinically applicable.
FRONTIERS IN SURGERY
(2022)
Article
Urology & Nephrology
Guangyuan Zhang, Lei Zhang, Sun Si, Tiancheng Jiang, Yi Xia, Yongkun Zhu, Xiangyu Zhang, Chi Yao, Ming Chen, Shuqiu Chen
Summary: Low fibrinogen is an independent predictor of in-hospital mortality in critically ill patients with AKI. Low ATIII activity is also likely to impact the risk of in-hospital death.
Article
Cell Biology
Chi Yao, Guangyuan Zhang, Nieke Zhang, Renjie Li, Si Sun, Lei Zhang, Yi Xia, Shuqiu Chen, Jin Sun, Ming Chen
Summary: This study found that fibrinogen levels are associated with the prognosis of sepsis patients. The relationship between elevated and decreased levels of fibrinogen and mortality was shown to be nonlinear. Subgroup analysis confirmed the robustness of this association. However, after adjusting for confounding factors, the association between decreased fibrinogen levels and increased inhospital mortality was denied.
MEDIATORS OF INFLAMMATION
(2023)
Article
Biology
Wei Zhu, Chengjie Wu, Zhen Zhou, Guangyuan Zhang, Lianmin Luo, Yang Liu, Zhicong Huang, Guoyao Ai, Zhijian Zhao, Wen Zhong, Yongda Liu, Guohua Zeng
Summary: Acetate treatment can improve renal injury and fibrosis in hyperoxaluria by inhibiting macrophage infiltration through the promotion of miR-493-3p expression and suppression of macrophage migration inhibitory factor expression.
COMMUNICATIONS BIOLOGY
(2023)
Article
Cell Biology
Guang-Yuan Zhang, Yan-Wei Wang, Li-Ying Guo, Liang-Ru Lin, Shao-Peng Niu, Chang-Hao Xiong, Jing-Yan Wei
Summary: In this study, a hGPx1 mutant (GPx1M) with high activity was prepared using a single protein production (SPP) system. The GPx1M was conjugated with SS-mPEG to enhance its stability, and it showed good antioxidant effects both in vitro and in vivo.