Article
Public, Environmental & Occupational Health
Joshua Kuan Tan, Gek Hsiang Lim, Nur Nasyitah Mohamed Salim, Sing Yi Chia, Julian Thumboo, Yong Mong Bee
Summary: The study investigates the association between mean HbA1c, HbA1c variability, and all-cause mortality and diabetes-related macrovascular complications in patients with diabetes. The results show that both low (<6%) and high (>=8%) levels of HbA1c are associated with increased risk of all-cause mortality and diabetes-related macrovascular complications. Patients with stable HbA1c levels of 6-8% have the lowest risk.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Medicine, General & Internal
Archana Sharma, Ingrid Nermoen, Elisabeth Qvigstad, Anh T. Tran, Christine Sommer, Naveed Sattar, Jason M. R. Gill, Hanne L. Gulseth, Stina T. Sollid, Kare Birkeland
Summary: This study revealed significant ethnic differences in actionable ADA-HbA(1c) levels between South Asian and Nordic women with previous GDM, with important risk factors including South Asian ethnicity, GDM history, use of glucose-lowering drugs during pregnancy, older age, and higher fasting glucose levels during pregnancy.
Review
Medicine, General & Internal
Sudipta Sarker Mou, Clare Gillies, Jiamiao Hu, Marianna Danielli, Bassel Hamameeh Al Wattar, Kamlesh Khunti, Bee Kang Tan
Summary: Gestational diabetes mellitus (GDM) is a common metabolic disorder in pregnancy, and it is associated with maternal and fetal complications. The HbA1c level at 24-28 weeks of pregnancy may predict the development of fetal macrosomia or large for gestational age (LGA) in women with GDM. A systematic review and meta-analysis showed that women with high HbA1c values had a higher risk of giving birth to an LGA baby. Further research is needed to evaluate the utility of HbA1c levels in predicting the delivery of a baby with fetal macrosomia or LGA in pregnant women.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
S. Pillay, D. Pillay, R. Pillay
Summary: The majority of patients with diabetes mellitus visiting public healthcare facilities in KZN have suboptimal glycemic control, highlighting the need to increase awareness of HbA1c testing and provide point-of-care testing services.
SAMJ SOUTH AFRICAN MEDICAL JOURNAL
(2021)
Review
Endocrinology & Metabolism
Magdalena Beran, Rutendo Muzambi, Anouk Geraets, Juan Rafael Albertorio-Diaz, Marcel C. Adriaanse, Marjolein M. Iversen, Andrzej Kokoszka, Giesje Nefs, Arie Nouwen, Frans Pouwer, Jorg W. Huber, Andreas Schmitt, Miranda T. Schram
Summary: The study found a bidirectional longitudinal association between depressive symptoms and HbA(1c), with small effect sizes observed. Future research in large-scale longitudinal studies is needed to confirm this association. Future studies should investigate the role of diabetes type, depression, diabetes distress, and diabetes self-management behaviors.
Article
Endocrinology & Metabolism
Adam H. Dyer, Robert Briggs, Eamon Laird, Leane Hoey, Catherine F. Hughes, Helene McNulty, Mary Ward, J. J. Strain, Anne M. Molloy, Conal Cunningham, Kevin McCarroll
Summary: In older adults, both high HbA(1c) levels and the presence of diabetes are associated with poorer cognitive performance and specific domain-specific neuropsychological performance. This suggests that focusing on HbA(1c) levels, not just diabetes status, may be important for promoting optimal brain health in older adults.
Article
Biophysics
Mukesh Thapa, Yun Seok Heo
Summary: This paper demonstrates a label-free and single sample drop electrochemical detection method for glucose and HbA1c. The biosensor, based on dual carbon electrodes, shows suitable sensitivity, selectivity, and efficiency, and can measure blood glucose and glycemic conditions using cheap and commercially viable methods.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Endocrinology & Metabolism
Li-Rui Kong, Yan Zhang, Feng Wu, Xue-Qin Wen, Da-Hai He, Chao-Qiong Zhou, Lin Wang
Summary: The study found that there is a discontinuous linear relationship between glycated albumin (GA) and glycosylated haemoglobin (HbA1c), and patients' long-term average blood glucose levels can be accurately estimated using two regression equations.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Pharmacology & Pharmacy
H. B. Maan, S. A. Meo, F. A. Rouq, I. M. U. Meo
Summary: High HbA1c or uncontrolled diabetes and duration of diabetes negatively impact cognitive function in type 2 diabetic patients. Monitoring HbA1c levels is crucial for managing diabetes and preventing cognitive function impairment.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Hao Sen Andrew Fang, Qiao Gao, Wei Ying Tan, Mong Li Lee, Wynne Hsu, Ngiap Chuan Tan
Summary: This study used real-world data to analyze the effect of initiating and titrating oral anti-diabetic drugs (OADs) on glycemic control in Asian patients with type 2 diabetes. The results showed that the magnitudes of OAD initiation and dose titration were slightly lower than those reported in clinical trials. These findings provide realistic expectations for physicians and patients in primary care when selecting treatment options.
Article
Endocrinology & Metabolism
David Holland, Adrian. H. H. Heald, Fahmy F. W. Hanna, Mike Stedman, Pensee Wu, Julius Sim, Christopher. J. J. Duff, Helen Duce, Lewis Green, Jonathan Scargill, Jonathon. D. D. Howe, Sarah Robinson, Ian Halsall, Neil Gaskell, Andrew Davison, Mark Simms, Angela Denny, Martin Langan, Anthony. A. A. Fryer
Summary: Studies show that the COVID-19 pandemic had a disproportionate impact on people with diabetes and those from disadvantaged backgrounds. The recovery of HbA1c testing varied, and it was associated with diabetes control and demographic characteristics.
Article
Endocrinology & Metabolism
Dikla Akselrod, Michael Friger, Aya Biderman
Summary: The study found that HbA1C variability is associated with diabetic complications in type 2 diabetic patients, and may be influenced by factors such as insulin use, age, and ischemic heart disease. By analyzing the standard deviation of HbA1C values, the study identified significant differences between the high variability group and the low variability group in terms of smoking, obesity, and visits to diabetic clinics.
DIABETOLOGY & METABOLIC SYNDROME
(2021)
Article
Pediatrics
Ulf Samuelsson, Johan Anderzen, Karin Akesson, Lena Hanberger
Summary: Children with the lowest HbA1c values during childhood tend to have the lowest HbA1c values as adults. There is a relationship between HbA1c and retinopathy, but the connection with albuminuria is less clear. Retinopathy increases with higher HbA1c values.
Article
Health Care Sciences & Services
Chin-Sheng Lin, Yung-Tsai Lee, Wen-Hui Fang, Yu-Sheng Lou, Feng-Chih Kuo, Chia-Cheng Lee, Chin Lin
Summary: This study developed a deep learning model to estimate HbA1c via ECG, showing that ECG-HbA1c could serve as a novel biomarker for screening DM and predicting the progression of DM and its complications. Stratified analysis demonstrated that ECG-HbA1c was more likely to detect diabetes in patients with fewer comorbidities. Additionally, ECG-HbA1c independently contributed to mortality, new-onset CKD, and new-onset HF, with additional impact observed in full adjustment models.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Endocrinology & Metabolism
Tawanda Chivese, Jennifer Hirst, Joshua T. Matizanadzo, Michael Custodio, Andrew Farmer, Shane Norris, Naomi Levitt
Summary: The study evaluated the diagnostic accuracy of HbA1c in screening for type 2 diabetes in Africa, showing that at certain cut-off points, HbA1c may lead to some degree of misdiagnosis.
Article
Chemistry, Multidisciplinary
Shashank Vasudevan, Janko Kajtez, Ada-Ioana Bunea, Ana Gonzalez-Ramos, Tania Ramos-Moreno, Arto Heiskanen, Merab Kokaia, Niels B. Larsen, Alberto Martinez-Serrano, Stephan S. Keller, Jenny Emneus
Article
Biochemical Research Methods
Agnieszka Mech-Dorosz, Niada Bajraktari, Claus Helix-Nielsen, Jenny Emneus, Arto Heiskanen
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2020)
Article
Biochemical Research Methods
Claudia Caviglia, Francesca Garbarino, Chiara Canali, Fredrik Melander, Roberto Raiteri, Giorgio Ferrari, Marco Sampietro, Arto Heiskanen, Thomas Lars Andresen, Kinga Zor, Jenny Emneus
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Janko Kajtez, Sebastian Buchmann, Shashank Vasudevan, Marcella Birtele, Stefano Rocchetti, Christian Jonathan Pless, Arto Heiskanen, Roger A. Barker, Alberto Martinez-Serrano, Malin Parmar, Johan Ulrik Lind, Jenny Emneus
Article
Engineering, Biomedical
Afia Asif, Silvia Gracia-Lopez, Arto Heiskanen, Alberto Martinez-Serrano, Stephan S. Keller, Marta Pereira, Jenny Emneus
ADVANCED HEALTHCARE MATERIALS
(2020)
Article
Nanoscience & Nanotechnology
Mozhdeh Ghani, Arto Heiskanen, Janko Kajtez, Babak Rezaei, Niels Bent Larsen, Peter Thomsen, Anders Kristensen, Airidas Zukauskas, Martin Alm, Jenny Emneus
Summary: This study presents a novel reversible switchable UV-triggered drug delivery system based on interpenetrating polymer networks, utilizing photo-responsive IPNs to provide a new concept for controlled drug release. The research investigates how copolymer composition and drug lipophilicity affect the release profile, and develops a thermodynamic model to optimize the polymer composition for efficient light-triggered drug release. The results demonstrate excellent light-triggered release for specific drugs and highlight the potential of the developed IPNs in drug delivery applications.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Electrochemistry
Agnieszka Mech-Dorosz, Muhammad Salman Khan, Ramona Valentina Mateiu, Claus Helix-Nielsen, Jenny Emneus, Arto Heiskanen
Summary: This study investigates the impedimetric behavior of poly(2-hydroxyethyl methacrylate) hydrogels cross-linked with poly(ethylene glycol)-dimethacrylate in different ratios. The results indicate that an increased fraction of the high-molecular weight cross-linker significantly decreases the charge transfer resistance, while the hydration degree of the hydrogels shows no statistically significant differences.
ELECTROCHIMICA ACTA
(2021)
Article
Electrochemistry
Afia Asif, Arto Heiskanen, Jenny Emneus, Stephan Sylvest Keller
Summary: Carbon microelectrodes are widely used in various applications due to their material properties. Optimized fabrication of carbon nanograss electrodes provides high surface area suitable for electrochemical applications such as biosensing or electrochemical monitoring of cells, showing an approximately 2-fold increase in electrochemical signals compared to 2D electrodes.
ELECTROCHIMICA ACTA
(2021)
Article
Chemistry, Physical
Ioannis Mantis, Suhith Hemanth, Claudia Caviglia, Arto Heiskanen, Stephan Sylvest Keller
Summary: A novel method for fabricating 3D interdigitated pyrolytic carbon microelectrodes was developed using suspended interdigitated microstructures and a dual photoresist process; 3D IDE with smaller structural dimensions exhibited behaviors similar to ultra-microelectrodes with improved electrochemical performance compared to 2D IDE.
Article
Chemistry, Multidisciplinary
Janko Kajtez, Milan Finn Wesseler, Marcella Birtele, Farinaz Riyahi Khorasgani, Daniella Rylander Ottosson, Arto Heiskanen, Tom Kamperman, Jeroen Leijten, Alberto Martinez-Serrano, Niels B. Larsen, Thomas E. Angelini, Malin Parmar, Johan U. Lind, Jenny Emneus
Summary: This article presents a modular platform for bioengineering of neuronal networks through direct embedded 3D printing of human stem cells inside Self-Healing Annealable Particle-Extracellular matrix (SHAPE) composites. The developed approach allows precise patterning of human stem cells and generation of mature subtype-specific neurons. Additionally, it enables multi-ink deposition, real-time monitoring of oxygen levels, and creation of vascular-like channels.
Article
Biochemistry & Molecular Biology
Shashank Vasudevan, Andrea Dotti, Janko Kajtez, Alberto Martinez-Serrano, Carsten Gundlach, Sandrina Campos Macas, Karin Lauschke, Anne-Marie Vinngaard, Silvia Garcia Lopez, Marta Pereira, Arto Heiskanen, Stephan S. Keller, Jenny Emneus
Summary: This study introduces a novel approach to generate Omni-LOEFs using laser ablation and demonstrates that dopamine detection current recorded from neurons differentiated on Omni-LOEFs upon light-induced stimulation is significantly higher compared to other materials.
BIOELECTROCHEMISTRY
(2023)
Article
Environmental Sciences
Naricha Pupinyo, Claudy D'Costa, Arto Heiskanen, Wanida Laiwattanapaisal, Jenny Emneus
Summary: The E-screen assay is a commonly used method for screening xenoestrogens, but it is time-consuming and involves multiple manual steps. This study presents an impedance-based E-screen cell biosensor that can rapidly and in real-time measure the estrogenic activity of test compounds, providing growth kinetic information.
Article
Nanoscience & Nanotechnology
Mozhdeh Ghani, Arto Heiskanen, Peter Thomsen, Martin Alm, Jenny Emneus
Summary: This study designed and demonstrated a photoresponsive molecular-gated drug delivery system based on silicone-hydrogel interpenetrating polymer networks, utilizing spiropyran molecules as a switchable molecular gate triggered by light for on-demand drug release. The efficiency of the system was confirmed through comparison with a control group and analysis of structural changes caused by UV light.
ACS APPLIED BIO MATERIALS
(2021)
Article
Chemistry, Analytical
Naricha Pupinyo, Arto Heiskanen, Orawon Chailapakul, Lo Gorton, Jenny Emneus, Wanida Laiwattanapaisal
SENSING AND BIO-SENSING RESEARCH
(2020)
Article
Engineering, Biomedical
Theresa S. P. Rothenbucher, Hakan Gurbuz, Marta P. Pereira, Arto Heiskanen, Jenny Emneus, Alberto Martinez-Serrano
Summary: Culturing brain organoids with a polycaprolactone scaffold for flat morphology improves diffusion conditions, prevents necrotic tissue formation, increases organoid size significantly, and allows for the observation of spontaneous gyrification.