期刊
BIOMETALS
卷 28, 期 1, 页码 1-9出版社
SPRINGER
DOI: 10.1007/s10534-014-9799-3
关键词
Copper toxicity; Neurodegeneration; Central nervous system; Cognition: Alzheimer's disease
资金
- Indian Council of medical Research, New Delhi [3/1/3/JRF-2009/HRD-13 (11279)]
Chronic copper toxicity has been long known to cause hepatotoxicity and liver cirrhosis as observed in Wilson's disease; however, substantial evidence accrued over the time have shown considerable increase in animal studies demonstrating Alzheimer's disease like pathology due to chronic copper-intoxication under certain conditions. This review integrates the contemporary mammalian studies in which the effect of chronic copper intoxication was assessed on the central nervous system and cognition of animals.
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