Article
Neurosciences
Stephanie M. Muscat, Nicholas P. Deems, Michael J. Butler, Emmanuel A. Scaria, Menaz N. Bettes, Sean P. Cleary, Ross H. Bockbrader, Steven F. Maier, Ruth M. Barrientos
Summary: This study highlights the importance of addressing perioperative neurocognitive disorders (PNDs) and provides evidence that blocking toll-like receptor 4 (TLR4) activation can mitigate the cognitive impairment caused by morphine treatment. These findings offer a promising therapeutic target for preventing or treating PNDs.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Yanping Liu, Qiang Liu, Haibi Wang, Yongkang Qiu, Jiatao Lin, Weifeng Wu, Ning Wang, Wei Dong, Jie Wan, Chen Chen, Shuai Li, Hui Zheng, Yuqing Wu
Summary: This study aimed to investigate the role of SIRT1 in cognitive impairment caused by chronic pain. The results showed that reduced SIRT1 expression in the hippocampus led to impaired synaptic plasticity and cognitive dysfunction. Increasing SIRT1 expression or enzyme activity could improve the impaired synaptic plasticity and cognitive dysfunction.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
Xueqing Chai, Xiaolin Li, Wenxin Zhang, Xiaoyue Tan, Haiyun Wang, Zhuo Yang
Summary: The study revealed that legumain knockout significantly improved cognitive function and reduced neuroinflammation in a chronic cerebral hypoperfusion mouse model. This suggests that legumain may serve as a potential target for future cerebral ischemia treatments.
Article
Multidisciplinary Sciences
Kif Liakath-Ali, Jai S. Polepalli, Sung-Jin Lee, Jean-Francois Cloutier, Thomas C. Sudhof
Summary: This study reveals the crucial role of presynaptic neurexin-ligand cerebellin-4 (Cbln4) in long-term potentiation (LTP) at EC -> DG synapses. Binding of presynaptic Cbln4 to postsynaptic neogenin-1 enables the EC -> DG synapses to undergo LTP, but is not necessary for the establishment or function of these synapses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Tobias Bock, Adrian Negrean, Steven A. Siegelbaum
Summary: Synaptic inputs targeting distal dendrites can amplify local dendritic spikes, but these spikes are often weak due to dendritic cable properties. Despite this, they are implicated in memory storage, sensory perception, and place field formation. Somatic depolarization can enhance dendritic spike propagation, leading to enhanced memory specificity and long-term synaptic plasticity in hippocampal-dependent spatial representations and learning.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Yanis Inglebert, Dominique Debanne
Summary: The importance of considering physiological levels of extracellular calcium concentration in studying functional plasticity is discussed in this study.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Douglas A. Formolo, Thomas H. Lee, Jiasui Yu, Kangguang Lin, Gang Chen, Georg S. Kranz, Suk-Yu Yau
Summary: Sub-chronic treatment with AdipoRon has antidepressant- and anxiolytic-like effects in mice, independent of changes in hippocampal neurogenesis and synaptic plasticity.
Article
Biochemistry & Molecular Biology
Kwan Young Lee, Jiuhe Zhu, Cathryn A. Cutia, Catherine A. Christian-Hinman, Justin S. Rhodes, Nien-Pei Tsai
Summary: The study reveals that the Nedd4-2 protein plays a crucial role in maintaining excitatory synapses in hippocampal neurons, allowing for long-term synaptic potentiation, and is necessary for various forms of hippocampus-dependent learning and memory. Loss of Nedd4-2 leads to decreased actin polymerization, affecting phosphorylation of cofilin and ultimately impacting hippocampal synapse function and learning capabilities. Restoring cofilin phosphorylation in Nedd4-2 knockout neurons can partially reverse the deficits in hippocampus-dependent learning, shedding light on potential therapeutic strategies for infantile spasms.
Review
Biochemistry & Molecular Biology
Nicholas H. Harbin, Sara N. Bramlett, Carolina Montanez-Miranda, Gizem Terzioglu, John R. Hepler
Summary: RGS14 is a multifunctional signaling protein that regulates post synaptic plasticity in neurons. It integrates multiple signaling pathways at the cellular level to suppress long-term potentiation and structural plasticity, while also possibly influencing spine morphogenesis. Additionally, RGS14 plays a role in behavior and its balance of nuclear shuttling and dendritic spine localization are essential for its neuronal functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Wei-Feng Wu, Jia-Tao Lin, Yong-Kang Qiu, Shuai Li, Hui Zheng, Yu-Qing Wu
Summary: With the ageing of the population, the health problems of elderly individuals have become particularly important. Through a large number of clinical studies and trials, it has been confirmed that elderly patients can experience postoperative cognitive dysfunction after general anesthesia/surgery. However, the mechanism of postoperative cognitive dysfunction is still unknown. In recent years, the role of epigenetics in postoperative cognitive dysfunction has been widely studied and reported. This article summarizes the epigenetic mechanism of cognitive impairment after general anesthesia/surgery and analyses the broad prospects of epigenetics as a therapeutic target for postoperative cognitive dysfunction.
AGEING RESEARCH REVIEWS
(2023)
Article
Neurosciences
Guangyan Xu, Tianjia Li, Yuguang Huang
Summary: This study aimed to evaluate the effects of intraoperative hypothermia on postoperative cognitive function in rats and investigate the possible mechanisms. The results suggest a correlation between intraoperative hypothermia and POCD in rats, which may result in impairments in spatial working memory, spatial learning, and memory.
Article
Cell Biology
Wenhui Yan, Tingli Guo, Na Liu, Xin Cui, Xiaotong Wei, Yuzhuo Sun, Hao Hu, Lina Chen
Summary: Recent studies have demonstrated that EPO exerts neuroprotective and neurotrophic effects on neurological disorders. However, the potential benefits of EPO on diabetic cognitive impairments have not been well studied. In this research, the authors investigated the effects of EPO on diabetic mice and HT22 cells. They found that EPO treatment improved cognitive impairments, lowered blood glucose levels, and alleviated damage in both the pancreas and hippocampus. EPO also regulated the expression of various factors related to cell survival and apoptosis in HT22 cells. The findings suggest that EPO plays a protective role in diabetic cognitive impairments by modulating BDNF and PSD-95 expression via NMDA receptors.
CELLULAR SIGNALLING
(2023)
Article
Neurosciences
Tianhai Wang, Guiping Xu, Xue Zhang, Yanghao Ren, Tianyu Yang, Cheng Xiao, Chunyi Zhou
Summary: Postoperative delirium is a serious health problem occurring after major surgery. The study found that malfunctioned astrocytes in the hippocampus contribute to cognitive dysfunction in postoperative delirium. The study suggests that targeting astrocyte activation and acetylcholine receptors may be a valuable strategy for intervention.
Article
Biology
Yuri Elias Rodrigues, Cezar M. Tigaret, Helene Marie, Cian O'Donnell, Romain Veltz
Summary: Discovering the rules of synaptic plasticity is crucial for understanding brain learning. Existing models either lack flexibility to fit experimental data or are too complex to interpret. To overcome these limitations, we propose a new plasticity rule based on a geometrical readout mechanism that accurately predicts plasticity outcomes. Our model successfully reproduces various experimental conditions and suggests that spike timing irregularity strongly affects plasticity outcome. This modelling approach can be applied to other synapses to discover their plasticity rules.
Article
Neurosciences
Yixing Du, Faith H. Brennan, Phillip G. Popovich, Min Zhou
Summary: This study investigates the role of microglia in regulating the structure and function of astrocytes in the mouse hippocampus, revealing that depletion of microglia disrupts astrocyte syncytial isopotentiality and dye coupling, leading to reduced synaptic transmission in neurons. Activation of microglia enhances synaptic transmission, while leaving astrocyte network function unaffected.
Article
Neurosciences
Ignacio Negron-Oyarzo, Alexies Dagnino-Subiabre, Pablo Munoz Carvajal
FRONTIERS IN CELLULAR NEUROSCIENCE
(2015)
Article
Neurosciences
Pablo Munoz, Carolina Estay, Paula Diaz, Claudio Elgueta, Alvaro O. Ardiles, Pablo A. Lizana
Article
Geriatrics & Gerontology
Alejandra Arias-Cavieres, Tatiana Adasme, Gina Sanchez, Pablo Munoz, Cecilia Hidalgo
FRONTIERS IN AGING NEUROSCIENCE
(2017)
Article
Neurosciences
Ivana Gajardo, Claudia S. Salazar, Daniela Lopez-Espindola, Carolina Estay, Carolina Flores-Munoz, Claudio Elgueta, Arlek M. Gonzalez-Jamett, Agustin D. Martinez, Pablo Munoz, Alvaro O. Ardiles
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2018)
Article
Behavioral Sciences
Ignacio Negron-Oyarzo, Miguel Angel Perez, Gonzalo Terreros, Pablo Munoz, Alexies Dagnino-Subiabre
BEHAVIOURAL BRAIN RESEARCH
(2014)
Article
Neurosciences
Alvaro O. Ardiles, Carolina Flores-Munoz, Gabriela Toro-Ayala, Ana M. Cardenas, Adrian G. Palacios, Pablo Munoz, Marco Fuenzalida, Juan C. Saez, Agustin D. Martinez
FRONTIERS IN CELLULAR NEUROSCIENCE
(2014)
Article
Neurosciences
Alejandra Arias-Cavieres, Genaro C. Barrientos, Gina Sanchez, Claudio Elgueta, Pablo Munoz, Cecilia Hidalgo
FRONTIERS IN CELLULAR NEUROSCIENCE
(2018)
Article
Neurosciences
Carolina Flores-Munoz, Barbara Gomez, Elena Mery, Paula Mujica, Ivana Gajardo, Claudio Cordova, Daniela Lopez-Espindola, Claudia Duran-Aniotz, Claudio Hetz, Pablo Munoz, Arlek M. Gonzalez-Jamett, Alvaro O. Ardiles
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Physiology
Ricardo Ramirez-Barrantes, Karina Carvajal-Zamorano, Belen Rodriguez, Claudio Cordova, Carlo Lozano, Felipe Simon, Paula Diaz, Pablo Munoz, Ivanny Marchant, Ramon Latorre, Karen Castillo, Pablo Olivero
FRONTIERS IN PHYSIOLOGY
(2020)
Article
Chemistry, Medicinal
Francisca Garcia, Pedro Lobos, Alejandra Ponce, Karla Cataldo, Daniela Meza, Patricio Farias, Carolina Estay, Felipe Oyarzun-Ampuero, Rodrigo Herrera-Molina, Andrea Paula-Lima, Alvaro O. Ardiles, Cecilia Hidalgo, Tatiana Adasme, Pablo Munoz
Review
Cell Biology
Pablo Munoz, Alvaro O. Ardiles, Boris Perez-Espinosa, Cristian Nunez-Espinosa, Andrea Paula-Lima, Christian Gonzalez-Billault, Yolanda Espinosa-Parrilla
MECHANISMS OF AGEING AND DEVELOPMENT
(2020)
Article
Neurosciences
Debora Buendia, Tatiana Guncay, Macarena Oyanedel, Makarena Lemus, Alejandro Weinstein, Alvaro O. Ardiles, Jose Marcos, Adriana Fernandes, Renato Zangaro, Pablo Munoz
Summary: This study evaluated the effects of transcranial light therapy on synaptic plasticity and cognitive functions in an Alzheimer's disease animal model. The results suggest that TLTC may be an effective non-invasive treatment for AD-associated synaptic plasticity deficits.
Review
Biochemistry & Molecular Biology
Jose Luis Marcos, Rossy Olivares-Barraza, Karina Ceballo, Melisa Wastavino, Victor Ortiz, Julio Riquelme, Jonathan Martinez-Pinto, Pablo Munoz, Gonzalo Cruz, Ramon Sotomayor-Zarate
Summary: Obesity-induced neuroinflammation is a chronic inflammation in the central nervous system characterized by increased pro-inflammatory cytokines and the activation of the NLRP3 inflammasome. It is caused by lifestyle changes such as excessive intake of obesogenic foods and decreased physical activity. Chronic lipid intake triggers neuroinflammation in multiple brain regions, affecting feeding control and leading to metabolic and neurological alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Ismael Valdes-Undurraga, Pedro Lobos, Virginia Sanchez-Robledo, Alejandra Arias-Cavieres, Carol D. SanMartin, Genaro Barrientos, Jamileth More, Pablo Munoz, Andrea Cristina Paula-Lima, Cecilia Hidalgo, Tatiana Adasme
Summary: By manipulating the calcium signals at synapses, it is possible to enhance long-term potentiation (LTP) and spatial memory. It has been found that LTP induction through Theta burst stimulation protocols increases the protein levels of RyR2 in the hippocampus of rats. Inhibiting the activity of RyR channels leads to the disappearance of LTP and a decrease in synapse density. Additionally, training rats in the Morris water maze also increases the gene expression and protein content of RyR2. These findings suggest that RyR channels play a significant role in hippocampal synaptic plasticity and spatial memory consolidation.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Letter
Medicine, General & Internal
Alvaro O. Ardiles, Marcelo Arancibia, Mariane Lutz, Julio Riquelme, Juan Pablo Gigoux, Pablo Munoz
REVISTA MEDICA DE CHILE
(2021)