Article
Oncology
Eva Andreuzzi, Albina Fejza, Maurizio Polano, Evelina Poletto, Lucrezia Camicia, Greta Carobolante, Giulia Tarticchio, Federico Todaro, Emma Di Carlo, Melania Scarpa, Marco Scarpa, Alice Paulitti, Alessandra Capuano, Vincenzo Canzonieri, Stefania Maiero, Mara Fornasarig, Renato Cannizzaro, Roberto Doliana, Alfonso Colombatti, Paola Spessotto, Maurizio Mongiat
Summary: This study reveals the importance of EMILIN-2 in the development and prognosis of colorectal cancer. Loss of EMILIN-2 is associated with increased tumor numbers and altered immune cell populations in CRC models. Mechanistically, EMILIN-2 regulates macrophage polarization through the Toll-like Receptor 4/MyD88/NF-kappa B pathway. Furthermore, EMILIN-2 expression levels are correlated with the prognosis of CRC patients.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Fisheries
Simone Andrea de Assis Beneti, Ingrid Camargo dos Reis, Camino Fierro-Castro, Basia Schlichting Moromizato, Gustavo do Valle Polycarpo, Celso Tadao Miasaki, Jaqueline Dalbello Biller
Summary: This study evaluated the effect of beta-glucan on gene transcription mechanisms via the Tlr-Myd88-Nfkb1 pathway in Nile tilapia under stress. The results showed that beta-glucan, combined with stressful management, modulated the immune system and promoted early defense in fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Plant Sciences
Yuxin Dai, Qiulu Lu, Peiyi Li, Junyu Zhu, Jiaxin Jiang, Tong Zhao, Yue Hu, Kang Ding, Min Zhao
Summary: This study aimed to investigate the mechanism of Xianglian Pill (XLP) in treating ulcerative colitis (UC) induced by dextran sulfate sodium (DSS). The results showed that XLP treated UC by regulating the TLR4/MyD88/NF-kappa B signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Review
Genetics & Heredity
Meiqi Liu, Zhizhong Hu, Chengkun Wang, Yang Zhang
Summary: Helicobacter pylori-induced chronic gastritis is a well-known risk factor for gastric cancer. However, the mechanism by which H. pylori-induced inflammation leads to GC development is not clear. Toll-like receptors (TLRs) play a key role in the innate immune response and their signaling has been implicated in the pathogenesis of inflammation-associated cancers. In this review, we discuss the regulatory mechanisms of the TLR/MyD88 signaling pathway and its downstream molecules in H. pylori infection-induced GC, with a focus on understanding the immunomolecular mechanisms of pathogen recognition and innate immune system activation in the tumor microenvironment (TME) of inflammation-associated GC.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Fisheries
Alianet Rodriguez, Janet Velazquez, Luis Gonzalez, Tania Rodriguez-Ramos, Brian Dixon, Fidel Herrera Miyares, Antonio Morales, Osmany Gonzalez, Mario Pablo Estrada, Yamila Carpio
Summary: PACAP-38 from African catfish enhances antibacterial activity and modulates gene expression of immune-related molecules, suggesting its potential as an antimicrobial agent in aquaculture.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Antonios N. Gargalionis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou
Summary: STAT3 plays a critical role in the development of colorectal cancer by enhancing tumor cell proliferation and growth through inflammatory mechanisms. However, the mechanisms underlying the role of STAT3 in tumor immunity are not fully understood, and STAT3 inhibitors have not yet been widely used in clinical practice.
Article
Developmental Biology
Laura F. Bennett, Melanie D. Mumau, Yan Li, Nancy A. Speck
Summary: The study reveals that MyD88-dependent toll like receptor (TLR) signaling regulates the numbers of lympho-myeloid biased progenitors (LMPs) and adult-repopulating hematopoietic stem cells (HSCs) in hemogenic endothelial cells and intra-arterial hematopoietic clusters.
Article
Chemistry, Medicinal
Jie Huang, Tiantian Wu, Youbao Zhong, Jiaqi Huang, Zengping Kang, Bugao Zhou, Haimei Zhao, Duanyong Liu
Summary: Curcumin can regulate the differentiation and function of Breg cells to alleviate chronic colitis by inhibiting the TLR/MyD88 signaling pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Tae Yoon Kim, Jong Min Kim, Hyo Lim Lee, Min Ji Go, Seung Gyum Joo, Ju Hui Kim, Han Su Lee, Dong Yeol Lee, Hyun-Jin Kim, Ho Jin Heo
Summary: This study confirms that the aqueous extract of Codium fragile (AECF) improves cognitive dysfunction in chronic particulate matter (PM2.5)-exposed mice by regulating the gut-brain axis imbalance. The physiological compounds in AECF were identified and found to contribute to its ameliorating effects. AECF improved the antioxidant system, gut microbiome, intestinal barrier function, inflammation, apoptosis, mitochondrial function, and cholinergic system, ultimately improving cognitive function impaired by PM2.5 exposure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Jung Woong Yoon, Sangsu Shin, JeongWoong Park, Bo Ram Lee, Sang In Lee
Summary: This study aimed to demonstrate that OTA regulates TLR/MyD88 signaling in IPEC-J2 cells and induces barrier function impairment through tight junction reduction. MyD88 inhibition alleviated inflammatory cytokine levels, tight junction reduction, and damage to barrier function due to OTA. Our findings provide a molecular understanding of OTA toxicity in porcine intestinal epithelial cells.
Article
Pharmacology & Pharmacy
Sae-Bom Yoon, Hyowon Hong, Hee-Jong Lim, Ji Hye Choi, Yoon Pyo Choi, Seong Wook Seo, Hyuk Woo Lee, Chong Hak Chae, Woo-Kyu Park, Hyun Young Kim, Daeyoung Jeong, Tran Quang De, Chang-Seon Myung, Heeyeong Cho
Summary: IRAK4 plays a key role in the TLR/MYD88 signaling pathway and is highly activated in rheumatoid arthritis tissues and ABC-DLBCL. IRAK4 activation promotes B-cell proliferation and lymphoma aggressiveness. We developed a dual IRAK4/PIM1 inhibitor, KIC-0101, which effectively suppresses the NF-KB pathway and proinflammatory cytokine induction in vitro and in vivo. KIC-0101 shows promising results in treating autoimmune diseases and ibrutinib-resistant B-cell lymphomas.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Medicine, Research & Experimental
Awaguli Dawuti, Shuchan Sun, Ranran Wang, Difei Gong, Ruiqi Liu, Dewen Kong, Tianyi Yuan, Jian Zhou, Yang Lu, Shoubao Wang, Guanhua Du, Lianhua Fang
Summary: This study found that salvianolic acid A (SAA) has therapeutic activity against heart failure with preserved ejection fraction (HFpEF) in mice. SAA reduces risk factors of HFpEF, improves exercise tolerance, alleviates myocardial hypertrophy and fibrosis, and enhances cardiac diastolic function. Moreover, SAA attenuates cardiac inflammation by inhibiting TLR2/TLR4-mediated Myd88 activation and its downstream molecules TRAF6 and IRAK4 through NF-κB and p38 MAPK pathways.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Charlie Hatcher, George Richenberg, Samuel Waterson, Long H. Nguyen, Amit D. Joshi, Robert Carreras-Torres, Victor Moreno, Andrew T. Chan, Marc Gunter, Yi Lin, Conghui Qu, Mingyang Song, Graham Casey, Jane C. Figueiredo, Stephen B. Gruber, Jochen Hampe, Heather Hampel, Mark A. Jenkins, Temitope O. Keku, Ulrike Peters, Catherine M. Tangen, Anna H. Wu, David A. Hughes, Malte C. Ruehlemann, Jeroen Raes, Nicholas J. Timpson, Kaitlin H. Wade
Summary: This study applies Mendelian randomization to investigate the causal relationship between the gut microbiome and colorectal cancer. The results suggest that higher abundance of Bifidobacterium and presence of an unclassified group of bacteria in the Bacteroidales order increase the risk of colorectal cancer. However, sensitivity analyses indicate that caution is needed when interpreting the results due to potential confounding factors.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Liang Ma, Jianguo Song, Xueping Chen, Duan Dai, Jianping Chen, Liwen Zhang
Summary: This study found that therapeutic FMT can reverse liver injury and TFR/TFH cell imbalance in autoimmune hepatitis through the TLR4/11-MyD88 signaling pathway.
Article
Biochemistry & Molecular Biology
Yuyuan Zi, Liyu Liu, Jie Gao, Xu Xu, Yidi Guan, Zhuoxian Rong, Zhen Cao, Mengwei Li, Zimei Zeng, Qi Fan, Feiyu Tang, Junju He, Dan Feng, Jionghuang Chen, Yuedi Dai, Yufeng Huang, Yingjie Nie, Haiping Pei, Qingping Cai, Zhi Li, Lunquan Sun, Yuezhen Deng
Summary: This study finds that pancreatic progenitor cell differentiation and proliferation factor (PPDPF) is upregulated in colorectal cancer (CRC) and is significantly correlated with TNM stages and survival time. Knockout of PPDPF in the intestinal epithelium shortens crypts, decreases the number of stem cells, and inhibits CRC occurrence. Mechanistically, PPDPF interacts with CK1 alpha, disrupting its binding to Axin and activating the Wnt/beta-catenin pathway. Inflammatory signals mediated by IL6/JAK2 phosphorylate PPDPF, stabilizing the protein. Overall, PPDPF is a key molecule connecting inflammation to the Wnt/beta-catenin signaling pathway in CRC carcinogenesis and progression, suggesting it as a potential therapeutic target.
Review
Medicine, Research & Experimental
Lu Wang, Qingzhu Zhang
BIOMEDICINE & PHARMACOTHERAPY
(2015)
Article
Oncology
Lu Wang, Yan Wang, Yuyin Lu, Qianyun Zhang, Xianjun Qu
CANCER BIOLOGY & THERAPY
(2015)
Article
Biochemistry & Molecular Biology
Lu Wang, Yan Wang, Zhiyu Song, Jiahui Chu, Xianjun Qu
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2015)
Review
Nutrition & Dietetics
Lu Wang, Haiyan Wu, Fei Yang, Wenbin Dong
JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY
(2019)
Review
Medicine, Research & Experimental
Xinru Han, Xiang Zhang, Qian Wang, Lu Wang, Shuwen Yu
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Review
Medicine, Research & Experimental
Shuangshuang Li, Min Jiang, Lu Wang, Shuwen Yu
BIOMEDICINE & PHARMACOTHERAPY
(2020)
Review
Medicine, Research & Experimental
Lu Wang, Qi Lu, Wenwen Gao, Shuwen Yu
Summary: Macrophages are a vital component of the immune system, with different types exerting varying effects on tumors and diseases. Current research focuses on the impact of drugs on macrophage polarization and the associated molecular mechanisms.
Review
Pharmacology & Pharmacy
Huimin Sun, Wen Meng, Jie Zhu, Lu Wang
Summary: Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays an important role in regulating cholesterol metabolism and lipoprotein homeostasis. In addition to its role in cardiovascular diseases, PCSK9 has been found to be involved in tumor development and progression. Inhibition of PCSK9 can attenuate tumor progression and promote apoptosis of cancer cells.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Huihui Ding, Gongfu Wang, Zhen Yu, Huimin Sun, Lu Wang
Summary: IFN-?? is a soluble cytokine that activates the JAK-STAT pathway to induce expression of IFN-??-stimulated genes, playing critical roles in innate and adaptive immunity. However, its role in cancer development is complex and depends on the tissue microenvironment. This review evaluates the polymorphisms, expression, and functions of IFN??R in various human diseases and discusses factors that regulate IFN??R expression, drug resistance, and therapeutic strategies.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Lu Wang, Shuangshuang Li, Huanhua Luo, Qi Lu, Shuwen Yu
Summary: This study found that PCSK9 plays an important role in the progression and metastasis of colon cancer by regulating tumor cell EMT and PI3K/AKT signaling, as well as the phenotypic polarization of macrophages by mediating MIF and lactate levels.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Immunology
Kai Yang, Jie Zhu, Huan-hua Luo, Shu-wen Yu, Lu Wang
Summary: The study demonstrated that PCSK9 may have a potential oncogenic role in the development and progression of colorectal cancer in vivo via activation of JAK2/STAT3/SOCS3 signaling pathway. Overexpression of PCSK9 led to increased adenomas and adenocarcinomas in mice, while treatment with evolocumab reduced tumor growth and prevented the development of adenocarcinomas.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Immunology
Wenwen Gao, Xiang Zhang, Yanhui Yin, Shuwen Yu, Lu Wang
Summary: The study found that there was no significant difference in the eradication rate of Helicobacter pylori and adverse events between high-dose and standard-dose new generation proton pump inhibitors. This similarity was observed in both Asian and Caucasian populations, as well as in strains with clarithromycin-resistance. Further research is needed to confirm these findings.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Ming-liang Zhu, Pei-min Zhang, Min Jiang, Shu-wen Yu, Lu Wang
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2020)
Review
Chemistry, Medicinal
Mingliang Zhu, Kewei Yu, Lu Wang, Shuwen Yu
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)