Article
Oncology
Yalin Lu, Gaochao Guo, Rujun Hong, Xingjie Chen, Yan Sun, Fang Liu, Zhimeng Zhang, Xun Jin, Jun Dong, Kai Yu, Xuejun Yang, Yang Nan, Qiang Huang
Summary: In this study, it was found that lncRNA HAS2-AS1 is upregulated in GBM cell lines and predominantly localized in the cytoplasm. High expression of HAS2-AS1 in vitro promoted proliferation, while knockdown of HAS2-AS1 significantly inhibited proliferation. Additionally, HAS2-AS1 acted as a ceRNA for miR-137, leading to the derepression of its downstream target LSD1.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yuan Chen, Yiting Geng, Junchao Huang, Dan Xi, Guoping Xu, Wendong Gu, Yingjie Shao
Summary: The study identified that circNEIL3 is highly expressed in cervical cancer and enhances the proliferation capacity of cervical cancer cells. Further experiments confirmed that circNEIL3 interacts with miR-137 to upregulate KLF12, thereby promoting the proliferation of cervical cancer cells.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Shuwen Xu, Xiaofeng Li, Longfei Li, Yufeng Wang, Chong Geng, Feng Guo, Tao Zhang, Aonan Du, Zhiwei Lu, Hua Hui, Qiang Wang
Summary: The study found that miR-137 was down-regulated in ESCC cells. Upregulation of miR-137 inhibited proliferation, migration, invasion, and EMT of ESCC cells. CTCF activated miR-137 transcription and its downstream targets included EZH2 and PXN.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Wenzhen Zhang, Bing Sun, Yanqing Zhao, Sayed Haidar Abbas Raza, Yishu Li, Jianfang Wang, Xinhao Ma, Hailah M. Almohaimeed, Sameerah Shaheen, Faisal Al-Sarraj, Raed Albiheyri, Chugang Mei, Linsen Zan
Summary: This study identified a novel long noncoding RNA (lncPRRX1) that promotes bovine myoblast proliferation by regulating the miR-137/CDC42 axis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Pharmacology & Pharmacy
Baeksun Kim, Sung Hyun Tag, Eunjoo Nam, Suji Ham, Sujin Ahn, Juhwan Kim, Doo-Wan Cho, Sangjoon Lee, Young-Su Yang, Seung Eun Lee, Yong Sik Kim, Il-Joo Cho, Kwang Pyo Kim, Su-Cheol Han, Heh-In Im
Summary: Abstinence from prolonged psychostimulant use leads to stimulant withdrawal syndrome characterized by molecular adaptations within the dorsal striatum. This study reveals that circulating miR-137 could serve as a potential blood-based marker for reflecting the changes in the striatal miR-137/SYNCRIP axis in methamphetamine-induced abstinence. The downregulation of SYNCRIP in the dorsal striatum may contribute to the cognitive dysfunction associated with methamphetamine withdrawal syndrome.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Oncology
Yizhuo Lu, Long Li, Lianghui Li, Guoyang Wu, Guoyan Liu
Summary: This study revealed that circHECTD1 is up-regulated in gastric cancer tissues and cells, and may play a crucial role in gastric cancer treatment.
CANCER CELL INTERNATIONAL
(2021)
Article
Orthopedics
Xiaofeng Wang, Zhiwen Zhang, Haofeng Liang, Ruixiong Chen, Yuliang Huang
Summary: The levels of circ_0025908 and HIPK2 were upregulated, and the miR-137 level was decreased in RA tissues. Circ_0025908 deficiency inhibited cell vitality, cell mitotic cycle, cell proliferation, and immunoreaction in RA cells, whereas promoted cell apoptosis. MiR-137 was confirmed to repress the progression of RA cells by suppressing HIPK2.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Genetics & Heredity
Heyuan Zhang, Nanhui Chen, Zhihai Deng, Yang Mai, Limin Deng, Guo Chen, Yutong Li, Bin Pan, Weifeng Zhong
Summary: The study found that ANT2 expression was significantly upregulated in PCa tissues, while miR-137 expression was reduced. Overexpression of ANT2 promoted proliferation, migration, and invasion of PCa cells, whereas miR-137 mimics inhibited these behaviors by antagonizing expression of ANT2. This suggests that ANT2, a target gene of miR-137, plays a role in the development of PCa and may provide new options for targeted therapy.
FRONTIERS IN GENETICS
(2021)
Article
Environmental Sciences
Qinying Ye, Zhenpei Zeng, Xiaodong Liang, Wenting Li
Summary: This study demonstrates that quercetin can inhibit proliferation and invasion, and induce apoptosis and oxidative stress in RB cells through modulation of the miR-137/FNDC5 pathway. These findings provide a novel and effective approach for RB treatment.
ENVIRONMENTAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Sepideh Razi, Asieh Sadeghi, Zeynab Asadi-Lari, Kevin J. Tam, Elham Kalantari, Zahra Madjd
Summary: The study found a significant negative correlation between DCLK1 expression and miR-137 and miR-15a levels in colorectal cancer. DCLK1 may serve as a marker for colorectal cancer stem cells and potentially play a critical role in tumor diagnosis and treatment.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Environmental Sciences
Yue Wang, Yubing Guo, Yanyuan Lu, Yeqing Sun, Dan Xu
Summary: Endosulfan promotes cell migration and invasion in prostate cancer cells through the epigenetic mechanism of lncRNA-miRNA regulation, specifically involving the KCNQ1OT1/miR-137-3p/PTP4A3 axis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biochemistry & Molecular Biology
Salwa A. Elgebaly, W. Frank Peacock, Robert H. Christenson, Donald L. Kreutzer, Ahmed Hassan Ibrahim Faraag, Amir Mahfouz Mokhtar Sarguos, Nashwa El-Khazragy
Summary: This study investigates the potential of microRNAs (miRNAs) related to the Nourin protein for diagnosing myocardial ischemia in unstable angina patients. The study identifies miR-137 and miR-106b as potential diagnostic biomarkers for acute coronary syndrome (ACS). The analysis also establishes strong interactions between Nourin and miR-137/hsa-miR-106b, supporting the use of miRNA-based interventions in ischemic injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ying Gui, Lina Wang, Zhihong Huang
Summary: The study found that miR-137 was down-regulated and Notch1 was up-regulated in cervical cancer cells. MiR-137 partially impeded cervical cancer progression through regulation of the Notch1 and PI3K/AKT/mTOR axis.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Oncology
Dong-Mei Li, Qiu-Dan Chen, Gui-Ning Wei, Jie Wei, Jian-Xing Yin, Jun-Hui He, Xin Ge, Zhu-Mei Shi
Summary: The study revealed that miR-137 is suppressed in GBM, inhibiting cell invasion and enhancing chemosensitivity by targeting LRP6. Hypoxia-induced miR-137 methylation leads to suppression of miR-137, causing enhanced chemoresistance and poor prognosis in GBM.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Yipei Li, Li Jin, Fang Wang, Li Ren, Ruirui Pen, Guojia Bo, Li Wang
Summary: This study suggests that the epigenetic axis of SNHG19/hsa-miR-137/TNFAIP1 may functionally regulate A beta(25-35)-induced SH-SY5Y cytotoxicity, making it a potential molecular target for Alzheimer's disease treatment.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)