Article
Multidisciplinary Sciences
Catalin-Bogdan Satala, Ioan Jung, Zsolt Kovacs, Raluca-Ioana Stefan-Van Staden, Calin Molnar, Tivadar Bara, Andrei-Ionut Patrichi, Simona Gurzu
Summary: In gastric cancer, V-set and Immunoglobulin domain containing 1 (VSIG1) plays an important role in the genesis and evolution of the cancer. The study found that the expression of VSIG1 is associated with the clinicopathological features and overall survival of gastric cancer patients. The membrane-cytoplasmic translocation of VSIG1 may serve as an indicator of epithelial-mesenchymal transition in gastric cancer.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Sandeep Surendra Panikar, Shayla Shmuel, Jason S. Lewis, Patricia M. R. Pereira
Summary: In this study, radiolabeled and fluorescently labeled anti-CAV1 antibodies were developed and tested as imaging agents for detecting CAV1 in HER2-positive/CAV1-high gastric tumors. The results showed that these imaging agents could effectively localize and detect CAV1 expression in gastric tumors.
Article
Cell Biology
Weihong Xu, Yanan Lai, Yunqi Pan, Meiyu Tan, Yanyun Ma, Huiming Sheng, Jiucun Wang
Summary: The study found that NDUFA4 is highly expressed in gastric cancer and is associated with poor prognosis. Inhibition of NDUFA4 can reduce cell proliferation and tumor growth. NDUFA4 promotes glycolysis and mitochondrial fission in gastric cancer cells, and inhibition of glycolysis can suppress tumor growth. Moreover, METTL3 can increase the expression of NDUFA4 by increasing the m6A level of NDUFA4 mRNA.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Serena Battista, Maria Raffaella Ambrosio, Francesco Limarzi, Graziana Gallo, Luca Saragoni
Summary: The article reviews the diagnostic and prognostic values of molecular markers in gastric cancer, focusing on the correlation between molecular alterations and prognosis in preinvasive neoplasia and early gastric cancer, as well as the (immuno)histochemical characterization of diffuse-type gastric cancer. The aim is to evaluate suitable biomarkers used in the pre-surgical phase for distinguishing patients with different prognoses and determining the best therapeutic strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Fernanda Wisnieski, Jaqueline Cruz Geraldis, Leonardo Caires Santos, Mariana Ferreira Leal, Danielle Queiroz Calcagno, Carolina Oliveira Gigek, Elizabeth Suchi Chen, Ana Carolina Anauate, Ricardo Artigiani, Samia Demachki, Paulo Pimentel Assumpcao, Laercio Gomes Lourenco, Carlos Haruo Arasaki, Julie Krainer, Stephan Pabinger, Rommel Rodriguez Burbano, Marilia Arruda Cardoso Smith
Summary: In this study, the research group identified a list of 83 genes potentially modulated by DNA methylation in GC cell lines, with LRRC37A2 playing a role in undifferentiated and poorly differentiated tumors. The study showed that reduced LRRC37A2 mRNA levels and increased LRRC37A2 exon methylation are associated with GC progression, emphasizing the potential utility of gene-related stratification for epigenetic therapy in GC patients.
Article
Multidisciplinary Sciences
Marwa Sayed Abdel-Tawab, Hanan Fouad, Asmaa M. Othman, Ragaey A. Eid, Marwa Abdeltawab Mohammed, Ahmed Hassan, Hoda Ramadan Reyad
Summary: This study assessed the association of PLEKHS1, AADAC, and CDKN3 genes with GC and found that their gene expressions were correlated with tumor stage, grade, and other clinicopathological features. PLEKHS1 gene was downregulated, while AADAC and CDKN3 genes were upregulated in GC group. The expression of AADAC gene was positively correlated with tumor grade and stage. These gene expressions can be used as diagnostic, predictive, and prognostic biomarkers of GC.
Article
Biochemistry & Molecular Biology
Xiaoxiao Ma, Shuqin Jia, Gangjian Wang, Min Liang, Ting Guo, Hong Du, Sisi Li, Xiaomei Li, Longtao Huangfu, Jianping Guo, Xiaofang Xing, Jiafu Ji
Summary: Using CRISPR-Cas9 screening, TRIM28 was identified as a significant regulator of PD-L1 in gastric cancer cells. TRIM28 stabilizes PD-L1 by inhibiting its ubiquitination and promoting SUMOylation. TRIM28 also activates TBK1-IRF1 and TBK1-mTOR pathways, enhancing PD-L1 transcription. High TRIM28 expression correlates with poor prognosis in gastric cancer patients. Ectopic TRIM28 expression promotes tumor growth, increases PD-L1 expression, and suppresses T cell activation. Combining TBK1 inhibitor with CTLA4 immune checkpoint blockade synergistically affects gastric cancer therapy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Physiology
Sukanta S. S. Bhattacharya, Brijesh Yadav, Ekta Yadav, Ariel Hus, Niket Yadav, Perminder Kaur, Lauren Rosen, Roman Jandarov, Jagjit S. Yadav
Summary: The understanding of biomarkers and their underlying mechanisms for toxic chemicals and particulates, such as engineered nanoparticles and chlorine gas, is limited. This study focused on the regulation of aquaporins (AQPs), also known as water channels, in lung injuries caused by different toxicity models. The results showed toxicity model-specific regulation of AQPs, indicating their potential as predictive markers for toxicant-specific pulmonary injury.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Cheng Tang, Xiong Lei, Lingqiang Xiong, Zhigao Hu, Bo Tang
Summary: The study revealed that upregulated POU1F1 in both GC tissues and cell lines was positively correlated with poor prognosis. POU1F1 promoted GC progression by regulating macrophage proliferation, migration, polarization, and angiogenesis in a CXCL12/CXCR4-dependent manner. Furthermore, POU1F1 also promoted GC metastasis in the lung by modulating macrophage polarization via the CXCL12/CXCR4 axis in vivo.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Georg Bauer
Summary: The human gastric carcinoma cell line MKN-45 is protected from apoptosis-inducing signaling pathways by a membrane-associated catalase, but full apoptosis induction requires intrusion of extracellular H2O2 through aquaporins. Inhibition of aquaporins, NOX1, and H2O2 decomposition can prevent this secondary step in apoptosis induction. Understanding the interactions between ROS/RNS signaling, aquaporins/H2O2 sensitizing effects, and the xC transporter/glutathione synthase system is crucial for selective apoptosis induction in tumor cells.
Article
Multidisciplinary Sciences
Hua Ma, Zhihui He, Jing Chen, Xu Zhang, Pingping Song
Summary: This study identified 11 hub genes associated with gastric cancer, with functions enriched in cellular senescence, cell cycle, viral carcinogenesis, and the p53 signaling pathway. Ten of these genes were found to be related to overall survival in GC patients, and seven were significantly correlated with GC, potentially serving as prognostic biomarkers.
SCIENTIFIC REPORTS
(2021)
Article
Pathology
Seokhwi Kim, Won Jung Bae, Ji Mi Ahn, Jin-Hyung Heo, Kyoung-Mee Kim, Kyeong Woon Choi, Chang Ohk Sung, Dakeun Lee
Summary: The study identified unique miRNA expression profiles that can predict metastasis in intramucosal carcinomas (IMCs), with most miRNAs showing stepwise increased or decreased expression. A machine-learning algorithm could distinguish metastatic IMC from nonmetastatic IMC, and gene ontology and pathway analysis revealed enrichment of key signaling pathways. Furthermore, immunohistochemical staining indicated differential expression of pathway components between metastatic and nonmetastatic IMC.
Article
Oncology
So Young Kang, You Jeong Heo, Ghee Young Kwon, Kyoung-Mee Kim
Summary: This study aimed to test the feasibility of using quantitative reverse transcription-polymerase chain reaction (qRT-PCR) to measure PD-L1 (CD274) mRNA expression levels and compared the results with PD-L1 IHC. The results showed a good correlation between CD274 mRNA levels and PD-L1 expression, and patients with high CD274 mRNA levels had better responses to ICI treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hailing Shao, Shichu Gao, Xinxin Ying, Xueqiong Zhu, Ying Hua
Summary: Aquaporins are small hydrophobic integral membrane proteins that facilitate rapid transport of water and small solutes. Abnormal expressions of AQPs are linked to various pregnancy complications and reproductive dysfunctions, making them potential therapeutic targets for related diseases.
DNA AND CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Malin Tordis Meyer, Christoph Watermann, Thomas Dreyer, Steffen Wagner, Claus Wittekindt, Jens Peter Klussmann, Suleyman Erguen, Eveline Baumgart-Vogt, Srikanth Karnati
Summary: Studies have shown differences in peroxisomal dynamics in different morphologies of parotid tumors, with higher expression of peroxisomal matrix proteins and down regulation of certain enzymes in neoplastic samples. The degree of expression varied between tumor subtypes, suggesting peroxisomes as potential therapeutic targets or markers in certain subtypes of parotid neoplasms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
