Article
Biochemistry & Molecular Biology
Xingye Wang, Lu Ma, Songlin Zhang, Qiang Song, Xumei He, Jun Wang
Summary: This study investigates the role and molecular mechanisms of WWP2 in endothelial injury and reveals the protective effect of WWP2 against atherosclerosis progression through the PDCD4/HO-1 pathway. These findings may provide novel insights for the treatment of atherosclerosis.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Immunology
Xiaohong Fei, Xuejiang Cen, Ruochi Zhao, Jian Wang, Hanbin Cui
Summary: Atherosclerosis is the pathological basis of cardiovascular disease, which begins with endothelial dysfunction caused by vascular endothelial cell injury. PRMT5, a protein arginine methyltransferase, is highly related to cardiovascular events. This study aimed to explore the biological roles of PRMT5/PDCD4 in vascular endothelial cell injury during atherosclerosis. Results showed that PRMT5 was highly expressed in ox-LDL-stimulated HUVECs. Knockdown of PRMT5 enhanced cell viability and inhibited apoptosis, oxidative stress, inflammation, and endothelial dysfunction in HUVECs. PRMT5 was found to interact and bind with PDCD4. In conclusion, down-regulation of PRMT5 exerts protective effects against vascular endothelial cell injury during atherosclerosis by suppressing PDCD4 expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Patrick Senechal, Francis Robert, Regina Cencic, Akiko Yanagiya, Jennifer Chu, Nahum Sonenberg, Marilene Paquet, Jerry Pelletier
Summary: The translation initiation factor eIF4F is crucial for cap-dependent protein synthesis initiation. Different subunits of eIF4F have varying roles in development and tumorigenesis, with some being essential for viability and tumor onset, while others have non-essential functions. This study highlights the complex roles of different eIF4F subunits in gene expression regulation during embryogenesis and tumor development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Juan Carlos Montero, Atanasio Pandiella
Summary: Neuregulins and their ErbB/HER receptors are important in mammalian development and tissue homeostasis, with PDCD4 identified as a novel mediator in neuregulin-ErbB signaling. Phosphorylation of PDCD4 at serine 67 is shown to promote its degradation and regulate important biological functions of neuregulin, such as proliferation, migration, and invasion, through mTORC1 and ERK1/2 pathways.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Chemistry, Medicinal
Patrick D. Fischer, Evangelos Papadopoulos, Jon M. Dempersmier, Zi-Fu Wang, Radoslaw P. Nowak, Katherine A. Donovan, Joann Kalabathula, Christoph Gorgulla, Pierre P. M. Junghanns, Eihab Kabha, Nikolaos Dimitrakakis, Ognyan Petrov, Constantine Mitsiades, Christian Ducho, Vladimir Gelev, Eric S. Fischer, Gerhard Wagner, Haribabu Arthanari
Summary: The translation initiation factor eIF4E is a key regulator of cap-dependent protein synthesis, with overexpression implicated in diseases like cancer. A novel inhibitor, i4EG-BiP, has been shown to displace eIF4G and inhibit cancer cell proliferation. Efforts to design PROTACs targeting eIF4E for proteasomal degradation have faced challenges, such as competitive effects from 4E-BP1 binding.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Hong Qi, Jiancheng Zhang, You Shang, Shiying Yuan, Chunqing Meng
Summary: Argon preconditioning can inhibit the PDCD4/PTEN pathway through miR-21, reducing oxidative stress and inflammatory factor levels, protecting cardiomyocytes from MI/R injury.
Article
Oncology
Christopher A. Lucchesi, Jin Zhang, Demitria M. Vasilatis, Elizabeth Yip, Xinbin Chen
Summary: This study identifies a shortened 7-amino acid peptide (Pep7-PSAASPV) with high affinity binding to eIF4E and potent induction of p53 expression. The peptide also exhibits growth suppression effects in both human and canine osteosarcoma cells, and enhances the sensitivity of these cells to radiation therapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Zi-Chao Wang, Kai-Ming Niu, Yu-Jie Wu, Kai-Rui Du, Lian-Wen Qi, Ye-Bo Zhou, Hai-Jian Sun
Summary: This study found that Ginsenoside Rb1 can inhibit oxidative stress in endothelial cells by directly targeting Keap1 and p47(phox), which leads to the activation of Nrf2 and disruption of the NOX2 complex.
CELL DEATH & DISEASE
(2022)
Article
Environmental Sciences
Amber L. Cathey, Deborah J. Watkins, Zaira Y. Rosario, Carmen Velez, Bhramar Mukherjee, Akram N. Alshawabkeh, Jose F. Cordero, John D. Meeker
Summary: This study investigated the association between phthalate metabolite mixtures and pregnancy outcomes using a longitudinal pregnancy cohort in Puerto Rico. The results showed that exposure to phthalate mixtures was associated with increased risk of preterm birth and highlighted the importance of studying mixtures by fetal sex.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Biochemistry & Molecular Biology
Juanjuan Zhu, Hao Sun, Xinle Kang, Haixue Zhu, Xiaoteng Yan
Summary: This study verifies that acid polysaccharides from Buddleja officinalis Maxim can relieve diabetic retinopathy through inhibition of angiogenesis via activation of the Nrf2/ARE signaling pathway.
Review
Medicine, Research & Experimental
Ranmali Ranasinghe, Michael Mathai, Anthony Zulli
Summary: This review aims to provide a comprehensive collection of potential cytoprotective remedies in overcoming nephrotoxicity caused by anti-neoplastic drug metabolism and renal oxidative stress. There is an increasing need for renal replacement therapy and higher mortality rates from end-stage renal disease in the next decade, making the discussion of 43 different cytoprotective compounds crucial.
Article
Cell Biology
Yufeng Jia, Xiao Zhuang, Yi Zhang, Ming Zhao, Nuo Chen, Wen Li, Faliang Zhu, Chun Guo, Yan Li, Qun Wang, Yuan Li, Lining Zhang
Summary: Promoting BDNF expression is beneficial for depression treatment. Recent research has identified Pdcd4 as a novel target for antidepressant therapy. Delivery of RVG/siPdcd4 complex can upregulate BDNF levels and downregulate neuroinflammatory cytokine expression, offering potential as a therapeutic medicine for depression.
CELL DEATH & DISEASE
(2021)
Letter
Oncology
Tingjin Zheng, Qingbo Liu, Feiyue Xing, Chong Zeng, Weidong Wang
Summary: Disulfidptosis, a novel form of cell death caused by disulfide stress, leads to the collapse of cytoskeleton proteins and F-actin due to intracellular accumulation of disulfides. This finding holds potential for the development of therapeutic strategies against cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Mateusz Kozarski, Karolina Drazkowska, Marcelina Bednarczyk, Marcin Warminski, Jacek Jemielity, Joanna Kowalska
Summary: mRNA-based gene delivery is a powerful strategy for vaccines and therapeutics. This study synthesized novel triazole-containing tri- and tetranucleotide cap analogs through copper-catalyzed azide-alkyne cycloaddition. One of the compounds showed translational activity and biochemical properties comparable to natural cap structure, making it a promising mRNA capping reagent.
Review
Biochemistry & Molecular Biology
Alice Romagnoli, Mattia D'Agostino, Chiara Ardiccioni, Cristina Maracci, Stefano Motta, Anna La Teana, Daniele Di Marino
Summary: eIF4E plays a central role in controlling mRNA translation, with its interaction with eIF4G and 4E-BPs being crucial for the assembly of the translational machinery. Recent discoveries of non-canonical binding motifs could have implications for the development of new therapeutic strategies targeting eIF4E.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)