Article
Virology
Emily A. Bates, John R. Counsell, Sophie Alizert, Alexander T. Baker, Natalie Suff, Ashley Boyle, Angela C. Bradshaw, Simon N. Waddington, Stuart A. Nicklin, Andrew H. Baker, Alan L. Parker
Summary: Species D adenoviruses, such as human adenovirus type 49 (HAdV-D49), show promise for gene therapy applications due to their low pre-existing immunity rates. HAdV-D49 exhibits a broad range of cell transduction capabilities and interacts with various surface molecules for cell entry. Additionally, compared to adenovirus type 5, HAdV-D49 vectors demonstrate reduced liver targeting but maintain transduction of lung and spleen tissues.
Article
Medicine, Research & Experimental
Qian Zhou, Wensheng Chen, Zhenzhen Fan, Zhipeng Chen, Jinxia Liang, Guandi Zeng, Lu Liu, Wanting Liu, Tong Yang, Xin Cao, Biao Yu, Meng Xu, Ye-Guang Chen, Liang Chen
Summary: In this study, MYOCD was identified as a clinically relevant tumor suppressor gene in lung cancer patients, showing a potent inhibitory effect on lung cancer stem cells. NSCLC cells deficient of MYOCD were found to be particularly sensitive to TGFBR kinase inhibitor, and a synergistic effect was observed when combining TGFBRi with stemness inhibitor to treat MYOCD deficient lung cancers.
Article
Cell Biology
Kailing Zhou, Yu Sun, Dan Dong, Chenghai Zhao, Wei Wang
Summary: EMP3 acts as a potential tumor suppressor in breast cancer by inhibiting cell cycle progression, DNA repair, and stem-like properties, leading to enhanced sensitivity of breast cancer cells to DNA-damaging agents.
CELL DEATH & DISEASE
(2021)
Editorial Material
Hematology
Ian J. Majewski
Summary: The study investigates how loss of the tumor suppressor gene Cux1 modulates DNA repair activity in the hematopoietic compartment and contributes to the pathogenesis of therapy-related myeloid neoplasms.
Review
Cell & Tissue Engineering
Zeng Wang, Xiaozhan Zhang
Summary: Adenoviruses are common pathogens in humans and animals, causing various diseases. Despite being widely used in gene therapy, the liver tropism and side effects of AdVs leading to acute hepatotoxicity have limited their clinical application.
Review
Oncology
Sadegh Rajabi, Catherine Alix-Panabieres, Arshia Sharbatdar Alaei, Raziyeh Abooshahab, Heewa Shakib, Mohammad Reza Ashrafi
Summary: This review discusses the inactivation mechanisms and alterations of tumor-suppressor genes in thyroid cancer in order to identify more effective treatment options.
Article
Multidisciplinary Sciences
Koki Yanazawa, Takehito Sugasawa, Kai Aoki, Takuro Nakano, Yasushi Kawakami, Kazuhiro Takekoshi
Summary: This study developed a method for detecting gene doping using rAdV, which was validated through cell line experiments and mouse injections. The results suggest the potential application of this method in detecting gene doping in blood samples.
Article
Virology
Wendong Lan, Lulu Quan, Yiqiang Li, Junxian Ou, Biyan Duan, Ting Mei, Xiao Tan, Weiwei Chen, Liqiang Feng, Chengsong Wan, Wei Zhao, James Chodosh, Donald Seto, Qiwei Zhang
Summary: A novel simian adenovirus (SAdV) was isolated and used to construct gene therapy and vaccine vectors. The virus had low pre-existing neutralizing antibody levels and showed potential applications. The study also revealed the critical role of the E3 region in the virus replication in human cells.
JOURNAL OF VIROLOGY
(2023)
Review
Oncology
Xiaoxi Wang, Liping Zhong, Yongxiang Zhao
Summary: Immunogene therapy and oncolytic viruses play important roles in antitumor treatment by enhancing immune effects through genetic engineering and targeting tumor cells specifically for replication and killing, respectively. Modifying the tumor microenvironment is crucial for maximizing the efficacy of oncolytic viruses in combating malignant tumors.
Review
Pharmacology & Pharmacy
Davor Nestic, Ksenija Bozinovic, Isabela Pehar, Rebecca Wallace, Alan L. Parker, Dragomira Majhen
Summary: Adenoviruses have versatile therapeutic applications, from gene therapy to cancer treatment. Understanding the factors involved in adenovirus cell binding, entry, and trafficking, and how these factors can be manipulated to enhance the efficacy of adenovirus-based vectors, is crucial for optimizing gene therapy and vaccine development.
Article
Biotechnology & Applied Microbiology
Erwan Sallard, Lukas Schulte, Alexander van den Boom, Alexander Klimovitskii, Julius Knierer, Claudia Hagedorn, Maximilian Knocks, Wenli Zhang, Florian Kreppel, Anja Ehrhardt, Eric Ehrke-Schulz
Summary: Adenoviral vector Ad4 shows potential for gene therapy and cancer treatment. It demonstrates efficient transduction and long-lasting gene expression in cardiomyocytes and HPV-positive tumor organoids. By deleting transcription units, Ad4-based gene therapy vectors can be generated. This platform contributes to the development of improved adenoviral vectors based on non-canonical serotypes.
JOURNAL OF GENE MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Thavasyappan Thambi, Jeongmin Lee, A-Rum Yoon, Dayananda Kasala, Chae-Ok Yun
Summary: In this study, a pH- and glutathione-responsive polymer was developed to increase the transduction efficiency of adenoviruses in cancer gene therapy.
Article
Oncology
Weipu Mao, Keyi Wang, Wentao Zhang, Shuqiu Chen, Jinbo Xie, Zongtai Zheng, Xue Li, Ning Zhang, Yuanyuan Zhang, Haimin Zhang, Bo Peng, Xudong Yao, Jianping Che, Junhua Zheng, Ming Chen, Wei Li
Summary: The study found that the expression of SLERCC was downregulated in RCC and that exogenous upregulation of SLERCC could suppress the metastasis of RCC cells. Further experimental results showed that the PSPM-NPs nanotherapeutic system could effectively inhibit the growth of RCC metastases in vivo.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Chemistry, Analytical
Yong Wang, Dandan Wang, Guohua Qi, Ping Hu, Erkang Wang, Yongdong Jin
Summary: In this study, a gold nanoparticles nanomembrane-modified plasmonic glass nanopipette surface-enhanced Raman scattering (SERS) sensing platform was constructed to sensitively detect the content variation of intracellular miRNA-21. The proposed method provides a simple way to study intracellular substance change and evaluate cancer treatment outcomes.
ANALYTICAL CHEMISTRY
(2023)
Article
Cell Biology
Jesus Garcia-Banuelos, Eden Oceguera-Contreras, Ana Sandoval-Rodriguez, Blanca Estela Bastidas-Ramirez, Silvia Lucano-Landeros, Daniela Gordillo-Bastidas, Belinda C. Gomez-Meda, Arturo Santos, Eira Cerda-Reyes, Juan Armendariz-Borunda
Summary: Intramuscular delivery of an adenoviral vector containing proMMP-8 gene cDNA (AdhMMP8) is safe and effective in achieving liver fibrosis regression, reducing inflammation and profibrogenic gene expression.
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)