Article
Biochemical Research Methods
Benshen Luo, Chen Wang, Zhengyu Wang, Chuanguo Chen, Xiaozhuang Peng, Qingchun Xu
Summary: This study identified miR-216a, miR-216b, miR-217, miR-92b, miR-375, and miR-148a as new candidate biomarkers for acute pancreatitis. In vitro functional assays demonstrated that miR-92b attenuated cell injury and inflammatory responses in pancreatic cells by targeting MAP2K4.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2023)
Article
Oncology
Fuqiang Zu, Hui Chen, Qingfeng Liu, Hui Zang, Zeyu Li, Xiaodong Tan
Summary: In this study, the role of SDCBP in pancreatic cancer was investigated. High expression of SDCBP was associated with poor prognosis and promoted tumor cell proliferation, migration, and invasion through the PI3K/AKT pathway. The regulatory mechanism of SDCBP and its interaction with miR-216b were also elucidated.
FRONTIERS IN ONCOLOGY
(2022)
Article
Veterinary Sciences
Dohee Lee, Taesik Yun, Yoonhoi Koo, Yeon Chae, Minseok Choi, Byeong-Teck Kang, Mhan-Pyo Yang, Hakhyun Kim
Summary: Serum miR-216a and miR-375 are overexpressed in dogs with acute pancreatitis. In this study, the expression levels of cfa-miR-375 in the serum of dogs with acute pancreatitis were significantly different from that of healthy dogs, suggesting its potential as a biomarker for diagnosis and treatment evaluation of acute pancreatitis in dogs.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2023)
Article
Immunology
Bo Sheng, Lei Zhao, Xuefeng Zang, Jie Zhen, Yang Liu, Weishuai Bian, Wei Chen
Summary: Quercetin can alleviate inflammation in acute pancreatitis by up-regulating miR-216b, inhibiting the p38/MAPK signaling pathway, and positively affecting inflammatory mediators.
INFLAMMOPHARMACOLOGY
(2021)
Article
Cell Biology
Suheda Erener, Cara E. Ellis, Adam Ramzy, Maria M. Glavas, Shannon O'Dwyer, Sandra Pereira, Tom Wang, Janice Pang, Jennifer E. Bruin, Michael J. Riedel, Robert K. Baker, Travis D. Webber, Marina Lesina, Matthias Blu, Hana Algu, Janel L. Kopp, Stephan Herzig, Timothy J. Kieffer
Summary: miR-216a is a conserved, pancreas-specific miRNA with crucial roles in pancreatic islet and acinar cells. Deletion of miR-216a leads to reduction in islet size, beta-cell mass, and insulin levels. Induction of miR-216a increases apoptosis and decreases cell proliferation in pancreatic cells.
CELL REPORTS MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mohadeseh Fathi, Hamid Asadzadeh Aghdaie, Soudeh Ghafouri-Fard, Roshanak Shams
Summary: This study assessed the expression levels of miR-8073 and miR-642 in patients with pancreatic cancer and controls. The results showed that plasma levels of miR-8073 and miR-642 were significantly higher in pancreatic cancer patients compared to controls. miR-642 levels were inversely correlated with certain biochemical markers and positively correlated with lipase levels. Plasma levels of miR-8073 could effectively differentiate pancreatic cancer patients from controls.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Oncology
Moon Nyeo Park, Hee Won Jeon, Md Ataur Rahman, Se Sun Park, Se Yun Jeong, Ki Hyun Kim, Sung-Hoon Kim, Woojin Kim, Bonglee Kim
Summary: The study reveals the anticancer effect of dragon's blood in acute myeloid leukemia by inducing apoptosis and modulating protein expression. It also highlights the role of reactive oxygen species and miR-216b in this process.
FRONTIERS IN ONCOLOGY
(2022)
Article
Toxicology
B. Sun, Z. Qu, G. L. Cheng, Y. W. Yang, Y. F. Miao, X. G. Chen, X. B. Zhou, B. Li
Summary: The study investigated the urinary microRNA expression profile in a gentamicin-induced acute kidney injury canine model and found that miR-15b and -30a may be promising biomarkers for renal toxicity, with diagnostic values superior to traditional serum biomarkers. Furthermore, the levels of miR-15b and -30a in urine samples correlated significantly with their levels in kidney tissue samples.
TOXICOLOGY LETTERS
(2021)
Article
Toxicology
Seiichiro Kurashige, Naomi Matsutani, Toyohiko Aoki, Terutaka Kodama, Yasuteru Otagiri, Yuko Togashi
Summary: This study found that circulating miR-216a-5p and miR-217-5p could detect pancreatic damage earlier with greater magnitude in the L-arginine-induced acute pancreatitis mouse model, and their sensitivity to detect acinar cell degeneration/necrosis was superior to that of conventional pancreatic biomarkers.
JOURNAL OF TOXICOLOGICAL SCIENCES
(2023)
Article
Oncology
Linfei Huang, Lei Zhu, Sheng Pan, Jing Xu, Miao Xie, Wei Wang, Ganlin Xia
Summary: The upregulation of circ_0029803 in colorectal cancer enhances malignant behaviors of CRC cells by modulating the miR-216b-5p/SKIL axis, leading to decreased proliferation, migration, invasion, EMT, and glycolysis, and increased apoptosis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Urology & Nephrology
Sherry G. Mansour, Pavan K. Bhatraju, Steven G. Coca, Wassim Obeid, Francis P. Wilson, Ian B. Stanaway, Yaqi Jia, Heather Thiessen-Philbrook, Alan S. Go, T. Alp Ikizler, Edward D. Siew, Vernon M. Chinchilli, Chi-yuan Hsu, Amit X. Garg, W. Brian Reeves, Kathleen D. Liu, Paul L. Kimmel, James S. Kaufman, Mark M. Wurfel, Jonathan Himmelfarb, Samir M. Parikh, Chirag R. Parikh, ASSESS-AKI Consortium
Summary: A higher Angpt-1:Angpt-2 ratio is strongly associated with reduced risk of CKD progression, heart failure, and mortality in patients with AKI.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Oncology
Lei Wang, Jinxiang Wu, Naikuan Ye, Feng Li, Hanxiang Zhan, Shihong Chen, Jianwei Xu
Summary: Plasma-derived Exo-miR-19b is a promising diagnostic marker for pancreatic cancer, showing superior diagnostic value when normalized using miR-1228 in differentiating patients with Pca from healthy volunteers. The study suggests that Exo-miR-19b may be a potential alternative or supplement to serum CA19-9 for diagnosing Pca.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Shuang Zhu, Chih-Yen Chen, Yangyang Hao
Summary: This study demonstrates that KCNQ1OT1 is up-regulated in CRC tissues and cell lines, and its interference can inhibit proliferation, migration, and invasion of CRC cells. miR-216b-5p is targeted by KCNQ1OT1 in CRC cells, while ZNF146 is a target of miR-216b-5p. These findings suggest that the KCNQ1OT1/miR-216b-5p/ZNF146 axis may serve as a potential target for the diagnosis and treatment of CRC patients.
JOURNAL OF MOLECULAR HISTOLOGY
(2021)
Article
Multidisciplinary Sciences
Can Yue, Siting Xie, Jiaying Zhong, Haijun Zhao, Zhijuan Lin, Li Zhang, Bing Xu, Yiming Luo
Summary: The study found that SCAMP2/4/5 may serve as potential prognostic markers for AML, and SCAMP2 and SCAMP5 individually or in combination may be utilized as diagnostic markers for AML.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Jing Yang, Hanh Chi Do-Umehara, Qiao Zhang, Huashan Wang, Changchun Hou, Huali Dong, Edith A. Perez, Marc A. Sala, Kishore R. Anekalla, James M. Walter, Shuwen Liu, Richard G. Wunderink, G. R. Scott Budinger, Jing Liu
Summary: JNK2 plays a crucial role in regulating lung inflammation and injury during sepsis and acute lung injury. The upregulation of miR-221-5p targets JNK2 mRNA leading to downregulation of JNK2, thereby exacerbating lung inflammation and injury during sepsis.
FRONTIERS IN IMMUNOLOGY
(2021)
