期刊
BIOMEDICAL RESEARCH-TOKYO
卷 31, 期 1, 页码 53-61出版社
BIOMEDICAL RESEARCH PRESS LTD
DOI: 10.2220/biomedres.31.53
关键词
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资金
- Ministry of Education, Science, Sport, and Culture
- Ministry of Health and Labor and Welfare, Japan
- Japanese Health Sciences Foundation
- Promotion and Mutual Aid Corporation for Private School of Japan
Human T cell leukemia virus type I (HTLV-I), a causative agent of adult T-cell leukemia (ATL), is transmitted from mother to child predominantly by breastfeeding. The source of HTLV-I-infected cells in breast milk has been thought to be T cells, however, the majority of cells in breast milk are CD14(+) macrophages but not CD3(+) T lymphocytes, and no data are available regarding HTLV-I transmission through breast milk macrophages (BrMM Phi). To explore the potential of BrMM Phi as a possible source of infection in mother to child transmission (MTCT) of HTLV-I, an immortalized cell line (HTLV-BrMM Phi) has been established from BrMM Phi by infection with HTLV-I. HTLV-BrMM Phi retained macrophage characteristics and did not express a complete dendritic cell (DC) phenotype; nevertheless, HTLV-BrMM Phi efficiently promoted T cell proliferation in primary allogeneic mixed lymphocyte reaction (MLR) like DC. Moreover, HTLV-I infection could be transmitted from HTLV-BrMM Phi to activated T cells in the peripheral blood. These findings suggested that BrMM Phi might be an appropriate HTLV-I reservoir involved in MTCT transmission via breastfeeding.
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