APPL endosomes are not obligatory endocytic intermediates but act as stable cargo-sorting compartments

ESCRT-0 marks an APPL1-independent transit route for EGFR between the cell surface and the EEA1-positive early endosome

(2015) N. Flores-Rodriguez et al.   JOURNAL OF CELL SCIENCE

Mammalian CORVET Is Required for Fusion and Conversion of Distinct Early Endosome Subpopulations

(2014) Enrico D. Perini et al.   TRAFFIC

Endocytosis, Signaling, and Beyond

(2014) P. P. Di Fiore et al.   Cold Spring Harbor Perspectives in Biology

Rab GTPase regulation of membrane identity

(2013) Suzanne R Pfeffer   CURRENT OPINION IN CELL BIOLOGY

SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome

(2013) C. Danson et al.   JOURNAL OF CELL SCIENCE

Using multifocal plane microscopy to reveal novel trafficking processes in the recycling pathway

(2013) Z. Gan et al.   JOURNAL OF CELL SCIENCE

A General Theoretical Framework to Infer Endosomal Network Dynamics from Quantitative Image Analysis

(2012) Lionel Foret et al.   CURRENT BIOLOGY

APPL1 regulates basal NF-κB activity by stabilizing NIK

(2012) Anna Hupalowska et al.   JOURNAL OF CELL SCIENCE

Adaptor Protein APPL1 Couples Synaptic NMDA Receptor with Neuronal Prosurvival Phosphatidylinositol 3-Kinase/Akt Pathway

(2012) Y.-b. Wang et al.   JOURNAL OF NEUROSCIENCE

Rab5 is necessary for the biogenesis of the endolysosomal system in vivo

(2012) Anja Zeigerer et al.   NATURE

The PDZ Protein GIPC Regulates Trafficking of the LPA1 Receptor from APPL Signaling Endosomes and Attenuates the Cell’s Response to LPA

(2012) Tal Varsano et al.   PLoS One

APPL1 potentiates insulin secretion in pancreatic   cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice

(2012) K. K. Y. Cheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis

(2012) D. M. Navaroli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics of Intracellular Clathrin/AP1- and Clathrin/AP3-Containing Carriers

(2012) Comert Kural et al.   Cell Reports

Macropinocytosis: an endocytic pathway for internalising large gulps

(2011) Jet Phey Lim et al.   IMMUNOLOGY AND CELL BIOLOGY

An APPL1/Akt signaling complex regulates dendritic spine and synapse formation in hippocampal neurons

(2011) Devi Majumdar et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

APPL1 mediates adiponectin-stimulated p38 MAPK activation by scaffolding the TAK1-MKK3-p38 MAPK pathway

(2010) Xiaoban Xin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Identification of the Switch in Early-to-Late Endosome Transition

(2010) Dmitry Poteryaev et al.   CELL

Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells

(2010) Mark T. Howes et al.   JOURNAL OF CELL BIOLOGY

Systems survey of endocytosis by multiparametric image analysis

(2010) Claudio Collinet et al.   NATURE

Mechanisms of Endocytosis

(2009) Gary J. Doherty et al.   Annual Review of Biochemistry

A Phosphoinositide Switch Controls the Maturation and Signaling Properties of APPL Endosomes

(2009) Roberto Zoncu et al.   CELL

Endosomal Adaptor Proteins APPL1 and APPL2 Are Novel Activators of β-Catenin/TCF-mediated Transcription

(2009) Sajid Rashid et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes

(2009) Takeshi Ohya et al.   NATURE

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Endocytosis and signalling: intertwining molecular networks

(2009) Alexander Sorkin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Distinct Dynamics of Endocytic Clathrin-Coated Pits and Coated Plaques

(2009) Saveez Saffarian et al.   PLOS BIOLOGY

APPL1: role in adiponectin signaling and beyond

(2008) Sathyaseelan S. Deepa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The Endosomal Protein Appl1 Mediates Akt Substrate Specificity and Cell Survival in Vertebrate Development

(2008) Annette Schenck et al.   CELL

Clathrin-Mediated Internalization Is Essential for Sustained EGFR Signaling but Dispensable for Degradation

(2008) Sara Sigismund et al.   DEVELOPMENTAL CELL

Signaling from endosomes: Location makes a difference

(2008) Lukasz Sadowski et al.   EXPERIMENTAL CELL RESEARCH

Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes

(2008) D. Leonard et al.   JOURNAL OF CELL SCIENCE