Review
Biochemistry & Molecular Biology
Marianna Makowska, Beata Smolarz, Hanna Romanowicz
Summary: Glioblastoma multiforme (GBM) is a common, malignant brain tumor with a poor prognosis. Traditional treatments have limited success due to the tumor's infiltrating growth and resistance. The search for new therapies is crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Materials Science, Biomaterials
Yixiao Cui, Paul Lee, Jesse J. Reardon, Anna Wang, Skylar Lynch, Jose J. Otero, Gina Sizemore, Jessica O. Winter
Summary: Researchers used a 3D collagen I-hyaluronic acid hydrogel material to study the interaction between glioblastoma cells and astrocytes. They observed different migration behaviors and found differential gene expression in immune response, inflammation, and cytokine signaling.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Oncology
Satya Siva Kishan Yalamarty, Nina Filipczak, Xiang Li, Md Abdus Subhan, Farzana Parveen, Janaina Artem Ataide, Bharat Ashok Rajmalani, Vladimir P. Torchilin
Summary: Glioblastoma multiforme (GBM) is a highly aggressive form of brain cancer that is difficult to treat due to its resistance to traditional cancer treatments. The unique biology of GBM cells and the blood-brain barrier contribute to this resistance. However, there are several treatment options available, including surgery, chemoradiotherapy, adjuvant chemotherapy, immunotherapy, targeted therapies, and tumor-treating fields. Ongoing clinical trials aim to improve outcomes for GBM patients.
Article
Biochemistry & Molecular Biology
Youngik Yoon, Chae Rin Yoo, Eun Chae Kim, Jaehwan Han, Keejung Yoon
Summary: This study investigates the role of the gene STAC1 in glioblastoma cell invasion and survival. It is found that STAC1 overexpression promotes invasion and inhibits apoptosis, while knockdown of STAC1 has the opposite effect. The study also reveals that STAC1 regulates AKT and calcium channel signaling in glioblastoma cells. These findings provide valuable insights into the pathogenic roles of STAC1 in high-grade glioblastoma and highlight its potential as a promising therapeutic target.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Yi-Ping Huang, Yi-Shih Ma, Chao-Lin Kuo, Ching-Lung Liao, Po-Yuan Chen, Shu-Fen Peng, Fei-Ting Hsu, Kuang-Chi Lai
Summary: In a mouse model experiment, DMC was found to significantly suppress human glioblastoma multiforme cells, with a better effect at a higher dose, while not affecting body weight. Additionally, DMC treatment had an impact on the expression of tumor-related proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Xingliang Dai, Lei Ye, Huaixu Li, Xuchen Dong, Haotian Tian, Peng Gao, Jun Dong, Hongwei Cheng
Summary: Single-cell whole-transcriptome sequencing revealed interactions between putative NSCs and microglial cells in the peri-tumoral tissue of glioblastoma multiforme. Ligand receptor network analysis showed significant interactions between APOC1+CCL3+ microglia and NSCs. Correlation analysis with potential molecular targets demonstrated their roles in the recurrence of GBM.
CLINICAL IMMUNOLOGY
(2023)
Article
Oncology
Rehab G. Amer, Lobna R. Ezz El Arab, Dalia Abd El Ghany, Amr S. Saad, Nermean Bahie-Eldin, Menha Swellam
Summary: In this study, the clinical role of lncRNA565 and lncRNA641 in GBM patients was investigated. The results showed that the expressions of these two long non-coding RNAs were significantly increased in GBM patients and were correlated with clinico-pathological data and survival pattern. Additionally, higher levels of these lncRNAs were associated with worse disease progression and overall survival. Therefore, the expression of lncRNA565 and lncRNA641 can serve as prognostic biomarkers for GBM patients.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Oncology
Mengying Wang, Binghong Chen, Wenrui Zhang, Fengchen Zhang, Yongming Qiu, Yingying Lin, Shaofeng Yang
Summary: The overexpression of dematin actin-binding protein (DMTN) has been found to inhibit the proliferation and invasion of glioblastoma multiforme (GBM) by affecting cell cycle regulation and actin remodeling. In addition, DMTN expression was significantly reduced in high-grade gliomas and correlated with worse survival in patients.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Julia Penas-Martinez, Gines Luengo-Gil, Salvador Espin, Nataliya Bohdan, Carmen Ortega-Sabater, Maria Carmen Rodenas, David Zaragoza-Huesca, Maria Jose Lopez-Andreo, Carme Plasencia, Vicente Vicente, Alberto Carmona-Bayonas, Irene Martinez-Martinez
Summary: Our study reveals the versatile anti-tumor properties of prelatent antithrombin on U-87 MG glioblastoma multiforme cells, inhibiting migration and invasion while having a lesser effect on proliferation. Prelatent antithrombin down-regulated the expression of VEGFA, pSTAT3, and pERK1/2 in U-87 MG cells.
Article
Clinical Neurology
Yiran Wei, Chao Li, Zaixu Cui, Roxanne Claudeve Mayrand, Jingjing Zou, Adrianna Leanne Kok Chi Wong, Rohitashwa Sinha, Tomasz Matys, Carola-Bibiane Schoenlieb, Stephen John Price
Summary: Wei et al. investigate the topological changes in the connectome of glioblastoma patients, revealing widespread distant disruptions that are not visible on conventional MRI. These disruptions are associated with impaired cognition and survival, providing prognostic value in glioblastoma patients.
Article
Medicine, Research & Experimental
Mahban Rahimifard, Zeinab Bagheri, Mahmoudreza Hadjighassem, Razieh Pourahmad Jaktaji, Ebrahim Behroodi, Hamed Haghi-Aminjan, Mahsa Azami Movahed, Hamid Latifi, Saereh Hosseindoost, Afshin Zarghi, Jalal Pourahmad
Summary: This study demonstrates that the new pyrazino[1,2-a]benzimidazole derivatives L1 and L2 can reduce the invasion of GBM cells by controlling the expression of genes related to migration and proliferation. Additionally, the design of a microfluidic platform and related cell culture protocols facilitate the broad screening of 3D multicellular tumor spheroids derived from GBM tumor biopsies and provide effective support for drug development for brain gliomas.
Review
Pharmacology & Pharmacy
Kanawat Wiwatchaitawee, Juliana C. Quarterman, Sean M. Geary, Aliasger K. Salem
Summary: Glioblastoma multiforme (GBM) is an aggressive brain tumor, with current treatments including surgery, radiation, and chemotherapy, while nanoparticle-mediated delivery systems show promise. Drug delivery via nanoparticles can reduce toxicity, increase specificity, and improve survival and quality of life for GBM patients.
Article
Oncology
Bin Jia, Xu Zheng, Mo-Li Wu, Xiao-Ting Tian, Xue Song, Yan-Na Liu, Pei-Nan Li, Jia Liu
Summary: The study found that resveratrol's effects on glioblastoma cells are closely related to oxidative stress and mitochondrial function. By activating the ROS-related mitochondrial signal pathway, resveratrol increased ROS production and induced oxidative damage in U251 cells, leading to apoptosis.
Article
Oncology
Ruei-Yu Su, Shu-Ching Hsueh, Cheng-Yen Chen, Ming-Jie Hsu, Hsu-Feng Lu, Shu-Fen Peng, Po-Yuan Chen, Jin-Cherng Lien, Yung-Liang Chen, Fu-Shin Chueh, Jing-Gung Chung, Ming-Yang Yeh, Yi-Ping Huang
Summary: DMC has shown significant inhibitory effect on the proliferation of human glioblastoma cancer cells, with the internalized amount reaching the highest level after 3 hours of treatment.
ANTICANCER RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Puja Sandbhor, Jayant S. Goda, Bhabani Mohanty, Pradip Chaudhari, Shilpee Dutt, Rinti Banerjee
Summary: A minimally invasive hydrogel implant has been developed for the treatment of glioblastoma, using transferrin-targeted nanovesicles in the surgically resected tumor cavity. The controlled release of drugs from the hydrogel system improves drug penetration and enhances the efficacy of adjuvant therapy.
Review
Genetics & Heredity
Chengqi Xin, Chun Wang, Yachen Wang, Jingyuan Zhao, Liang Wang, Runjie Li, Jing Liu
BMC MEDICAL GENETICS
(2018)
Article
Biochemistry & Molecular Biology
Liang Wang, Ying Li, Xin Guan, Jingyuan Zhao, Liming Shen, Jing Liu
Article
Oncology
Chao Qu, Jingyun Ma, Yejun Zhang, Chao Han, Liang Huang, Liming Shen, Hongyan Li, Xiaobo Wang, Jing Liu, Wei Zou
Article
Cell & Tissue Engineering
Yang Jiao, Xiao-yan Li, Jing Liu
CELL TRANSPLANTATION
(2019)
Article
Cell Biology
Jia Wang, Yanhong Ma, Jingshi Yang, Lu Jin, Zixiang Gao, Lingyun Xue, Lin Hou, Linlin Sui, Jing Liu, Xiangyang Zou
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2019)
Review
Cell & Tissue Engineering
Jiayi Wang, Wei Zou, Jingyun Ma, Jing Liu
STEM CELLS AND DEVELOPMENT
(2019)
Review
Cell Biology
Yang Jiao, Yu-Wan Liu, Wei-Gong Chen, Jing Liu
Summary: Stroke is a leading cause of death and disability worldwide. Stem cell-based interventions, particularly neural stem cells, show promise in substantial recovery of brain function after stroke. Neural stem cells play a crucial role in neurological repair, offering unique advantages in cell replacement, paracrine action, inflammatory regulation, and neuroprotection.
NEURAL REGENERATION RESEARCH
(2021)
Article
Medical Laboratory Technology
Min Feng, JingYuan Zhao, Liang Wang, Jing Liu
ANNALS OF CLINICAL AND LABORATORY SCIENCE
(2018)
Article
Nanoscience & Nanotechnology
Li-Ming Shen, Linglai Quan, Jing Liu
ACS APPLIED NANO MATERIALS
(2018)