Dense fibrillar collagen is a potent inducer of invadopodia via a specific signaling network

SNAP23, Syntaxin4, and vesicle-associated membrane protein 7 (VAMP7) mediate trafficking of membrane type 1–matrix metalloproteinase (MT1-MMP) during invadopodium formation and tumor cell invasion

(2014) Karla C. Williams et al.   MOLECULAR BIOLOGY OF THE CELL

Stromal Fibroblasts Mediate Extracellular Matrix Remodeling and Invasion of Scirrhous Gastric Carcinoma Cells

(2014) Hideki Yamaguchi et al.   PLoS One

Megakaryocytes assemble podosomes that degrade matrix and protrude through basement membrane

(2013) H. Schachtner et al.   BLOOD

Tks5 and SHIP2 Regulate Invadopodium Maturation, but Not Initiation, in Breast Carcinoma Cells

(2013) Ved P. Sharma et al.   CURRENT BIOLOGY

Vav1 as a Central Regulator of Invadopodia Assembly

(2013) Gina L. Razidlo et al.   CURRENT BIOLOGY

MT1-MMP-Dependent Control of Skeletal Stem Cell Commitment via a β1-Integrin/YAP/TAZ Signaling Axis

(2013) Yi Tang et al.   DEVELOPMENTAL CELL

The dual role of filamin A in cancer: can't live with (too much of) it, can't live without it

(2013) Rosalinda M Savoy et al.   ENDOCRINE-RELATED CANCER

Calcium and Calmodulin-dependent Serine/Threonine Protein Kinase Type II (CaMKII)-mediated Intramolecular Opening of Integrin Cytoplasmic Domain-associated Protein-1 (ICAP-1α) Negatively Regulates β1 Integrins

(2013) Angélique Millon-Frémillon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia

(2013) Pedro Monteiro et al.   JOURNAL OF CELL BIOLOGY

β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation

(2013) Brian T. Beaty et al.   MOLECULAR BIOLOGY OF THE CELL

β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

(2013) Herbert B. Schiller et al.   NATURE CELL BIOLOGY

Oncogenic targeting of BRM drives malignancy through C/EBPβ-dependent induction of α5 integrin

(2013) L Damiano et al.   ONCOGENE

Kindlin-2 Expression in Peritumoral Stroma Is Associated With Poor Prognosis in Pancreatic Ductal Adenocarcinoma

(2013) Prawej Mahawithitwong et al.   PANCREAS

Increased expression of putative cancer stem cell markers in the bone marrow of prostate cancer patients is associated with bone metastasis progression

(2013) Estelle Ricci et al.   PROSTATE

Integrin alpha2beta1 (α2β1) promotes prostate cancer skeletal metastasis

(2012) Joseph L. Sottnik et al.   CLINICAL & EXPERIMENTAL METASTASIS

Nonpolarized signaling reveals two distinct modes of 3D cell migration

(2012) Ryan J. Petrie et al.   JOURNAL OF CELL BIOLOGY

N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors

(2012) B. Gligorijevic et al.   JOURNAL OF CELL SCIENCE

Why the stroma matters in breast cancer

(2012) Matthew W. Conklin et al.   Cell Adhesion & Migration

Kindlin-2: a novel adhesion protein related to tumor invasion, lymph node metastasis, and patient outcome in gastric cancer

(2011) Zhanlong Shen et al.   AMERICAN JOURNAL OF SURGERY

Degrading Devices: Invadosomes in Proteolytic Cell Invasion

(2011) Stefan Linder et al.   Annual Review of Cell and Developmental Biology

Regulation of Integrin Activation

(2011) Chungho Kim et al.   Annual Review of Cell and Developmental Biology

Biochemical role of the collagen-rich tumour microenvironment in pancreatic cancer progression

(2011) Mario A. Shields et al.   BIOCHEMICAL JOURNAL

Sensing and Modulation of Invadopodia across a Wide Range of Rigidities

(2011) Aron Parekh et al.   BIOPHYSICAL JOURNAL

A Novel Spatiotemporal RhoC Activation Pathway Locally Regulates Cofilin Activity at Invadopodia

(2011) Jose Javier Bravo-Cordero et al.   CURRENT BIOLOGY

Remodeling and homeostasis of the extracellular matrix: implications for fibrotic diseases and cancer

(2011) T. R. Cox et al.   Disease Models & Mechanisms

Kindlin-3–mediated signaling from multiple integrin classes is required for osteoclast-mediated bone resorption

(2011) Sarah Schmidt et al.   JOURNAL OF CELL BIOLOGY

Adhesion dynamics at a glance

(2011) M. Vicente-Manzanares et al.   JOURNAL OF CELL SCIENCE

Cdc42-interacting protein 4 is a Src substrate that regulates invadopodia and invasiveness of breast tumors by promoting MT1-MMP endocytosis

(2011) J. Hu et al.   JOURNAL OF CELL SCIENCE

Talin-1 overexpression defines high risk for aggressive oral squamous cell carcinoma and promotes cancer metastasis

(2011) Ming-Tsung Lai et al.   JOURNAL OF PATHOLOGY

Physiological type I collagen organization induces the formation of a novel class of linear invadosomes

(2011) Amélie Juin et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of the α2β1 Integrin Alters Human Papilloma Virus-Induced Squamous Carcinoma Progression In Vivo and In Vitro

(2011) Thuy Tran et al.   PLoS One

System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation

(2011) K. T. G. Rigbolt et al.   Science Signaling

Dynamic reciprocity in the wound microenvironment

(2011) Gregory S. Schultz et al.   WOUND REPAIR AND REGENERATION

The Actin-Bundling Protein Fascin Stabilizes Actin in Invadopodia and Potentiates Protrusive Invasion

(2010) Ang Li et al.   CURRENT BIOLOGY

Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia

(2010) Marie Schoumacher et al.   JOURNAL OF CELL BIOLOGY

Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia

(2010) M. Oser et al.   JOURNAL OF CELL SCIENCE

The α2β1 integrin is a metastasis suppressor in mouse models and human cancer

(2010) Norma E. Ramirez et al.   JOURNAL OF CLINICAL INVESTIGATION

A Role for Fibrillar Collagen Deposition and the Collagen Internalization Receptor Endo180 in Glioma Invasion

(2010) Ivo J. Huijbers et al.   PLoS One

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Spatial and temporal activation of the small GTPases RhoA and Rac1 by the netrin-1 receptor UNC5a during neurite outgrowth

(2009) Mariêve Picard et al.   CELLULAR SIGNALLING

Talin 2 is a large and complex gene encoding multiple transcripts and protein isoforms

(2009) Emmanuel Debrand et al.   FEBS Journal

The role of kindlins in cell biology and relevance to human disease

(2009) J.E. Lai-Cheong et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Plasticity of cell migration: a multiscale tuning model

(2009) Peter Friedl et al.   JOURNAL OF CELL BIOLOGY

The Extracellular Matrix: Not Just Pretty Fibrils

(2009) R. O. Hynes   SCIENCE

Tks5-Dependent, Nox-Mediated Generation of Reactive Oxygen Species Is Necessary for Invadopodia Formation

(2009) B. Diaz et al.   Science Signaling

Quantitative Phosphoproteomic Analysis of T Cell Receptor Signaling Reveals System-Wide Modulation of Protein-Protein Interactions

(2009) V. Mayya et al.   Science Signaling

Proteomic Analysis of Integrin-Associated Complexes Identifies RCC2 as a Dual Regulator of Rac1 and Arf6

(2009) J. D. Humphries et al.   Science Signaling

The Kindlin protein family: new members to the club of focal adhesion proteins

(2009) Alexander Meves et al.   TRENDS IN CELL BIOLOGY

Collagen density promotes mammary tumor initiation and progression

(2008) Paolo P Provenzano et al.   BMC Medicine

Extracellular Matrix Rigidity Promotes Invadopodia Activity

(2008) Nelson R. Alexander et al.   CURRENT BIOLOGY

Kindlins: essential regulators of integrin signalling and cell–matrix adhesion

(2008) Hannu Larjava et al.   EMBO REPORTS

Integrins in prostate cancer progression

(2008) H. L. Goel et al.   ENDOCRINE-RELATED CANCER

p190B RhoGAP regulates endothelial-cell-associated proteolysis through MT1-MMP and MMP2

(2008) F. Guegan et al.   JOURNAL OF CELL SCIENCE