Review
Polymer Science
Lei Chen, Zhiyong Zeng, Wenbing Li
Summary: This review discusses the function and mechanism of poly(acrylic acid) (PAA) in regulating the mineralization of collagen, particularly intrafibrillar mineralization (IM). The differences between two mineralization patterns (extrafibrillar and intrafibrillar) in terms of microstructure, biodegradation, cytocompatibility, osteoinduction in vitro, and performance in vivo are systematically compared. The review also includes the mineralization of self-mineralizable collagen matrices and references regarding collagen/PAA interactions in other fields. Finally, future potential improvements in this field are discussed.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Materials Science, Ceramics
Shuaishuai Li, Ren Guo, Song Chen, Jianan Zhang, Toshiyuki Ikoma, Xiaona Li, Weiyi Chen
Summary: In this study, porous hollow hydroxyapatite (HAp) microspheres were successfully prepared using chitosan microspheres as sacrificial templates. The microstructure, biocompatibility, and drug delivery properties of HAp microspheres were evaluated. The results showed that the HAp microspheres had a spherical morphology with a porous and core-shell structure. They exhibited good biocompatibility and could support the attachment and proliferation of osteoblast cells. Furthermore, the HAp microspheres could adsorb and deliver a model drug, tetracycline hydrochloride (TH), and retain its biological activity to inhibit the growth of bacteria.
INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hao Tan, Soo-Young Park
Summary: Monodispersed cross-linked poly(acrylic acid) droplets prepared with microfluidic method can be used as sensors to detect both Ca2+ and Mg2+ in saliva and serum, with the droplets shrinking in response to the presence of divalent metal ions. The size reduction speed of the droplets is correlated with the concentration of the divalent metal ion, allowing for accurate calculation of the metal ion concentrations in a mixture solution.
Article
Instruments & Instrumentation
Rasha R. Radwan, Hussein E. Ali
Summary: The study investigated the use of chitosan/poly(acrylic acid) nanogel to improve the bioavailability and anticancer potential of rutin. The prepared nanogels were characterized and used as a nano-drug carrier for rutin, showing enhanced anti-proliferative, anti-angiogenic, and apoptotic effects compared to free rutin. This formulation could be a promising agent for the treatment of hepatocellular carcinoma.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Article
Materials Science, Ceramics
Youqu Shen, Julie A. Semon, Richard K. Brow
Summary: Hollow biphasic calcium phosphate (BCP) microspheres with different fractions of nanocrystalline hydroxyapatite (HA) and beta-tricalcium phosphate (beta-TCP) were prepared and evaluated for their in vitro and in vivo reactivity. The microspheres showed varying degrees of calcium ion release and bone formation, with greater fractions of beta-TCP promoting more new bone formation.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Demiana H. Hanna, Amira A. Hamed, Gamal R. Saad
Summary: A novel method was developed to intercalate methotrexate in poly(3-hydroxybutyrate)/chitosan-graft poly (acrylic acid) conjugated with sodium hyaluronate for targeted delivery of the anti-cancer medication. The system showed high drug loading efficiency, sustained release, and effectively induced cytotoxicity and apoptosis in colon cancer cell lines.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Materials Science, Biomaterials
Jianhua Zhang, Junfei Hu, Baoshu Chen, Tianbao Zhao, Zhipeng Gu
Summary: The PAA/PEA hybrid hydrogel dressing exhibits good antioxidant properties which can promote wound healing, support cell proliferation, and angiogenesis. Experimental results on mouse skin wounds demonstrate that the hybrid hydrogel scaffolds significantly accelerate the wound healing process, showing superior healing effects.
REGENERATIVE BIOMATERIALS
(2021)
Article
Polymer Science
Stephanie M. Barbon, Matthew C. D. Carter, Ligeng Yin, C. Matthew Whaley, Vurtice C. Albright, Ron E. Tecklenburg
Summary: This study investigates the biodegradability of poly(acrylic acid) (PAA) with different molecular weights. The results show that high molecular weight PAA has poor biodegradability, while low molecular weight PAA has better biodegradability. These findings contribute to understanding the degradation mechanisms of linear PAA and inspire the design of biodegradable PAA-containing materials.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Qianyu Sun, Tianzhong Yuan, Gang Yang, Daliang Guo, Lizheng Sha, Rendang Yang
Summary: In this study, sustained-release composite microspheres containing curcumin-loaded cyclodextrin metal-organic frameworks (CD-MOFs-Cur) were successfully prepared using a solid-in-oil-in-oil (s/o/o) emulsifying solvent evaporation method. These composite microspheres exhibited different degradation rates and curcumin release rates, and showed favorable cytocompatibility.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Xiyuan Yi, Yong Luo, Qi Zhou, Jun Wang, Zengtao Yang
Summary: Insulin therapy is the most effective way to control blood glucose in diabetic patients, and subcutaneous injection is the most effective administration route. Chitosan poly-acrylic acid nanobubbles were developed as drug carriers for insulin, achieving visually controlled pulsatile release triggered by focused ultrasound. The release of insulin from nanobubbles could be accurately controlled under ultrasound guidance, significantly reducing the injection frequency of insulin.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Physical
Mehmet Topuz
Summary: In this research, a hydroxyapatite-Al2O3 reinforced poly (lactic acid) hybrid coating was synthesized on magnesium to improve interface strength, corrosion properties, and dissolution rate. The coatings were produced using the spin-coating technique of the synthesized solutions. The characterization, mechanical properties, and in-vitro bioactivity of the hybrid coatings were investigated.
SURFACES AND INTERFACES
(2023)
Article
Chemistry, Applied
Nashiely A. Rodriguez-Loredo, Victor M. Ovando-Medina, Elias Perez, Miguel A. Corona-Rivera, Elsa Cervantes-Gonzalez, Iveth D. Antonio-Carmona, Claudia J. Ramos-Torres
Summary: Studies have shown that smart hydrogels can be used for controlled drug delivery controlled by external stimuli. In this study, a composite hydrogel of PAAc/LS/Chit was developed for the adsorption and release of ketorolac. The hydrogel exhibited pH-dependent pore sizes, with smaller pores at acidic pH and larger pores at pH = 9. The swelling and water absorption of the hydrogel increased with the pH of the medium, and the release of ketorolac followed the Korsmeyer-Peppas mathematical model.
JOURNAL OF VINYL & ADDITIVE TECHNOLOGY
(2023)
Article
Polymer Science
Yi-Cheng Huang, Yang-Jie Zeng, Yu-Wei Lin, Hung-Chih Tai, Trong-Ming Don
Summary: A dual pH/thermo-responsive block copolymer was synthesized and used to encapsulate the anticancer drug CPT. The drug carrier showed stable particle size and charge, good biocompatibility with cells, and controlled release and cellular uptake of CPT based on environmental conditions. It exhibited high cytotoxicity against H460 cancer cells, suggesting its potential application in oral administration.
Article
Materials Science, Composites
Lirui Shen, Honghong Bu, Yuanzhi Zhang, Pingping Tang, Guoying Li
Summary: In this study, a polymer-mediated co-organization strategy was employed to achieve homogeneous mineralization, which is crucial for synthesizing collagen-hydroxyapatite (HAP) composites resembling natural bone. The results showed that the concentration and molecular weight of PAA have significant effects on the stability of ACP precursors and collagen mineralization outcomes.
POLYMER COMPOSITES
(2021)
Article
Biochemistry & Molecular Biology
Ebtesam M. Al Shanqiti, Khalid O. Alfooty, Magdy Y. Abdelaal
Summary: The thermal analysis of modified chitosan (CS) showed improved thermal stability compared to unmodified CS, with the addition of hydroxyapatite (HA) and multiwalled carbon nanotubes (MWCNT) enhancing this stability. Furthermore, the modified CS exhibited increased metal ion uptake and controlled release of the antitumor drug 5-fluorouracil (FU) in aqueous media.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
