Article
Materials Science, Ceramics
Reece N. Oosterbeek, Kalliope Margaronis, Xiang C. Zhang, Serena M. Best, Ruth E. Cameron
Summary: Phosphate glasses for bioresorbable implants exhibit varying dissolution rates based on composition, with a proposed new mechanism involving a two-stage dissolution process influenced by lower Ca concentration and solution pH. This new mechanism suggests an initial diffusion-controlled formation of a conversion layer, followed by rate-limiting layer dissolution reactions once the layer is stabilized. These findings provide insight into the dissolution mechanisms of P2O5-CaO-Na2O glass, particularly regarding the transition between the two dissolution stages.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Matej Par, Andrea Gubler, Thomas Attin, Zrinka Tarle, Andro Tarle, Tobias T. Tauboeck
Summary: The experimental composites containing bioactive glass and selected commercial materials demonstrated the potential for releasing multiple ion types and increasing pH, which is clinically significant for preventing demineralization and promoting remineralization.
JOURNAL OF DENTISTRY
(2022)
Article
Engineering, Multidisciplinary
Ming-Hsien Hu, Pei-Yi Chu, Ssu-Meng Huang, Bo-Sin Shih, Chia-Ling Ko, Jin-Jia Hu, Wen-Cheng Chen
Summary: The composite bone cement of calcium phosphate cement (CPC) and mesoporous bioactive glass (MBG) shows potential advantages in clinical applications, with good injectability and disintegration resistance. However, increasing the MBG content decreases the working/setting time and compressive strength.
Article
Materials Science, Ceramics
H. Mabroum, H. Noukrati, H. Ben Youcef, B. Lefeuvre, H. Oudadesse, A. Barroug
Summary: Novel composite cement based on CPC, BG, and Alg shows advantages in setting time and rheological properties, with improved mechanical performance by adding BG and Alg, which may have potential clinical applications.
CERAMICS INTERNATIONAL
(2021)
Article
Engineering, Biomedical
Richard Frank Richter, Corina Vater, Margarete Korn, Tilman Ahlfeld, Martina Rauner, Winnie Pradel, Bernd Stadlinger, Michael Gelinsky, Anja Lode, Paula Korn
Summary: Calcium phosphate cements (CPC) are bone replacement materials with good bioactivity, but slow degradation. By combining CPC with mesoporous bioactive glass (MBG) particles, degradation can be enhanced. Functionalizing the MBG with hypoxia conditioned medium (HCM) can support new bone formation. This highly flexible material system has potential for clinical translation.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Physical
Arief Cahyanto, Michella Liemidia, Elin Karlina, Myrna Nurlatifah Zakaria, Khairul Anuar Shariff, Cortino Sukotjo, Ahmed El-Ghannam
Summary: The study investigated the effect of silica calcium phosphate composites (Si-CaP) and calcium hydroxide (Ca(OH)2) on the mechanical and biological properties of carbonate apatite (CO(3)Ap) cement. It was found that adding 3% Si-CaP and 7% Ca(OH)2 resulted in the highest compressive strength. Soaking the cement in simulated body fluid (SBF) showed the formation of apatite layer and an increase in Ca, P, and Si elements. This combination of additives improved the compressive strength and demonstrated good bioactivity, making CO(3)Ap cement a potential biomaterial for bone and dental engineering applications.
Article
Biophysics
Ahmed El-Fiqi, Joong-Hyun Kim, Hae-Won Kim
Summary: The study successfully prepared highly bioactive bone cement microspheres, which have the potential to serve as bone defect fillers to promote bone regeneration. These microspheres have a large specific surface area, sustained release of soluble silicate ions, and high protein adsorption capacity. The experimental results demonstrate that these cement microspheres exhibit excellent bioactivity both in vitro and in vivo, accelerating new bone formation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Engineering, Biomedical
Richard Frank Richter, Tilman Ahlfeld, Michael Gelinsky, Anja Lode
Summary: This study investigates the composite materials of calcium phosphate cements (CPC)-mesoporous bioactive glasses (MBG) and demonstrates that the degradation of the final scaffolds can be influenced by varying the MBG content. Additionally, therapeutic ions can be incorporated into the cement phase or the MBG to vary the released ion concentration. The high specific surface area of MBG allows for the functionalization of proteins without impairing the extrudability of the CPC-MBG composites. Moreover, the released proteins from these composites maintain their biological activity, making the CPC-MBG system a promising candidate for bone tissue engineering.
ACTA BIOMATERIALIA
(2023)
Article
Materials Science, Ceramics
Hanaa Mabroum, Hassan Noukrati, Hicham Ben Youcef, Hassane Oudadesse, Allal Barroug
Summary: This study investigates the effect of particle size of bioactive glass on the properties of carbonated apatite cement. The results show that the particle size and liquid phase have a significant impact on the setting, rheological, and mechanical properties of the cement. The optimal formulation includes coarse particles and Alg-NaP as the liquid phase.
CERAMICS INTERNATIONAL
(2022)
Review
Engineering, Biomedical
Oznur Demir-Oguz, Aldo R. Boccaccini, Dagnija Loca
Summary: Calcium phosphate bone cements (CPCs) have valuable properties such as bioactivity, osteoconductivity, injectability, and moldability, but their low mechanical performance limits their clinical application. Adding bioactive glasses (BGs) as a secondary powder phase can improve the injectable properties of CPCs and enhance the degradation rate, in vitro osteogenic differentiation, cell response, and tissue-material interaction.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Medicinal
Shih-Ming Liu, Jian-Chih Chen, Ssu-Meng Huang, Shang-Hong Lin, Wen-Cheng Chen
Summary: This study compares the performance of anti-osteoporotic drugs ALN and FA impregnated into nanoparticles of mesoporous bioactive glass (nMBG) composites with calcium phosphate cement (CPC). The drug release, physicochemical properties, and biocompatibility of the nMBG@CPC composite bone cement are tested, as well as the effect on the proliferation and differentiation efficiency of mouse precursor osteoblasts (D1 cells).
Article
Engineering, Biomedical
Paritat Thaitalay, Oranich Thongsri, Rawee Dangviriyakul, Sawitri Srisuwan, Louise Carney, Julie Elizabeth Gough, Sirirat Tubsungnoen Rattanachan
Summary: In this study, three different modified cements were evaluated for their physical properties and the response of primary human osteoblast cells and mesenchymal stem cells. Polyacrylic acid was found to improve the compressive strength and Young's modulus of the cement, but it had negative effects on apatite phase formation, setting time, and degradation. The addition of bioactive glass improved the physical properties of the cement and enhanced cell proliferation and differentiation, making it a promising formula for bone repair applications.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Materials Science, Multidisciplinary
Paritat Thaitalay, Chiara Giannasi, Stefania Niada, Oranich Thongsri, Rawee Dangviriyakul, Sawitri Srisuwan, Sanong Suksaweang, Anna Teresa Brini, Sirirat Tubsungnoen Rattanachan
Summary: The PAA-apatite/TCP cement modified with bioactive glass showed improved setting time, enhanced apatite phase transformation, and bioactivity. Cell proliferation was lower under indirect culture compared to control medium, while direct culture showed higher proliferation rates on both control cement and bioactive glass incorporated cement.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Naruporn Monmaturapoj, Theerawat Uanlee, Katanchalee Nampuksa, Anchittha Kasiwat, Chalumkwan Makornpan
Summary: Porous biphasic calcium phosphate scaffolds containing bioactive glass have been prepared, showing improved antibacterial activity, in vitro bioactivity, and mechanical properties. Different amounts of bioactive glass affect the density, shrinkage, and compressive strength of the scaffolds.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Vetharaj HephzibahRajam Arkin, Uttamchand Narendrakumar, Harishkumar Madhyastha, Inderchand Manjubala
Summary: Injectable calcium phosphate cement is a promising biomaterial for hard tissue repair, with recent developments in magnesium and strontium-doped cements showing improved setting time, mechanical strength, and cell attachment. The research aims to develop suitable self-setting cements with good biocompatibility, utilizing synthesized hydroxyapatite and additives for enhanced properties.
Article
Cell & Tissue Engineering
William C. W. Chen, James E. Baily, Mirko Corselli, Mary E. Diaz, Bin Sun, Guosheng Xiang, Gillian A. Gray, Johnny Huard, Bruno Peault
Review
Cell & Tissue Engineering
Arman Saparov, Vyacheslav Ogay, Talgat Nurgozhin, Medet Jumabay, William C. W. Chen
STEM CELLS INTERNATIONAL
(2016)
Article
Hematology
Sarah A. Beckman, William C. W. Chen, Ying Tang, Jonathan D. Proto, Logan Mlakar, Bing Wang, Johnny Huard
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2013)
Article
Hematology
Richard J. Bodnar, Margaret E. Rodgers, William C. W. Chen, Alan Wells
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2013)
Article
Engineering, Biomedical
Hunghao Chu, Chien-Wen Chen, Johnny Huard, Yadong Wang
Article
Cell & Tissue Engineering
Xueqin Gao, Arvydas Usas, Aiping Lu, Ying Tang, Bing Wang, Chien-Wen Chen, Hongshuai Li, Jessica C. Tebbets, James H. Cummins, Johnny Huard
CELL TRANSPLANTATION
(2013)
Article
Biochemistry & Molecular Biology
Xueqin Gao, Arvydas Usas, Jonathan D. Proto, Aiping Lu, James H. Cummins, Alexander Proctor, Chien-Wen Chen, Johnny Huard
Review
Biochemistry & Molecular Biology
Arman Saparov, Chien-Wen Chen, Sarah A. Beckman, Yadong Wang, Johnny Huard
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2013)
Review
Biotechnology & Applied Microbiology
Chien-Wen Chen, Mirko Corselli, Bruno Peault, Johnny Huard
JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
(2012)
Article
Orthopedics
Bo Zheng, Guangheng Li, William C. W. Chen, Bridget M. Deasy, Jonathan B. Pollett, Bin Sun, Lauren Drowley, Burhan Gharaibeh, Arvydas Usas, Bruno Peault, Johnny Huard
JOURNAL OF ORTHOPAEDIC RESEARCH
(2013)
Article
Multidisciplinary Sciences
Hongshuai Li, Arvydas Usas, Minakshi Poddar, Chien-Wen Chen, Seth Thompson, Bahar Ahani, James Cummins, Mitra Lavasani, Johnny Huard
Article
Cell & Tissue Engineering
Chien-Wen Chen, Masaho Okada, Jonathan D. Proto, Xueqin Gao, Naosumi Sekiya, Sarah A. Beckman, Mirko Corselli, Mihaela Crisan, Arman Saparov, Kimimasa Tobita, Bruno Peault, Johnny Huard
Review
Cell & Tissue Engineering
William C. W. Chen, Tea Soon Park, Iain R. Murray, Ludovic Zimmerlin, Lorenza Lazzari, Johnny Huard, Bruno Peault
STEM CELLS INTERNATIONAL
(2013)
Article
Multidisciplinary Sciences
William C. W. Chen, Arman Saparov, Mirko Corselli, Mihaela Crisan, Bo Zheng, Bruno Peault, Johnny Huard
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2014)
Article
Multidisciplinary Sciences
William C. W. Chen, Leonid Gaidukov, Yong Lai, Ming-Ru Wu, Jicong Cao, Michael J. Gutbrod, Gigi C. G. Choi, Rachel P. Utomo, Ying-Chou Chen, Liliana Wroblewska, Manolis Kellis, Lin Zhang, Ron Weiss, Timothy K. Lu
Summary: In this study, a highly tunable, modular, and versatile CRISPR-based synthetic transcription system was developed for programmable control of gene expression and cellular phenotypes in mammalian cells. The system allows for predictable and tunable regulation of gene expression and cellular function in multiple cell types.
NATURE COMMUNICATIONS
(2022)