Article
Plant Sciences
Dongyue Yu, Ruoqi Huang, Shuxia Yu, Qiong Liang, Ying Wang, Haishan Dang, Yanjun Zhang
Summary: This study focused on QTL mapping of flavonoid and leaf-size related traits in Epimedium, and identified 46 stable QTLs. These findings are significant for breeding and gene investigation in Epimedium.
Review
Integrative & Complementary Medicine
Chenyang Ai, Yi Zou, Hao Liu, Zheqiong Yang, Jinlei Xi
Summary: The prevalence of allergic disorders has increased, leading to a lower quality of life for patients and a higher demand for drugs to treat these diseases. Traditional Chinese medicine offers distinct benefits in treating allergic illnesses, such as long-term treatment maintenance, prevention of disease recurrence, and fewer adverse reactions. Recent developments in Chinese herbal formula, Chinese patent medicine, and active ingredients of traditional Chinese medicine have been analyzed, discussing their components, efficacy, and mechanisms of action. The importance of improving traditional Chinese herbal formulas and developing safe and effective Chinese patent medicines is emphasized in the field of traditional Chinese medicine research.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Integrative & Complementary Medicine
Jillian L. Capodice, Barbara M. Chubak
Summary: Traditional Chinese Medicine (TCM) is a comprehensive medical system that has been developed over thousands of years and is utilized in the treatment of COVID-19. This paper highlights the use of TCM in treating COVID-19, discussing concepts and challenges of integrating TCM into medical settings.
Review
Pharmacology & Pharmacy
Liu Liu, Lei Zhang, Ming Li
Summary: Lupus nephritis is a renal disease caused by systemic lupus erythematosus and has serious implications for patients. Traditional Chinese medicine has shown promising effects in alleviating the symptoms and improving the prognosis of LN patients. This review provides supplementary evidence for the development of TCM treatment for LN and serves as a reference for future research and clinical practice.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Plant Sciences
Liangshuai Liu, Heping Li, Guosheng Tan, Zhenjiang Ma
Summary: This study reviewed the use of traditional Chinese herbal medicine in treating amenorrhea caused by antipsychotic drugs and conducted a meta-analysis. The results showed that Chinese herbal medicine can effectively treat this condition, although it may take a long time to achieve satisfactory effectiveness.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Shan Wu, Chuanchi Wang, Dong Bai, Nanjie Chen, Jingqing Hu, Junhua Zhang
Summary: With the introduction of clinical epidemiology and evidence-based medicine, Traditional Chinese Herbal Medicine (TCHM) in China has improved and internationalization of Traditional Chinese Medicine (TCM) has accelerated. Many Chinese drug products have been approved for marketing in other countries, and several Chinese herbal preparations have been investigated in phase III clinical trials. However, international multi-center clinical trials of TCHM are rare and improvement in evaluation techniques and methods that meet international standards and TCHM characteristics is required.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Integrative & Complementary Medicine
Purumea Jun, Endang Rahmat, Chang-Hyun Han, Changsop Yang, Youngmin Kang
Summary: The decline in birth rates is a serious issue globally, with many countries implementing national programs to increase birth rates using traditional medicines. This review analyzed and compared herbal medicines from traditional Chinese medicine (TCM) and traditional Indonesian medicine (TIM) that pregnant women should avoid for preventing miscarriage and maintaining safety. Despite their differences, TCM and TIM share similarities in concept and treatment, especially regarding herbal medicines, making this review a useful reference for pregnant women to consume herbal medicines safely.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Muhammad Harith Zulkifli, Zafirah Liyana Abdullah, Nur Intan Saidaah Mohamed Yusof, Fazlin Mohd Fauzi
Summary: This article summarizes three in silico approaches for toxicity studies of Traditional Chinese medicine (TCM) herbal medicine, including machine learning, network toxicology, and molecular docking. Although these methods can provide data-driven toxicity prediction validated in vitro and/or in vivo, they are limited to single compound analysis and specific types of toxicity. Future studies should involve testing combinations of compounds to improve in silico toxicity modeling of TCM compounds.
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2023)
Review
Plant Sciences
Ya-Ting Wang, Xiao-Le Wang, Zhen-Zhen Wang, Lan Lei, Die Hu, Yi Zhang
Summary: This review summarizes the antidepressant mechanisms of Xiao-Yao-San (XYS) and its active ingredients, which are reportedly correlated with monoamine neurotransmitter regulation, synaptic plasticity, and hypothalamic-pituitary-adrenal axis. XYS plays a critical role in the treatment of depression by regulating several factors and pathways. However, more clinical and animal studies are needed to further investigate the antidepressant function of XYS and provide more evidence and recommendations for its clinical application.
Review
Biochemistry & Molecular Biology
Jose M. Prieto, Guillermo R. Schinella
Summary: This experimental review explores the relationship between Traditional Chinese Medicine (TCM) herbal drugs and lipid peroxidation in the context of topical inflammation. The study finds that certain herbal drugs with bitter and cold properties inhibit both lipid peroxidation and eicosanoids production, while sweet drugs specifically inhibit eicosanoids production. The therapeutic value of other drugs may be based on their actions on the Qi. The study suggests potential translation between the two medical systems and provides insights for the treatment of skin conditions.
Review
Biochemistry & Molecular Biology
Blanca Ibanez, Ana Melero, Alegria Montoro, Juan F. Merino-Torres, Jose M. Soriano, Nadia San Onofre
Summary: In recent years, there has been increasing interest in finding natural radioprotectors to mitigate the harmful effects of radiation. This review examines herbal preparations from Ayurvedic, Traditional Chinese, and Kampo Medicines that have demonstrated potential radioprotective effects. Ten herbal preparations, including Abana, Amalakyadi Churna, Amritaprasham, Brahma, Bu-zhong-yi-qi-tang (BZYQT), Chyavanaprasha, Cystone, Geriforte, Mentat, and Triphala, are highlighted for their potential radioprotective properties. Exploring the ethnobotany of traditional Asian medicine may lead to the discovery of new active compounds with radioprotective properties.
Review
Plant Sciences
Myong Hak Ri, Yue Xing, Hong Xiang Zuo, Ming Yue Li, Hong Lan Jin, Juan Ma, Xuejun Jin
Summary: This review summarizes the regulatory mechanisms of natural compounds derived from traditional Chinese herbal medicines on the microglial response in animal models of ischemic stroke. The findings suggest that these compounds attenuate the M1 phenotype of microglia, which is involved in detrimental inflammatory response, while enhancing the neuroprotective M2 phenotype. Clinical trials also show significant and safe therapeutic effects, but further well-designed studies are needed.
Article
Environmental Sciences
Yi Wang, Yuan Li, Shuai Yang, Qi-Hao Wang, Shao-Cheng Si, Han-Yi Mei, Guo-Ming Liu, Xiang-Liang Pan, Yong-Ming Luo
Summary: Soil washing is an effective method for removing heavy metals from farmland soil, and the choice of washing agents is crucial for the efficiency of the removal. This study tested the potential of three residues of traditional Chinese herbal medicine extracts for Cd removal and identified the optimal conditions. The results showed that the extract from Prunus mume residues was a more feasible and environmentally friendly washing agent.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Liping Qu, Xiuli Li, Yin Xiong, Zhun Wang, Yuehua Zhou, Wenjun Zou, Jianyuan Tang, Mei Wang
Summary: Although TCM herbal remedies are popular in European patients, the access of multi-herbal TCM products to the EU market faces considerable obstacles. This study systematically analyzes the current advances in EU herbal monographs and combination herbal medicinal products (HMPs) granted in member states, and identifies the main features and challenges for multi-herbal TCM products. The results show that the EU is open to combination HMPs, but safety, efficacy, and justification of combinations are key elements for their market access.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Congying Wang, Shuyun Tian, Qin Tang, Ziwei Zhou, Xinheng Peng, Xiaoxue Cai, Yanqin Xu
Summary: This study evaluated the quality of Epimedium wushanense using two quality control standards and found significant differences in quality among different populations. All populations had higher total flavonoid glycoside content than the quality standard in the Chinese Pharmacopoeia, but with slightly lower mean values. Epimedin C was identified as the most abundant component in Epimedium wushanense.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Oncology
Jui-Feng Lin, Yen-Shuo Liu, Yu-Chuen Huang, Chih-Wen Chi, Cheng-Chia Tsai, Tung-Hu Tsai, Yu-Jen Chen
Summary: Borneol and tetrandrine may enhance the penetration of 5-FU into the brain by modulating the integrity of BBB and BTB. The experimental results showed that borneol and tetrandrine reduced BBB integrity, partially inhibited the efflux pump function of P-gp, and the combination of the two effectively prolonged survival.
INTEGRATIVE CANCER THERAPIES
(2022)
Article
Oncology
Yung-Yi Cheng, Teresa Zheng, Michael W. Chang, Jeffrey W. Dalley, Yu-Jen Chen, Tung-Hu Tsai, Chen-Hsi Hsieh
Summary: This study investigated the potential interaction between radiotherapy (RT) and tamoxifen treatment by evaluating the pharmacokinetics of tamoxifen during concurrent and sequential RT. The results demonstrated that RT may enhance the metabolism of tamoxifen to active metabolites, suggesting potential benefits of combining RT-tamoxifen for hormone-dependent breast cancer treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tun-Sung Huang, Chih-Jung Ko, Jiunn-Chang Lin, Ming-Ling Hsu, Chun-Chuan Ko, Chih-Wen Chi, Tung-Hu Tsai, Yu-Jen Chen
Summary: We investigated the effects of 6-MITC and its derivatives on the differentiation and maturation of human myeloid dendritic cells, as well as on skin transplantation. The results showed that these compounds could inhibit the expression of CD1a and CD83, and have both enhancing and inhibitory effects on T cells and interferon-gamma. Additionally, they prolonged the survival of skin allografts and induced the accumulation of regulatory T cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Ling Yang, I-Hsin Lin, Lie-Chwen Lin, Jeffrey W. Dalley, Tung-Hu Tsai
Summary: This study demonstrates through experiments that remdesivir and its main metabolite, GS-441524, can cross the placenta, but remdesivir itself cannot directly enter the fetus. This finding suggests that caution should be taken when using remdesivir to treat COVID-19 during pregnancy.
Article
Medicine, Research & Experimental
Jung-Hung Chen, I-Hsin Lin, Chung-Kai Sun, Ling Yang, Thomas Y. Hsueh, Chin-Tsung Ting, Tung-Hu Tsai
Summary: This study reveals the transplacental transfer mechanism of acetaminophen and provides valuable information for its clinical use in pregnant women.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Plant Sciences
Jung-Hung Chen, I-Hsin Lin, Thomas Y. Hsueh, Jeffrey W. Dalley, Tung-Hu Tsai
Summary: This study aimed to investigate the metabolism, distribution, and transplacental transfer mechanism of codeine and its metabolites in pregnant rats, as well as to assess the risk of medication for pregnant women.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Biochemical Research Methods
Chung-Kai Sun, Tung-Hu Tsai
Summary: This review compiles and analyzes original articles on understanding possible herb-drug interactions between traditional herbs and four major pain medications-acetaminophen, aspirin, ibuprofen, and naproxen. The most common analytical method used is high-performance liquid chromatography with an isocratic eluent system coupled to biological sample clean-up, and a wide variety of detectors have been observed. Synergistic and anti-synergistic effects were observed for acetaminophen and aspirin, while only synergistic effects have been found for naproxen. Currently, no interactions have been reported for ibuprofen.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Medicine, Research & Experimental
Ling Yang, Tung-Hu Tsai
Summary: The combination treatment of Gastrodia elata extract and valproic acid (VPA) can increase the VPA levels in the brain, enhance its antiepileptic effects, and exert synergistic anticonvulsive effects by protecting neurons and altering dopamine metabolite levels. This synergistic effect is mediated by transporters at the blood-brain barrier.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Tun-Pin Hsueh, Tung-Hu Tsai
Summary: This study investigated the diuretic effects and pharmacokinetics of Yin-Chen-Hao-Tang (YCHT) in combination with spironolactone in bile duct-ligated rats. The results showed that the coadministration of YCHT and spironolactone decreased urinary sodium excretion and urine output.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yu-Chuen Huang, Pei-Ying Hsieh, Li-Ying Wang, Tung-Hu Tsai, Yu-Jen Chen, Chen-Hsi Hsieh
Summary: The aim of this study was to evaluate the radiotherapy (RT)-pharmacokinetics (PK) effect of cabozantinib in concurrent or sequential regimens with external beam radiotherapy (EBRT) or stereotactic body radiation therapy (SBRT). The RT-drug interactions of cabozantinib under RT were confirmed in a free-moving rat model. The biodistribution of cabozantinib in the heart is modulated by off-target irradiation and SBRT doses simultaneously.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jui-Feng Lin, Chih-Wen Chi, Yu-Chuen Huang, Tung-Hu Tsai, Yu-Jen Chen
Summary: In this study, the anti-cancer effects of 6-MITC and its derivatives on chronic myelogenous leukemia cells were examined. It was found that they can induce cell death through suppressing the cell cycle and inducing autophagy and aberrant mitosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Su-Yin Chiang, Ming-Tsai Wey, Yu-Syuan Luo, Wei-Chung Shih, Dalaijamts Chimeddulam, Po-Chi Hsu, Hui-Fen Huang, Tung-Hu Tsai, Kuen-Yuh Wu
Summary: This study used a novel microdialysis sampling coupled with solid-phase extraction liquid chromatography-tandem mass spectrometry (MD-SPE-LC-MS/MS) to investigate the toxicokinetics (TK) of AA-I and AA-II and their corresponding aristolactams (AL-I and AL-II) in Sprague Dawley rats. Real-time monitoring revealed that AA-I was absorbed, distributed, and eliminated more rapidly than AA-II. The metabolism efficiency of AA-I to AL-I was higher compared to AA-II to AL-II. These findings support the hypothesis that differences in the in vivo metabolism of AA-I and AA-II may contribute to their differential toxicities.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Chemistry, Analytical
Chun-Hao Chang, Wen-Ya Peng, Wan-Hsin Lee, Tung-Yi Lin, Muh-Hwa Yang, Jeffrey W. Dalley, Tung-Hu Tsai
Summary: The aim of this study was to investigate the effects of herbal drug interactions on the biotransformation of molnupiravir and its metabolite NHC in the blood and brain. The results showed that molnupiravir was rapidly metabolized to NHC and penetrated into the brain.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Medicine, General & Internal
Chun-Hao Chang, Wen-Ya Peng, Wan-Hsin Lee, Tung-Yi Lin, Muh-Hwa Yang, Jeffrey W. Dalley, Tung-Hu Tsai
Summary: This study investigated the pharmacokinetics and transplacental transfer of molnupiravir, an antiviral drug for COVID-19, in pregnant rats. The results showed that molnupiravir is rapidly metabolized to NHC and crosses the blood-placenta barrier, suggesting its therapeutic effect in pregnant patients infected with COVID-19.
Article
Medicine, Research & Experimental
Chun-Hao Chang, Wen-Ya Peng, Wan-Hsin Lee, Ling Yang, Tung-Yi Lin, Muh-Hwa Yang, Tung-Hu Tsai
Summary: Molnupiravir and its metabolite NHC can penetrate the blood-brain barrier and reach brain tissue, and the penetration of NHC can be modulated by NBMPR. These findings provide valuable information for understanding brain disorders in COVID-19 patients.
COMMUNICATIONS MEDICINE
(2023)