Article
Cell Biology
Chandranayaka Siddaiah, Anil Kumar BM, Saligrama Adavigowda Deepak, Syed Salman Lateef, Saurabh Nagpal, Kanchugarakoppal S. Rangappa, Chakrabhavi D. Mohan, Shobith Rangappa, Madan S. Kumar, Minaxi Sharma, Vijai Kumar Gupta
Summary: This study focused on metabolite profiling and identification from the bark of Alangium salviifolium by using organic and aqueous solvents. Eighty-one secondary metabolites with therapeutic potential were identified, showcasing the therapeutic value of this plant.
Article
Plant Sciences
Minyi Zhang, Tao Zhang, Chenglin Song, Jiao Qu, Yanpin Gu, Songjun Liu, Haibo Li, Wei Xiao, Lingdong Kong, Yang Sun, Wen Lv
Summary: The study suggests that GFC may alleviate estrogen-induced endometrial hyperplasia through triggering ferroptosis and inhibiting the p62-Keap1-NRF2 pathway. These findings indicate that GFC could be a promising traditional Chinese medicine for treating endometrial hyperplasia.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Yan He, Zhenkun Zhou, Weijie Li, Yanqiong Zhang, Ruoyao Shi, Tao Li, Linlin Jin, Hongliang Yao, Na Lin, Hao Wu
Summary: This study characterized the chemical constituents and metabolism pathways of Baihu-Guizhi decoction in vivo using liquid chromatography and mass spectrometry techniques. The study identified the absorbed components and metabolites of the decoction and established a quantitative method to monitor their pharmacokinetic behaviors. The findings provide valuable insights into the pharmacological effects and mechanism of Baihu-Guizhi decoction.
Article
Pharmacology & Pharmacy
Siqin Zhang, Xinxing Lai, Xin Wang, Gang Liu, Zhenzhong Wang, Liang Cao, Xinzhuang Zhang, Wei Xiao, Shao Li
Summary: By integrating computational and experimental methods, this study successfully identified potential functional modules and bioactive compounds of Guizhi-Fuling capsule (GZFLC) for primary dysmenorrhea. The study also verified the anti-dysmenorrhea mechanisms of GZFLC, showing significant inhibition of pain response and reduction of uterine lesions in oxytocin-induced dysmenorrhea murine model. These findings suggest that GZFLC may alleviate primary dysmenorrhea by inhibiting cyclooxygenase 2 (COX2) and downregulating MAPK signaling pathway, providing pain relief and sustained benefits.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Jing Wan, Peng He, Yuanshan Chen, Qiujin Zhu
Summary: A practical, efficient, and rapid method for quantifying 19 pyrethroids in tea and orange samples was developed. Out of 262 tea samples, 11 pyrethroids were detected positive with concentrations below maximum residue limits. No pyrethroid was found in 209 peeled orange samples.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Review
Chemistry, Analytical
Hugo M. Santos, Luis B. Carvalho, Carlos Lodeiro, Goncalo Martins, Ines L. Gomes, Wilson D. T. Antunes, Vanessa Correia, Maria M. Almeida-Santos, Helena Rebelo-de-Andrade, Antonio P. A. Matos, J. L. Capelo
Summary: This work presents a tutorial on the capabilities of bioanalytical mass spectrometry in detecting and differentiating viruses at the peptide level, as well as providing diagnosis and prognosis for infected patients. It offers insights into the possibilities of current high-resolution mass spectrometry technology and bioinformatics.
MICROCHEMICAL JOURNAL
(2023)
Article
Plant Sciences
Linwei Chen, Honglin Chen, Qiaowei Yang, Yong Jiang, Lunyuan Liu, Hui Yu, Yan Chen, Jindong Li, Nan Chen, Hua Wang, Qin Wang
Summary: This study revealed that Guizhi Fuling Capsule (GFC) inhibited the growth of uterine fibroids (UFs) by modulating the Med12-mediated Wnt/ll-Catenin signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Weili Pan, Hui Dong, Rong Sun, Linlin Zhao, Meng Sun, Longyan Li, Xianghao Yu, Jinxin Liu, Jianjun Wu, Fan Yang, Bo Yu
Summary: The study found an association between plasma ceramides and culprit plaque vulnerability evaluated using optical coherence tomography, supporting the proatherogenic role of ceramides.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Yan He, Weiwei Su, Xiang He, Taobin Chen, Xuan Zeng, Zenghao Yan, Weijian Zhang, Wei Yang, Jianmin Guo, Hao Wu
Summary: This study identified and characterized the components of Naoxintong Capsule in beagle dog plasma, as well as proposed the in vivo bio-transformation pathways. By developing a quantitative method for crucial components and conducting plasma pharmacokinetic study, insights into the absorbed components profiling and in vivo transformation behaviors of NXTC were provided for future investigations on efficacy-contributing critical components and mechanisms.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Food Science & Technology
Rajender Kumar, Dinesh Kumar
Summary: Allium is widely consumed as a spice around the world. This study compared the metabolome and antioxidant activity of different tissues of Allium cepa, A. sativum, and A. semenovii. The results showed that A. cepa and A. semenovii had higher antioxidant activity and polyphenol content compared to A. sativum. Additionally, various metabolites including polyphenols and sulfur containing compounds were identified. This study highlights the potential of A. semenovii for utilization in food and nutraceuticals.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Qiong Chen, Ting Zhou, Jun-jie Yuan, Xiao-yi Xiong, Xue-hui Liu, Zong-ming Qiu, Lin-lin Hu, Hui Lu, Qian He, Chang Liu, Qing-wu Yang
Summary: This study investigated the metabolic alterations during ischemia-reperfusion injury using metabolomic analysis. A total of 82 differentially expressed metabolites were identified, with some significantly elevated in the reperfusion group. Metabolomics pathway analysis revealed the importance of glycerophospholipid metabolism, linoleic acid metabolism, pyrimidine metabolism, and galactose metabolism in the response to cerebral ischemia-reperfusion. This study provides important insights into the metabolic changes induced by cerebral ischemia-reperfusion.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Integrative & Complementary Medicine
Sun Run-jie, Xu Jie, Gao Wei, Zhang Yan-yu, Sun Xiao-qi, Ji Lin, Cui Xing
Summary: The study found that Guizhi Fuling Capsule can promote the apoptosis of myeloma cells through the mitochondrial apoptosis pathway, reduce tumor volume, and prolong the survival time of mice with myeloma.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Jinpeng Chen, Xiaohong Gai, Xu Xu, Yi Liu, Tao Ren, Suxiang Liu, Ting Ma, Chengwang Tian, Changxiao Liu
Summary: Guizhi Fuling prescription (GFP), a traditional Chinese medicine formula, contains bioactive ingredients such as amygdalin, cinnamic acid, and paeoniflorin, which play crucial roles in treating diseases like endometriosis. Through the investigation, these components were identified as potential Quality Markers for GFP, providing a new method for quality evaluation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Plant Sciences
Qiulong Zhao, Jiaxin Cheng, Xiaokun Bian, Chunxue Wang, Yi Xu, Hongxiang Ding, Hui Ren, Yiying Zhang, Min Xu, Chenxiao Shan, Hui Yan, Jinao Duan, Dawei Qian, Xi Huang
Summary: This study evaluated the pharmacokinetics of Guizhi-Fuling capsule in rats and found that the absorbed components contributed to the efficacy of the source herbs. Specifically, 11 active ingredients exerted anti-dysmenorrhea effects through regulating a specific pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Construction & Building Technology
Stepanka Kuckova, Gabriela Rambouskova, Petra Junkova, Jiri Santrucek, Pavel Cejnar, Tatiana Anatolievna Smirnova, Ondrej Novotny, Radovan Hynek
Summary: The enrichment of mortar mixtures with natural organic materials has a long history, with protein additives proven to enhance mortar durability and strength. This study aimed to identify and quantify proteins in model mortars with various protein additives using mass spectrometry techniques. The results confirmed the possibility of identifying protein additives in century-old mortars, shedding light on traditional recipes.
CONSTRUCTION AND BUILDING MATERIALS
(2021)
Article
Biochemical Research Methods
Jun Cao, Ping Li, Jue Chen, Ting Tan, Han-Bin Dai
Article
Chemistry, Applied
Guo-Dong Zheng, Ping Zhou, Hua Yang, Yue-shan Li, Ping Li, E. -Hu Liu
Article
Neurosciences
Ju Wang, Zi-Qi Shi, Xiaojun Xu, Gui-Zhong Xin, Jun Chen, Lian-Wen Qi, Ping Li
JOURNAL OF ALZHEIMERS DISEASE
(2013)
Article
Biochemical Research Methods
Lian-Wen Qi, Huai-You Wang, Hui Zhang, Chong-Zhi Wang, Ping Li, Chun-Su Yuan
JOURNAL OF CHROMATOGRAPHY A
(2012)
Article
Biochemical Research Methods
Hao Wang, Zhenzhou Jiang, Huibing Du, Chunyi Liang, Yuanchao Wang, Mohan Zhang, Luyong Zhang, Wencai Ye, Ping Li
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2012)
Article
Biochemical Research Methods
Gui-Zhong Xin, Liu Cao, Zi-Qi Shi, Hui-Jun Li, Xiao-Dong Wen, Jun Chen, Lian-Wen Qi, Ping Li
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2012)
Article
Chemistry, Analytical
Hui Zhang, Shao-Qing Wang, Ying Liu, Li-Ping Luo, Peng Liu, Lian-Wen Qi, Ping Li
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2012)
Article
Chemistry, Analytical
Jiang Ma, Lian-Wen Qi, Hui-Jun Li, Ping Li
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2012)
Article
Chemistry, Analytical
Cui-Li Li, Jiang Ma, Li Zheng, Hui-Jun Li, Ping Li
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2012)
Article
Chemistry, Analytical
Rong-Hua Ma, Jie Yang, Lian-Wen Qi, Gui-Zhong Xin, Chong-Zhi Wang, Chun-Su Yuan, Xiao-Dong Wen, Ping Li
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2012)
Article
Chemistry, Analytical
Yu Fu, Wen Gao, Jun-jie Yu, Jun Chen, Hui-jun Li, Ping Li
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2012)
Article
Chemistry, Analytical
Xiao-Dong Wen, E-Hu Liu, Jie Yang, Chang-Yin Li, Wen Gao, Lian-Wen Qi, Chong-Zhi Wang, Chun-Su Yuan, Ping Li
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2012)
Article
Biochemistry & Molecular Biology
Yingjie Wei, Ping Li, Changmei Wang, Yunru Peng, Luan Shu, Xiaobin Jia, Wenquan Ma, Bing Wang
Article
Chemistry, Medicinal
Li Zhang, Sheng-Ye Yang, Feng-Rong Qi-Li, Xiao-Xiao Liu, Wei-Tao Zhang, Chao Peng, Ping Wu, Ping Li, Pingping Li, Xiaojun Xu
Summary: Isoliquiritigenin (ISO) is a lipid-lowering compound that improves nonalcoholic fatty liver disease and nonalcoholic steatohepatitis by regulating SIRT1 expression. IQGAP2 was identified as the direct target of ISO in lipid homeostasis regulation, and a novel IQGAP2-CREB-SIRT1 axis was demonstrated for the first time in treating NAFLD/NASH.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hui-Min Cheng, Mingming Xing, Ya-Ping Zhou, Weitao Zhang, Zeyu Liu, Lan Li, Zuguo Zheng, Yuanchen Ma, Pingping Li, Xiaoxuan Liu, Ping Li, Xiaojun Xu
Summary: Heat shock protein 90 beta (Hsp90 beta) plays a specific role in osteoclasts by binding to Ikk beta, reducing its degradation, and promoting NF-kappa B signaling. It also increases cholesterol biosynthesis, leading to the expression of osteoclastogenic genes. Inhibiting or deleting Hsp90 beta can alleviate bone loss in osteoporosis.
CELL DEATH AND DIFFERENTIATION
(2023)