期刊
JOURNAL OF CELL BIOLOGY
卷 209, 期 2, 页码 195-198出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1083/jcb.201501034
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- Intramural NIH HHS Funding Source: Medline
Matrix degradation is central to tumor pathogenesis. Enzymes that degrade extracellular matrix are abundant in tumors. But which out of the complex mixture of cells that form a tumor produces them? Surprisingly, several hundred studies devoted to this question have provided confusion rather than clarity. Our analysis of these studies identifies likely reasons as to why this may be the case, which has implications for the broader issue of research reproducibility.
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