Article
Critical Care Medicine
Farzad Moazed, Carolyn Hendrickson, Alejandra Jauregui, Jeffrey Gotts, Amanda Conroy, Kevin Delucchi, Hanjing Zhuo, Mikhaela Arambulo, Kathryn Vessel, Serena Ke, Thomas Deiss, Amy Ni, Aleksandra Leligdowicz, Jason Abbott, Mitchell J. Cohen, Pratik Sinha, Antonio Gomez, Kirsten Kangelaris, Lucy Kornblith, Michael Matthay, Neal Benowitz, Kathleen Liu, Carolyn S. Calfee
Summary: Cigarette smoke exposure is associated with an increased risk of developing ARDS in both pulmonary and nonpulmonary sepsis patients. Among ARDS patients, those with exposure to cigarette smoke have lower systemic inflammation levels, and active smokers also have lower severity of illness compared to non-smokers, indicating that smoking contributes to biological heterogeneity in ARDS.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Ryan H. Nguyen, Laura B. Vater, Lava R. Timsina, Gregory A. Durm, Katelin Rupp, Keylee Wright, Miranda H. Spitznagle, Brandy Paul, Shadia Jalal, Lisa Carter-Harris, Karen S. Hudmon, Nasser H. Hanna, Patrick J. Loehrer, DuyKhanh P. Ceppa
Summary: The study found that counties with stronger smoke-free air ordinances had lower smoking rates and fewer new lung cancer cases per year. Therefore, strengthening smoke-free air ordinances is crucial for reducing lung cancer incidence.
Article
Neurosciences
Hao Hu, Jun-Ting Fu, Yan-Lin Bi, Ya-Hui Ma, Yu-Yuan Huang, Xin Wang, Lan Tan, Jin-Tai Yu
Summary: This study found an association between cigarette smoking and cognitive impairment as well as tau pathologies. The effects of smoking on cognition and tau pathologies worsened with greater cumulative cigarette exposure, independent of A beta pathology. Smoking was found to have a partial mediation effect on cognition through tau pathologies. Long-term smoking cessation was found to mitigate both cognitive impairment and tau pathologies.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Oncology
Tommaso A. Dragani, Thomas Muley, Marc A. Schneider, Sonja Kobinger, Martin Eichhorn, Hauke Winter, Hans Hoffmann, Mark Kriegsmann, Sara Noci, Matteo Incarbone, Davide Tosi, Sara Franzi, Francesca Colombo
Summary: This study examined the relationships between smoking habit, clinical stage, and sex with age at diagnosis of lung adenocarcinoma. The results showed that smoking, advanced stage, and female sex were associated with younger age at diagnosis. This study provides new insights into the clinical variables influencing age at diagnosis and opens up possibilities for further research on the genetic and molecular mechanisms responsible for these associations.
Article
Dentistry, Oral Surgery & Medicine
Zohaib Akram, Sultan Aati, Ali Alrahlah, Fahim Vohra, Amr Fawzy
Summary: The study showed that cigarette smokers had higher deterioration of periodontal health compared to e-cigarette smokers. Smoking, MMP-8, and CTX were identified as prognostic factors for clinical attachment loss in both cigarette and e-cigarette smokers.
JOURNAL OF DENTISTRY
(2021)
Article
Public, Environmental & Occupational Health
Aline F. Fares, Yao Li, Mei Jiang, M. Catherine Brown, Andrew C. L. Lam, Reenika Aggarwal, Sabine Schmid, Natasha B. Leighl, Frances A. Shepherd, Zhichao Wang, Nancy Diao, Angela S. Wenzlaff, Juntao Xie, Takashi Kohno, Neil E. Caporaso, Curtis Harris, Hongxia Ma, Matthew J. Barnett, Leticia Ferro Leal, G. Fernandez-Tardon, Manica Perez-Rios, Michael P. A. Davies, Fiona Taylor, Ben Schoettker, Paul Brennan, David Zaridze, Ivana Holcatova, Jolanta Lissowska, Beata Swiatkowska, Dana Mates, Milan Savic, Hermann Brenner, Angeline Andrew, Angela Cox, John K. Field, Alberto Ruano-Ravina, Sanjay S. Shete, Adonina Tardon, Ying Wang, Loic Le Marchand, Rui Manuel Reis, Matthew B. Schabath, Chu Chen, Hongbing Shen, Brid M. Ryan, Maria Teresa Landi, Kouya Shiraishi, Jie Zhang, Ann G. Schwartz, Ming S. Tsao, David C. Christiani, Ping Yang, Rayjean J. Hung, Wei Xu, Geoffrey Liu
Summary: This large-scale study conducted in multiple countries and regions worldwide found that the duration of smoking abstinence is associated with overall survival in patients with NSCLC, even when diagnosed at a later lung-cancer screening visit.
LANCET PUBLIC HEALTH
(2023)
Article
Medicine, Research & Experimental
Tingting Wu, Keye Xu, Chaobo Liu, Yan Li, Mingcai Li
Summary: This study aimed to investigate the effect of interleukin-37 (IL-37) on cigarette smoke-induced lung inflammation. By administering IL-37-expressing lentivirus to mice, it was found that IL-37 can alleviate weight loss and pulmonary inflammation induced by cigarette smoke. IL-37 also significantly inhibited inflammatory cell recruitment, reduced inflammatory cell increase, and suppressed the production of pro-inflammatory cytokines.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Alexander J. Kaiser, Cassie Salem, Bob J. Alvarenga, Anthony Pagliaro, Kelly P. Smith, Luis G. Valerio, Kambez H. Benam
Summary: The addition of Vitamin E acetate was found to significantly alter the size distribution of particles inhaled from electronic cigarettes and increase the total amount of particles inhaled. The biologically inspired robotic system proved its utility in studying the effects of nicotine and different breathing profiles associated with obstructive and restrictive lung disorders. This system is expected to be a novel preclinical scientific research and decision-support tool when examining the toxicological impacts of modifications in electronic nicotine delivery systems.
Article
Rheumatology
Jiaqi Ren, Yanling Ding, Jinxia Zhao, Yongchang Sun
Summary: This study aimed to investigate the clinical and radiological features and prognosis of male smoker patients with rheumatoid arthritis (RA). The study found that smoker patients with RA had more respiratory symptoms, a higher positive rate of rheumatoid factor (RF), and showed more emphysema and signs of lung fibrosis on chest high-resolution computed tomography (HRCT) compared to never-smokers. However, cigarette smoking was not the risk factor for survival, but lung fibrosis on HRCT was.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sylvia Nyilas, Grzegorz Bauman, Insa Korten, Orso Pusterla, Florian Singer, Michael Ith, Cindy Groen, Anna Schoeni, Johannes T. Heverhagen, Andreas Christe, Nicolas Rodondi, Oliver Bieri, Thomas Geiser, Reto Auer, Manuela Funke-Chambour, Lukas Ebner
Summary: This prospective observational study examined the immediate effects of electronic nicotine delivery systems (ENDS) and tobacco smoke on lung ventilation and perfusion. The results showed a decrease in lung perfusion after exposure to tobacco smoke and an increase in lung perfusion after using ENDS.
Article
Multidisciplinary Sciences
Vikram R. Shaw, Jinyoung Byun, Rowland W. Pettit, Younghun Han, David A. Hsiou, Luke A. Nordstrom, Christopher I. Amos
Summary: Lung cancer is the leading cause of cancer-related deaths in the US. This study used the All of Us database to compare healthcare access, family history, smoking behaviors, and psychiatric comorbidities in different groups of lung cancer patients and controls. The results showed differences in healthcare access and psychiatric burdens among different groups, providing valuable insights into disease management.
SCIENTIFIC REPORTS
(2023)
Article
Substance Abuse
Gang Liu, Chi Jen Lin, Charles R. Yates, G. L. Prasad
Summary: Switching from smoking to Vuse ENDS within 5 days resulted in significantly reduced levels of nicotine-derived metabolites and xenobiotics in urine and plasma, indicating decreased toxicant exposure and oxidative stress. Meanwhile, levels of plasma glutathione metabolites decreased, suggesting reduced oxidative stress, and levels of vitamins and antioxidants increased, implying potential beneficial changes in vitamin metabolism due to discontinuation of cigarette smoking.
NICOTINE & TOBACCO RESEARCH
(2021)
Article
Immunology
Tiantian Cen, Yifeng Mai, Jie Jin, Minxuan Huang, Mingcai Li, Shanshan Wang, Hongying Ma
Summary: Our study aimed to investigate the ability of IL-41 to protect against CS-induced lung inflammation in vivo. The results showed that IL-41 pre-treatment alleviated pulmonary inflammatory infiltration and lung tissue lesions, limited CS-induced weight loss, and promoted the polarization of M2 macrophages. IL-41 also increased the levels of IL-10 and reduced the production of TNF-α, IL-6, and IL-1β.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Nadia Milad, Marie Pineault, Felix Tremblay, Joanie Routhier, Ariane Lechasseur, Marie-Josee Beaulieu, Sophie Aubin, Mathieu C. Morissette
Summary: This study compared the anti-inflammatory effects of IL-1 alpha signaling blockade during active cigarette smoke exposure and during the cessation period using a pre-clinical model. The results showed that blocking IL-1 alpha signaling during smoke exposure delayed the inflammatory response, while the same treatment during cessation accelerated the return to pulmonary inflammatory homeostasis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Jeng-Sen Tseng, Chun-Ju Chiang, Kun-Chieh Chen, Zhe-Rong Zheng, Tsung-Ying Yang, Wen-Chung Lee, Kuo-Hsuan Hsu, Yen-Hsiang Huang, Tsang-Wu Liu, Jiun-Yi Hsia, Gee-Chen Chang
Summary: This retrospective cohort study evaluated the epidemiologic factors, clinical characteristics, and outcomes of small cell lung carcinoma (SCLC) in never-smokers. The results showed that the percentage of SCLC among never-smokers remained relatively stable, with never-smokers being more commonly older, female, with poorer performance status, advanced stage cancer, and without treatment compared to smokers. Additionally, never-smokers, particularly men, had a lower survival rate.
Correction
Chemistry, Analytical
Grzegorz Straczynski, Tomasz Ligor
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2019)
Article
Biochemical Research Methods
Ileana-Andreea Ratiu, Tomasz Ligor, Victor Bocos-Bintintan, Jacek Szeliga, Katarzyna Machala, Marek Jackowski, Boguslaw Buszewski
JOURNAL OF BREATH RESEARCH
(2019)
Article
Food Science & Technology
Ileana Andreea Ratiu, Hossam Al-Suod, Magdalena Ligor, Tomasz Ligor, Aneta Krakowska, Ryszard Gorecki, Boguslaw Buszewski
FOOD ANALYTICAL METHODS
(2019)
Article
Chemistry, Multidisciplinary
Ileana-Andreea Ratiu, Tomasz Ligor, Fernanda Monedeiro, Hossam Al-Suod, Victor Bocos-Bintintan, Jacek Szeliga, Marek Jackowski, Boguslaw Buszewski
STUDIA UNIVERSITATIS BABES-BOLYAI CHEMIA
(2019)
Article
Biochemical Research Methods
Maciej Milanowski, Fernanda Monedeiro, Michal Zloch, Ileana-Andreea Ratiu, Pawel Pomastowski, Tomasz Ligor, Bruno S. De Martinis, Boguslaw Buszewski
ANALYTICAL BIOCHEMISTRY
(2019)
Review
Chemistry, Analytical
Ileana-Andreea Ratiu, Victor Bocos-Bintintan, Fernanda Monedeiro, Maciej Milanowski, Tomasz Ligor, Boguslaw Buszewski
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Fernanda Monedeiro, Maciej Milanowski, Ileana-Andreea Ratiu, Hubert Zmyslowski, Tomasz Ligor, Boguslaw Buszewski
Article
Medicine, General & Internal
Fernanda Monedeiro, Pawel Pomastowski, Maciej Milanowski, Tomasz Ligor, Boguslaw Buszewski
JOURNAL OF CLINICAL MEDICINE
(2019)
Review
Chemistry, Analytical
Radik Mametov, Ileana-Andreea Ratiu, Fernanda Monedeiro, Tomasz Ligor, Boguslaw Buszewski
Summary: A chromatographic column is essential for gas-chromatographic analysis, with developments in technology providing endless possibilities for analysis using diverse matrices. This review article discusses the evolution and future trends of chromatographic columns, as well as theoretical relationships, concepts for column selection, and parameters for evaluating column efficiency. The early stages of column preparation to the development of modern GC capillary columns are also detailed.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Tomasz Ligor, Joanna Zawadzka, Grzegorz Straczynski, Rosa M. Gonzalez Paredes, Anna Wenda-Piesik, Ileana Andreea Ratiu, Marek Muszytowski
Summary: The study used headspace solid phase microextraction to extract volatile organic compounds from urine samples and identified different metabolic profiles between patients with glomerular diseases and healthy controls. The developed methodology offers the opportunity to examine the metabolic profile associated with glomerulopathy, with four compounds proposed as markers for glomerular diseases.
Article
Biochemistry & Molecular Biology
Fernanda Monedeiro, Maciej Monedeiro-Milanowski, Ileana-Andreea Ratiu, Beata Brozek, Tomasz Ligor, Boguslaw Buszewski
Summary: The study quantified 29 VOCs in breath samples from lung cancer, chronic obstructive pulmonary disease, and asthma patients, as well as investigated global VOC profiles. Results showed that VOCs in breath samples could serve as potential biomarkers of diseases, assisting in disease discrimination and classification.
Article
Multidisciplinary Sciences
Ileana Andreea Ratiu, Radik Mametov, Tomasz Ligor, Boguslaw Buszewski
Summary: VOCs are increasingly being explored for disease diagnosis due to their strategic advantages over classical methods. A new method for feces sampling using a Micro-Chamber/Thermal Extractor was developed, with extraction time, temperature and flow rate found to significantly impact results. Validation through correlation tests and Network analysis provided evidence for the efficacy of the developed model.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Tomasz Ligor, Przemyslaw Adamczyk, Tomasz Kowalkowski, Ileana Andreea Ratiu, Anna Wenda-Piesik, Boguslaw Buszewski
Summary: In this study, headspace solid phase microextraction (SPME) and gas chromatography time of flight mass spectrometry (GCxGC TOF MS) were used to analyze the volatile organic compounds (VOCs) in urine samples of bladder cancer patients and healthy individuals. The results showed that there were different VOC profiles between bladder cancer patients and healthy individuals. Several potential biomarkers were identified.
Article
Environmental Sciences
Daria Kosmalska, Katarzyna Janczak, Aneta Raszkowska-Kaczor, Andrzej Stasiek, Tomasz Ligor
Summary: This article focuses on the properties of polylactide (PLA), a biodegradable material, during the extrusion process. By adjusting factors such as temperature, structure of the plasticizing system, and rotational speed, improvements in mechanical properties of the final product can be achieved, while reducing energy consumption and raw material waste, thus benefiting the environment.
Meeting Abstract
Chemistry, Multidisciplinary
Jonathan Beauchamp, Agnieszka Smolinska, Robert van Vorstenbosch, Tomasz Ligor, Lena Schlund, Boguslaw Buszewski, Frederik-Jan van Schooten
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2019)