Review
Gastroenterology & Hepatology
Shiying Wu, Yongqiang Chen, Ziqi Chen, Fangtong Wei, Qingqing Zhou, Ping Li, Qing Gu
Summary: H. pylori colonization in the stomach induces inflammatory response and production of ROS and RNS, but the bacterium has developed strategies to counteract the harmful effects of ROS. However, the host's inability to eliminate H. pylori infection results in persistent ROS production, which may lead to chronic inflammation and gastric carcinogenesis.
Article
Environmental Sciences
Xiaole Wang, Jingwen Zhang, Chengbo Lu, Yu Liu, Xiao Yang, Kaixuan Hou, Zhongkun Du, Bing Li, Albert Juhasz, Lusheng Zhu
Summary: This study evaluated the toxicity of environmentally relevant concentrations of pyroxsulam to zebrafish embryos and adults, providing valuable data for assessing its effects on aquatic ecosystems.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Alain P. Gobert, Mohammad Asim, Thaddeus M. Smith, Kamery J. Williams, Daniel P. Barry, Margaret M. Allaman, Kara M. McNamara, Caroline V. Hawkins, Alberto G. Delgado, Shilin Zhao, M. Blanca Piazuelo, M. Kay Washington, Lori A. Coburn, John A. Rathmacher, Keith T. Wilson
Summary: This study found that isolevuglandins (isoLGs), formed from lipid peroxidation, covalently bind with amine-containing macromolecules in colonic epithelial cells of colorectal cancer (CRC) patients. The natural compound 2-hydroxybenzylamine (2-HOBA), a scavenger of electrophiles, was shown to reduce isoLG adduct levels, tumorigenesis, and oncogenic NRF2 activation in CRC models. In addition, 2-HOBA attenuated the growth of human CRC cells in animal models.
Article
Nutrition & Dietetics
Malgorzata M. Brzoska, Magdalena Kozlowska, Joanna Rogalska, Malgorzata Galazyn-Sidorczuk, Alicja Roszczenko, Nazar M. Smereczanski
Summary: This research showed that increasing zinc intake can alleviate oxidative stress and damage caused by cadmium in the brain. The interaction between zinc and cadmium can effectively prevent the imbalance in oxidative/antioxidative status and protect against injury to cellular macromolecules in the nervous system.
Article
Biochemistry & Molecular Biology
Neza Brezovec, Katja Perdan-Pirkmajer, Blaz Burja, Ziga Rotar, Josko Osredkar, Snezna Sodin-Semrl, Katja Lakota, Sasa Cucnik
Summary: The balance between reactive oxygen species and antioxidant defense is disrupted in oxidative stress. This study examined the oxidative balance in systemic sclerosis (SSc) patients and healthy controls, and found high levels of reactive oxidative metabolites (ROMs) in both groups. However, SSc patients had significantly higher total antioxidant capacity (TAC) and oxidative stress index, indicating an increased antioxidant capacity. Although there was no difference in lipid peroxidation or oxidative DNA damage, SSc patients had more leukocyte DNA breaks, especially those treated with immunosuppressives.
Article
Environmental Sciences
Ryan S. Babadi, Anne M. Riederer, Paul D. Sampson, Sheela Sathyanarayana, Terrance J. Kavanagh, Jennifer E. Krenz, Syam S. Andra, Seunghee Kim-Schulze, Karen L. Jansen, Elizabeth Torres, Adriana Perez, Lisa R. Younglove, Maria I. Tchong-French, Catherine J. Karr
Summary: Studies show a positive relationship between phthalate exposure and oxidative stress in children with asthma, indicating a potential adverse impact on asthma morbidity. Further research is needed to confirm these findings and better understand the role of phthalates in childhood asthma.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Biotechnology & Applied Microbiology
Rekha Jalandra, Nishu Dalal, Amit K. Yadav, Damini Verma, Minakshi Sharma, Rajeev Singh, Ajit Khosla, Anil Kumar, Pratima R. Solanki
Summary: TMAO, a metabolite derived from gut microbiota, has attracted attention for its potential role in colorectal cancer carcinogenesis, but lacks empirical mechanistic evidence. This review discusses possible mechanisms of TMAO in CRC, emphasizing the need for further mechanistic studies to solidify the link between TMAO and CRC causation.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Agricultural Engineering
Muhammad Ahmad, Ejaz Ahmad Waraich, Usman Zulfiqar, Aman Ullah, Muhammad Farooq
Summary: This study demonstrated that the application of thiourea can improve heat tolerance in camelina, increase seed yield, and protect plants from oxidative damage. Additionally, thiourea application was more effective at the reproductive stage, and genotype 618 showed higher tolerance to heat stress compared to genotype 611.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Yingya Zhao, Marina S. Nogueira, Ginger L. Milne, Xingyi Guo, Hui Cai, Qing Lan, Nathaniel Rothman, Qiuyin Cai, Yu-Tang Gao, Qingxia Chen, Xiao-Ou Shu, Gong Yang
Summary: The study found that miRNAs associated with F2-IsoP-M are enriched for various lipid peroxidation-related processes, and some miRNAs exhibited functional interactions with mRNAs involved in the regulation of beta-oxidation.
Article
Biochemistry & Molecular Biology
Karolina Janion, Joanna Katarzyna Strzelczyk, Katarzyna Weronika Walkiewicz, Krzysztof Biernacki, Angelika Copija, Elzbieta Szczepanska, Ewa Nowakowska-Zajdel
Summary: Oxidative stress is believed to have a significant impact on colorectal cancer. This study found that levels of MDA and TAS were significantly lower in CRC patients compared to the control group, while TOS levels were significantly higher. Furthermore, the study revealed a correlation between MDA levels and the location of the primary tumor and the left and right sides of the colon.
Article
Nutrition & Dietetics
Daniela Martini, Raul Dominguez-Perles, Alice Rosi, Michele Tassotti, Donato Angelino, Sonia Medina, Cristian Ricci, Alexandre Guy, Camille Oger, Letizia Gigliotti, Thierry Durand, Mirko Marino, Hans Gottfried-Genieser, Marisa Porrini, Monica Antonini, Alessandra Dei Cas, Riccardo C. Bonadonna, Federico Ferreres, Francesca Scazzina, Furio Brighenti, Patrizia Riso, Cristian Del Bo, Pedro Mena, Angel Gil-Izquierdo, Daniele Del Rio
Summary: The study investigated the effect of consuming different doses of coffee or cocoa-based products containing coffee on markers of DNA damage and lipid peroxidation in young healthy volunteers for one month. Overall, the results showed that consumption of these products did not significantly affect oxidative stress markers, except for a time effect on DNA strand breaks and some markers of lipid peroxidation. Further studies are needed to better explain the findings and understand the impact of different dosages on specific target groups.
Review
Biochemistry & Molecular Biology
Heshu Chen, Chenyu Wang, Zemin Liu, Xinmiao He, Wenjie Tang, Liuqin He, Yanzhong Feng, Di Liu, Yulong Yin, Tiejun Li
Summary: Ferroptosis is a novel type of non-apoptotic cell death that can be triggered by specific modulators. It has potential implications in preventing inflammatory storms and cancer development. Ferroptosis may mediate biological processes such as oxidative stress and iron overload to treat cancer.
Review
Biochemistry & Molecular Biology
Da-Young Lee, Moon-Young Song, Eun-Hee Kim
Summary: Colorectal cancer has a high prevalence in patients with inflammatory bowel disease, and oxidative stress is known to be one of the causes of inflammatory diseases and malignant disorders. The Nrf2/KEAP1 pathway is believed to protect cells from oxidative stress and inflammation. Phytochemicals may play a role in preventing or inhibiting colorectal cancer progression.
Article
Biochemistry & Molecular Biology
Miriam J. Kavec, Marketa Urbanova, Pavol Makovicky, Alena Opattova, Kristyna Tomasova, Michal Kroupa, Klara Kostovcikova, Anna Siskova, Nazila Navvabi, Michaela Schneiderova, Veronika Vymetalkova, Ludmila Vodickova, Pavel Vodicka
Summary: Oxidative stress, oxidative DNA damage, and its repair are closely related to the development of colorectal cancer, but cannot solely explain the onset of sporadic colorectal cancer. Other factors, especially the microenvironment, need further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Giulia Leanza, Caterina Conte, Francesca Cannata, Camilla Isgro, Alessandra Piccoli, Rocky Strollo, Carlo Cosimo Quattrocchi, Rocco Papalia, Vincenzo Denaro, Mauro Maccarrone, Nicola Napoli, Anna Maria Sardanelli
Summary: In this study, the oxidative stress states were compared between postmenopausal women with and without obesity. The results showed that women with obesity had doubled levels of oxidative stress markers compared to women of normal weight. The severity of oxidative stress was correlated with body mass index, visceral fat mass, and trunk fat percentage, but not with fasting glucose levels. These findings suggest that obesity and visceral fat increase oxidative stress in postmenopausal women, potentially increasing the risks of cardiometabolic and cancer diseases.
Article
Biochemistry & Molecular Biology
Wei Wang, Xin Li, Fan Wang, Xiang-Yu Sun
JOURNAL OF CELLULAR BIOCHEMISTRY
(2018)
Article
Oncology
Yupeng Liu, Yibaina Wang, Fulan Hu, Hongru Sun, Zuoming Zhang, Xuan Wang, Xiang Luo, Lin Zhu, Rong Huang, Yan Li, Guangxiao Li, Xia Li, Shangqun Lin, Fan Wang, Yanhong Liu, Jiesheng Rong, Huiping Yuan, Yashuang Zhao
Article
Oncology
Yanming Yu, Junde Zhou, Chen Gong, Zhiping Long, Jingshen Tian, Lin Zhu, Jing Li, Hongyuan Yu, Fan Wang, Yashuang Zhao
Article
Oncology
Weinan Xue, Jingwen Li, Fan Wang, Peng Han, Yanlong Liu, Binbin Cui
Article
Oncology
Ya-Nan Liang, Yu Liu, Letian Wang, Guodong Yao, Xiaobo Li, Xiangning Meng, Fan Wang, Ming Li, Dandan Tong, Jingshu Geng
Article
Medicine, Research & Experimental
Weinan Xue, Xiangxin Wu, Fan Wang, Peng Han, Binbin Cui
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Oncology
Nannan Zhang, Yanbo Chen, Shuo Li, Huihui Yin, Liangliang Li, Ming Shan, Zhiping Long, Jingshen Tian, Jing Li, Hongyuan Yu, Kun Xie, Zhen Wu, Volontovich Daria, Fan Wang, Yashuang Zhao
Article
Immunology
Hongsheng Liang, Yong Sun, Aili Gao, Nannan Zhang, Ying Jia, Shanshan Yang, Meng Na, Huailei Liu, Xingbo Cheng, Xiaofeng Fang, Wei Ma, Xiangtong Zhang, Fan Wang
INTERNATIONAL IMMUNOPHARMACOLOGY
(2019)
Article
Nutrition & Dietetics
Qingli Yu, Xiaohan Sun, Jiali Zhao, Lan Zhao, Yanfeng Chen, Lina Fan, Zixiang Li, Yongzhi Sun, Maoqing Wang, Fan Wang
NUTRITION & METABOLISM
(2019)
Article
Oncology
Fan Wang, Maoqing Wang, Huihui Yin, Zhiping Long, Lin Zhu, Huan Yu, Hongru Sun, Haoran Bi, Shuying Li, Yashuang Zhao, Xinshu Dong, Junde Zhou
Summary: The study found a correlation between plasma PGE(2) levels and CRC risk, and suggested personalized adjustment of NSAIDs doses based on PTGS2 genotypes and plasma PGE(2) levels.
EUROPEAN JOURNAL OF CANCER PREVENTION
(2021)
Review
Biotechnology & Applied Microbiology
Jingshen Tian, Weinan Xue, Huihui Yin, Nannan Zhang, Junde Zhou, Zhiping Long, Chengwei Wu, Zhengzi Liang, Kun Xie, Shuo Li, Liangliang Li, Zhen Wu, Volontovich Daria, Yashuang Zhao, Fan Wang, Maoqing Wang
ONCOTARGETS AND THERAPY
(2020)
Article
Oncology
Zhiping Long, Junde Zhou, Kun Xie, Zhen Wu, Huihui Yin, Volontovich Daria, Jingshen Tian, Nannan Zhang, Liangliang Li, Yashuang Zhao, Fan Wang, Maoqing Wang, Yunfu Cui
FRONTIERS IN ONCOLOGY
(2020)
Article
Food Science & Technology
Shuo Li, Chunyang Xi, Liangliang Li, Zhiping Long, Nannan Zhang, Huihui Yin, Kun Xie, Zhen Wu, Jingshen Tian, Fan Wang, Maoqing Wang
Summary: Oral vitamin D supplementation did not significantly reduce the risk of fractures, but Vitamin D-3 combined with calcium significantly reduced the incidence of fractures, particularly in females. An inverse relationship was found between the efficacy of fracture prevention and increased body mass index.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2021)
Review
Nutrition & Dietetics
Yi Wu, Maoqing Wang, Zhiping Long, Jingyu Ye, Yukun Cao, Bing Pei, Yu Gao, Yue Yu, Zhen Han, Fan Wang, Yashuang Zhao
Summary: Non-communicable diseases, particularly cardiovascular diseases and cancer, are significant causes of death. This study evaluates the relationship between red and processed meat intake and the risk of mortality, as well as the impact of physical activity on mortality risk. The findings suggest that engaging in physical activity can effectively reduce the risk of death associated with meat consumption.
Article
Cell Biology
Weinan Xue, Fan Wang, Peng Han, Yanlong Liu, Bomiao Zhang, Xinyue Gu, Yue Wang, Mingqi Li, Yashuang Zhao, Binbin Cui
