4.5 Article

Effects of curvature and cell-cell interaction on cell adhesion in microvessels

期刊

出版社

SPRINGER HEIDELBERG
DOI: 10.1007/s10237-010-0202-1

关键词

Cell adhesion; Lattice Boltzmann method; Curved microvessel

资金

  1. Research Grants Council of the Government of the HKSAR [PolyU 5238/08E]
  2. Hong Kong Polytechnic University
  3. US National Science Foundation [CBET 0754158]
  4. Div Of Chem, Bioeng, Env, & Transp Sys
  5. Directorate For Engineering [GRANTS:13737082, 0754158] Funding Source: National Science Foundation

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It has been found that both circulating blood cells and tumor cells are more easily adherent to curved microvessels than straight ones. This motivated us to investigate numerically the effect of the curvature of the curved vessel on cell adhesion. In this study, the fluid dynamics was carried out by the lattice Boltzmann method (LBM), and the cell dynamics was governed by the Newton's law of translation and rotation. The adhesive dynamics model involved the effect of receptor-ligand bonds between circulating cells and endothelial cells (ECs). It is found that the curved vessel would increase the simultaneous bond number, and the probability of cell adhesion is increased consequently. The interaction between traveling cells would also affect the cell adhesion significantly. For two-cell case, the simultaneous bond number of the rear cell is increased significantly, and the curvature of microvessel further enhances the probability of cell adhesion.

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