Article
Pharmacology & Pharmacy
Guang Zhong Liu, Wei Xu, Yan Xiang Zang, Qi Lou, Peng Zhou Hang, Qiang Gao, Hang Shi, Qi Yun Liu, Hong Wang, Xin Sun, Cheng Liu, Peng Zhang, Hua Dong Liu, Shao Hong Dong
Summary: The study revealed that Sirt3 was significantly down-regulated in AF patients and models, but restored by HL treatment. Sirt3 could regulate the acetylated modification of key metabolic enzymes, and increasing Sirt3 levels rescued AF-induced atrial metabolic remodeling.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Lucile Fossier, Mathieu Panel, Laura Butruille, Sarah Colombani, Lan Azria, Eloise Woitrain, Raphael Decoin, Angelo G. Torrente, Jerome Thireau, Alain Lacampagne, David Montaigne, Jeremy Fauconnier
Summary: This study revealed that impaired mitochondrial Ca2+ handling and MCUC activity contribute to atrial fibrillation in metabolic cardiomyopathy. Increased expression of MICUs subunits of MCUC was associated with impaired mitochondrial Ca2+ uptake in patients with MetS and HFS mice. The MCUC agonist kaempferol restored MCUC activity and prevented AF in HFS mice.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Review
Physiology
Yajun Yao, Mei Yang, Dishiwen Liu, Qingyan Zhao
Summary: Immune remodeling is a new direction for research and therapeutic strategies for atrial fibrillation (AF) as it has complex relationships with atrial electrical, structural, and neural remodeling. It may provide effective therapies for AF.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Olivia T. Ly, Hanna Chen, Grace E. Brown, Liang Hong, Xinge Wang, Yong Duk Han, Mahmud Arif Pavel, Arvind Sridhar, Mark Maienschein-Cline, Brandon Chalazan, Sang-Ging Ong, Khaled Abdelhady, Malek Massad, Lona Ernst Rizkallah, Jalees Rehman, Salman R. Khetani, Dawood Darbar
Summary: We successfully generated mature human induced pluripotent stem cell-derived atrial cardiomyocytes (iPSC-aCMs) using a combinatorial engineering approach. By comparing with the patient's own tissue, we revealed the underlying mechanism of the first non-ion channel gene, NPPA, that causes atrial fibrillation (AF). This maturation approach will contribute to the understanding of the molecular basis of heritable AF and the development of personalized therapies.
Article
Cardiac & Cardiovascular Systems
Christoph Beyer, Lyudmyla Tokarska, Markus Stuhlinger, Gudrun Feuchtner, Florian Hintringer, Sarah Honold, Lukas Fiedler, Marie-Sophie Schonbauer, Robert Schonbauer, Fabian Plank
Summary: Atrial wall thickness, epicardial fat volume, and attenuation are associated with AF recurrence in patients undergoing ablation therapy.
JACC-CARDIOVASCULAR IMAGING
(2021)
Article
Multidisciplinary Sciences
Sylvain Delaunay, Gloria Pascual, Bohai Feng, Kevin Klann, Mikaela Behm, Agnes Hotz-Wagenblatt, Karsten Richter, Karim Zaoui, Esther Herpel, Christian Munch, Sabine Dietmann, Jochen Hess, Salvador Aznar Benitah, Michaela Frye
Summary: The study reveals that the NSUN3-dependent RNA modifications of mitochondrial mRNA can impact metabolic plasticity, thus affecting the metastatic potential of cancer cells, providing new therapeutic targets for combating cancer metastasis.
Article
Multidisciplinary Sciences
Kazuya Nishio, Tomoyuki Kawarasaki, Yuki Sugiura, Shunsuke Matsumoto, Ayano Konoshima, Yuki Takano, Mayuko Hayashi, Fumihiko Okumura, Takumi Kamura, Tsunehiro Mizushima, Kunio Nakatsukasa
Summary: Deficiencies in mitochondrial protein import are associated with diseases, but it is unclear how accumulation of non-imported mitochondrial proteins causes cell dysfunction. This study showed that non-imported citrate synthase is targeted for proteasomal degradation. Accumulation of non-imported citrate synthase caused ectopic citrate synthesis, leading to metabolic imbalance and growth defect. This study highlights the importance of mitochondrial import and its failure in cellular metabolism.
Article
Cardiac & Cardiovascular Systems
Ryo Nishinarita, Shinichi Niwano, Hiroe Niwano, Hironori Nakamura, Daiki Saito, Tetsuro Sato, Gen Matsuura, Yuki Arakawa, Shuhei Kobayashi, Yuki Shirakawa, Ai Horiguchi, Naruya Ishizue, Tazuru Igarashi, Tomoharu Yoshizawa, Jun Oikawa, Yoshinobu Hara, Takafumi Katsumura, Jun Kishihara, Akira Satoh, Hidehira Fukaya, Hiroyuki Sakagami, Junya Ako
Summary: This study found that the SGLT2 inhibitor canagliflozin may be beneficial for preventing atrial fibrillation and suppressing atrial remodeling, by reducing atrial effective refractory period, decreasing conduction velocity, and inhibiting the inducibility of AF.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Yoshiko Murakata, Fumi Yamagami, Nobuyuki Murakoshi, DongZhu Xu, Zhonghu Song, Siqi Li, Yuta Okabe, Kazuhiro Aonuma, ZiXun Yuan, Haruka Mori, Kazutaka Aonuma, Kazuko Tajiri, Masaki Ieda
Summary: Inflammatory atrial cardiomyopathy can lead to atrial fibrillation, characterized by enlarged atria, infiltration of inflammatory cells, and fibrosis. These changes increase susceptibility to arrhythmias by affecting electrical conduction, genetic factors, and autonomic regulation. Therefore, reducing inflammation is important in preventing atrial fibrillation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Xin Guan, Qiyang Yan, Dandan Wang, Guocheng Du, Jingwen Zhou
Summary: This study investigates the effects of IGF-1 signaling on mitochondrial remodeling during myogenic differentiation, and identifies key mediators of IGF-1-induced mitochondrial biogenesis and mitophagy. IGF-1 signaling stimulates mitochondrial biogenesis by increasing mitochondrial DNA copy number and the expression of related genes. Additionally, IGF-1 treatment significantly enhances mitophagy levels in differentiating myoblasts, contributing to mitochondrial turnover.
Article
Medicine, General & Internal
Nathalie Noirclerc, Olivier Huttin, Christian de Chillou, Christine Selton-Suty, Laura Fillipetti, Jean Marc Sellal, Erwan Bozec, Erwan Donal, Zohra Lamiral, Masatake Kobayashi, Joao Pedro Ferreira, Patrick Rossignol, Nicolas Girerd
Summary: The study found that patients with paroxysmal atrial fibrillation exhibit early cardiac remodeling, characterized by increased left ventricular mass and left atrial enlargement. Although less than 10% of patients show diastolic dysfunction, there is a significant association with atrial fibrillation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Megan Watts, Gopi K. Kolluru, Parinita Dherange, Sibile Pardue, Man Si, Xinggui Shen, Krystle Trosclair, John Glawe, Zaki Al-Yafeai, Mazen Iqbal, Brenna H. Pearson, Kathryn A. Hamilton, A. Wayne Orr, Edward Glasscock, Christopher G. Kevil, Paari Dominic
Summary: Oxidative stress is a driving factor in the pathogenesis of atrial fibrillation (AF), with hydrogen sulfide (H2S) playing an important role in regulating electrical remodeling and susceptibility to AF. Patients with AF had significantly lower plasma sulfide levels, and those with persistent AF had even lower levels compared to paroxysmal AF patients. Additionally, CSE knockout mice showed decreased atrial sulfide levels, increased atrial superoxide levels, and enhanced propensity for induced persistent AF compared to wild type mice.
Review
Cardiac & Cardiovascular Systems
Yi Ching Chen, Aleksandr Voskoboinik, Andre La Gerche, Thomas H. Marwick, Julie R. McMullen
Summary: Studies have extensively researched the differences between physiological and pathological ventricular hypertrophy, while the differences between physiological and pathological atrial enlargement remain poorly understood.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yunhua Peng, Huadong Liu, Jiankang Liu, Jiangang Long
Summary: Mitochondria play a crucial role in the initiation and development of tumor cells, with metabolic proteins serving as key mediators in tumorigenesis. Understanding mitochondria-related post-translational modifications is important for the future of cancer treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Wenjin Cai, Jinglun Zhang, Yiqian Yu, Yueqi Ni, Yan Wei, Yihong Cheng, Litian Han, Leyi Xiao, Xiaoxin Ma, Hongjiang Wei, Yaoting Ji, Yufeng Zhang
Summary: Mitochondrial transfer from macrophages to mesenchymal stem cells regulates bone homeostasis, and abnormal transfer under osteoporotic conditions leads to metabolic remodeling in stem cells.