K-RASmutation in the screening, prognosis and treatment of cancer

Sensitive and quantitative detection of KRAS2 gene mutations in pancreatic duct juice differentiates patients with pancreatic cancer from chronic pancreatitis, potential for early detection

(2010) Chanjuan Shi et al.   CANCER BIOLOGY & THERAPY

Epidermal Growth Factor Receptor-Related Tumor Markers and Clinical Outcomes with Erlotinib in Non-small Cell Lung Cancer: An Analysis of Patients from German Centers in the TRUST Study

(2010) Claus-Peter Schneider et al.   Journal of Thoracic Oncology

Tissue Factor Expression in Non-small Cell Lung Cancer: Relationship with Vascular Endothelial Growth Factor Expression, Microvascular Density, and K-ras Mutation

(2010) Sandra Regina et al.   Journal of Thoracic Oncology

KRAS Mutation Testing in Colorectal Cancer

(2009) Thomas P. Plesec et al.   ADVANCES IN ANATOMIC PATHOLOGY

Results of a Phase I Trial of 12 Patients With Locally Advanced Pancreatic Carcinoma Combining Gefitinib, Paclitaxel, and 3-Dimensional Conformal Radiation

(2009) Christine C. Olsen et al.   AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS

Removal of High-Molecular-Weight DNA by Carboxylated Magnetic Beads Enhances the Detection of MutatedK-rasDNA in Urine

(2009) Ying-Hsiu Su et al.   Annals of the New York Academy of Sciences

A novel mutant allele specific amplification and electrochemiluminescence method for the detection of point mutation in clinical samples

(2009) Debin Zhu et al.   BIOSENSORS & BIOELECTRONICS

Fast simultaneous detection of K-RASmutations in colorectal cancer

(2009) Ya-Sian Chang et al.   BMC CANCER

Treatment in advanced colorectal cancer: what, when and how?

(2009) I Chau et al.   BRITISH JOURNAL OF CANCER

Detection of K-Ras mutations in tumour samples of patients with non-small cell lung cancer using PNA-mediated PCR clamping

(2009) M Beau-Faller et al.   BRITISH JOURNAL OF CANCER

Assessment of K-rasmutation

(2009) Yixing Jiang et al.   CANCER

Genotyping of K-ras codons 12 and 13 mutations in colorectal cancer by capillary electrophoresis

(2009) Yen-Ling Chen et al.   JOURNAL OF CHROMATOGRAPHY A

The Marriage of Growth Factor Inhibitors and Chemotherapy: Bliss or Bust?

(2009) Stephen Staal et al.   JOURNAL OF CLINICAL ONCOLOGY

American Society of Clinical Oncology Provisional Clinical Opinion: Testing forKRASGene Mutations in Patients With Metastatic Colorectal Carcinoma to Predict Response to Anti–Epidermal Growth Factor Receptor Monoclonal Antibody Therapy

(2009) Carmen J. Allegra et al.   JOURNAL OF CLINICAL ONCOLOGY

KRAS Mutations and Sensitivity to Epidermal Growth Factor Receptor Inhibitors in Colorectal Cancer: Practical Application of Patient Selection

(2009) Antonio Jimeno et al.   JOURNAL OF CLINICAL ONCOLOGY

Chemotherapy, Bevacizumab, and Cetuximab in Metastatic Colorectal Cancer

(2009) Jolien Tol et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cetuximab and Chemotherapy as Initial Treatment for Metastatic Colorectal Cancer

(2009) Eric Van Cutsem et al.   NEW ENGLAND JOURNAL OF MEDICINE

K-ras Mutations in Circulating DNA From Pancreatic and Lung Cancers

(2009) Paolo Magistrelli et al.   PANCREAS

Integration and use of biomarkers in drug development, regulation and clinical practice: a US regulatory perspective

(2008) Shashi Amur et al.   Biomarkers in Medicine

Clinical interest of KRAS mutation detection in blood for anti-EGFR therapies in metastatic colorectal cancer

(2008) F Di Fiore et al.   BRITISH JOURNAL OF CANCER

Quantitative and qualitative characterization of plasma DNA identifies primary and recurrent colorectal cancer

(2008) M. Frattini et al.   CANCER LETTERS

Frequency and Distinctive Spectrum of KRAS Mutations in Never Smokers with Lung Adenocarcinoma

(2008) G. J. Riely et al.   CLINICAL CANCER RESEARCH

Association of K-ras Mutational Status and Clinical Outcomes in Patients with Metastatic Colorectal Cancer Receiving Panitumumab Alone

(2008) Daniel J. Freeman et al.   Clinical Colorectal Cancer

Analysis of Mutations in DNA Isolated From Plasma and Stool of Colorectal Cancer Patients

(2008) Frank Diehl et al.   GASTROENTEROLOGY

Molecular Characteristics of Bronchioloalveolar Carcinoma and Adenocarcinoma, Bronchioloalveolar Carcinoma Subtype, Predict Response to Erlotinib

(2008) Vincent A. Miller et al.   JOURNAL OF CLINICAL ONCOLOGY

Mutations ofKRASandBRAFin Primary and Matched Metastatic Sites of Colorectal Cancer

(2008) Salvatore Artale et al.   JOURNAL OF CLINICAL ONCOLOGY

Wild-TypeKRASIs Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer

(2008) Rafael G. Amado et al.   JOURNAL OF CLINICAL ONCOLOGY

A Randomized Phase IIIB Trial of Chemotherapy, Bevacizumab, and Panitumumab Compared With Chemotherapy and Bevacizumab Alone for Metastatic Colorectal Cancer

(2008) J. Randolph Hecht et al.   JOURNAL OF CLINICAL ONCOLOGY

Fluorouracil, Leucovorin, and Oxaliplatin With and Without Cetuximab in the First-Line Treatment of Metastatic Colorectal Cancer

(2008) Carsten Bokemeyer et al.   JOURNAL OF CLINICAL ONCOLOGY

Assessment of somatic k-RAS mutations as a mechanism associated with resistance to EGFR-targeted agents: a systematic review and meta-analysis of studies in advanced non-small-cell lung cancer and metastatic colorectal cancer

(2008) Helena Linardou et al.   LANCET ONCOLOGY

Many different tumor types have polyclonal tumor origin: Evidence and implications

(2008) B PARSONS   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Circulating mutant DNA to assess tumor dynamics

(2008) Frank Diehl et al.   NATURE MEDICINE

Replacing PCR with COLD-PCR enriches variant DNA sequences and redefines the sensitivity of genetic testing

(2008) Jin Li et al.   NATURE MEDICINE

EGFR Antagonists in Cancer Treatment

(2008) Fortunato Ciardiello et al.   NEW ENGLAND JOURNAL OF MEDICINE

K-rasMutations and Benefit from Cetuximab in Advanced Colorectal Cancer

(2008) Christos S. Karapetis et al.   NEW ENGLAND JOURNAL OF MEDICINE

KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program

(2008) J. H. J. M. van Krieken et al.   VIRCHOWS ARCHIV