Article
Biology
Esraa M. Seliem, Mohamed E. Azab, Randa S. Ismail, Abeer A. Nafeaa, Badriyah S. Alotaibi, Walaa A. Negm
Summary: This study investigates the effects of Coffea arabica or green coffee bean extract (GCBE) on obesity and its associated disorders. GCBE administration has been shown to decrease body and organ weights, improve serum biochemical parameters, and reduce adipocyte hypertrophy. GCBE also enhances insulin resistance and reduces inflammation. These findings suggest that GCBE may be a natural supplement for preventing and treating obesity and its related health issues.
Review
Biochemistry & Molecular Biology
Daniela Dadej, Ewelina Szczepanek-Parulska, Marek Ruchala
Summary: Signalling between different tissues plays a significant role in the development of metabolic disorders, particularly the interaction between liver-derived hepatokines and adipokines. The thyroid hormone is crucial for basal metabolic rate and lipid metabolism, and its dysfunction contributes to metabolic disorders. This review discusses the interplay between adipokines and thyroid hormones, shedding light on the mechanisms underlying atherosclerosis, cardiovascular complications, obesity, insulin resistance, and diabetes associated with thyroid dysfunction. Clinical findings on these cytokines in thyroid disorders are also summarized.
Review
Nutrition & Dietetics
Hamdan Z. Hamdan, Tasneem Ali, Ishag Adam
Summary: This systematic review and meta-analysis found a significant association between higher levels of retinol-binding protein 4 (RBP4) and the risk of preeclampsia. More longitudinal studies are needed to further understand the association and dynamics of RBP4 in preeclampsia cases.
Review
Medicine, General & Internal
Hangkai Huang, Chengfu Xu
Summary: Nonalcoholic fatty liver disease (NAFLD) is becoming more common as the global economy grows. Retinol-binding protein-4 (RBP4) has been found to be related to various metabolic diseases. However, observational studies on the association between serum RBP4 level and NAFLD prevalence have shown contradictory results. Further research should focus on the predictive value of RBP4 in NAFLD development and its potential as a therapeutic target.
CHINESE MEDICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Nevin Fazlioglu, Pelin Uysal, Sinem Durmus, Sibel Yurt, Remise Gelisgen, Hafize Uzun
Summary: This study investigated the relationship between plasma irisin, RBP-4, and adiponectin levels and the severity of OSAS. The results showed that these biomarkers were associated with the disease and could be used for diagnosis in the absence of polysomnography. Patients with an AHI score greater than thirty should be closely monitored for metabolic abnormalities.
Review
Medicine, General & Internal
Wenhao Lu, Wenjie Feng, Jieyu Lai, Dongliang Yuan, Wenfeng Xiao, Yusheng Li
Summary: Sarcopenia is an age-related disease characterized by decreases in muscle mass, strength, and function, and an increase in body fat content, particularly visceral fat. Adipose tissue secretes adipokines, which have regulatory effects on muscle. For example, high levels of leptin decrease muscle function, while adiponectin inhibits muscle atrophy-related genes to prevent muscle mass loss. This article discusses the effects of adipokines such as leptin, adiponectin, resistin, mucin, and lipocalin-2 on muscle and their importance in understanding sarcopenia development.
CHINESE MEDICAL JOURNAL
(2023)
Article
Endocrinology & Metabolism
Jiali Xiang, Huajie Dai, Yanan Hou, Qi Wang, Tiange Wang, Mian Li, Zhiyun Zhao, Jieli Lu, Meng Dai, Di Zhang, Yu Xu, Guang Ning, Weiqing Wang, Jiqiu Wang, Yufang Bi, Min Xu
Summary: This study aimed to investigate the association of circulating RBP4 levels with long-term cardiometabolic risk profiles, taking into account sex differences. The results showed that higher RBP4 levels were associated with increased adiposity and deteriorated glucolipid profile. The association differed between men and women regarding 2-h post-loading glucose.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Rong Huang, Xinxiu Bai, Xueyan Li, Xiaohui Wang, Lina Zhao
Summary: Pancreatic beta-cell dysfunction in type 2 diabetes is influenced by elevated levels of retinol-binding protein 4 (RBP4), which directly suppresses insulin synthesis through the STRA6 pathway. Lowering circulating RBP4 levels could potentially restore beta-cell function and improve hyperglycemia in diabetic mice.
Article
Endocrinology & Metabolism
Delong Chen, Yuxuan Zhang, Abuduwufuer Yidilisi, Yi Xu, Qichao Dong, Jun Jiang
Summary: This study used a 2-sample Mendelian randomization approach to investigate the causal effects of circulating adipokines on cardiovascular disease risk. The findings suggest a causal association between resistin and atrial fibrillation, potentially mediated through blood pressure, and potential causal associations between chemerin and coronary artery disease, as well as retinol binding protein 4 and heart failure.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Chemistry, Medicinal
Noheul Kim, Ronny Priefer
Summary: RBP4 is associated with various diseases and metabolic syndromes, and the development of RBP4 antagonists and protein synthesis inhibitors may have therapeutic potential.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
J. N. Lopez-Canoa, M. Couselo-Seijas, A. Baluja, L. Gonzalez-Melchor, A. Rozados, V Llorente-Cortes, D. de Gonzalo-Calvo, J. M. Guerra, D. Vilades, R. Leta, J. L. Martinez-Sande, F. J. Garcia-Seara, X. A. Fernandez-Lopez, J. R. Gonzalez-Juanatey, S. Eiras, M. Rodriguez-Manero
Summary: The study found sex-based differences in FABP4 and leptin levels in relation to AF burden, with higher levels in women. These adipokines are associated with oxidative stress, inflammatory, and autonomic indirect markers, suggesting a potential role in perpetuating AF.
Article
Endocrinology & Metabolism
Mai Kiya, Yoshifumi Tamura, Kageumi Takeno, Yuki Someya, Saori Kakehi, Motonori Sato, Nozomu Yamasaki, Satoshi Kadowaki, Ruriko Suzuki, Yasuhiko Furukawa, Daisuke Sugimoto, Hideyoshi Kaga, Takashi Funayama, Miho Nishitani-Yokoyama, Kazunori Shimada, Hiroyuki Daida, Shigeki Aoki, Hiroaki Satoh, Ryuzo Kawamori, Hirotaka Watada
Summary: In nonobese Japanese men, high ATIS group showed no association between AN level and metabolic characteristics, whereas the low ATIS group exhibited reduced muscle insulin sensitivity and multiple metabolic abnormalities such as fatty liver and dyslipidemia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biology
Hajnalka Lorincz, Imre Csige, Mariann Harangi, Anita Szentpeteri, Ildiko Seres, Zoltan Szabo, Gyorgy Paragh, Sandor Somodi
Summary: The study revealed that serum fetuin-A and RBP4 concentrations were lower in morbid obese non-diabetic patients compared to controls, with a positive correlation between the two proteins. Fetuin-A showed positive correlations with HDL-C and large HDL subfractions, while RBP4 correlated positively with HDL-C, apoAI, and various HDL subfractions.
Article
Endocrinology & Metabolism
Fuqiang Liu, Ronghuai Zhang, Wei Zhang, Ling Zhu, Qi Yu, Zhongwei Liu, Yong Zhang, Shuo Pan, Yang Wang, Chao Chu, Li Hu, Qingyu Wang, Jiadong Yu, Jianjun Mu, Junkui Wang
Summary: High salt intake increases serum RBP4 levels in healthy individuals, while potassium supplementation reverses this effect. Furthermore, RBP4 levels are positively correlated with 24-hour urinary sodium excretion and negatively correlated with potassium excretion.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Article
Geriatrics & Gerontology
Chen-Lu Chang, Yan-Ru Li, Zhi-Yue Wang, Mei-Lin Li, Kai-Yue Jia, Hui-Xian Sun, Quan Wang, Can Zhao, Xiang Lu, Wei Gao
Summary: This study evaluated the association between serum RBP4 level and sarcopenia in older adults. The results showed a positive correlation between serum RBP4 level and the risk and severity of sarcopenia, indicating its potential as a biomarker for screening and evaluation of sarcopenia.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Medicine, Research & Experimental
Lingling Shu, Ling Zhong, Yang Xiao, Xiaoping Wu, Yang Liu, Xue Jiang, Tao Tang, RubyLaiChong Hoo, Zhiguang Zhou, Aimin Xu
Review
Endocrinology & Metabolism
Leiluo Geng, Karen S. L. Lam, Aimin Xu
NATURE REVIEWS ENDOCRINOLOGY
(2020)
Article
Biology
Yiwei Zhang, Handi Cao, Jie Chen, Yuanxin Li, Aimin Xu, Yu Wang
Summary: This study demonstrates the importance of adiponectin in the selection and development of T lymphocytes within thymic nurse cell complexes. Adiponectin-expressing regulatory T-cells (Treg) have the potential to improve glucose metabolism in obese mice and inhibit mammary tumor growth, suggesting them as a promising therapeutic agent against obesity-related metabolic and cancer diseases.
COMMUNICATIONS BIOLOGY
(2021)
Editorial Material
Endocrinology & Metabolism
Ranyao Yang, Aimin Xu, Alexei Kharitonenkov
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Chi Ho Lee, Andy Ka Chun Kan, David Tak Wai Lui, Carol Ho Yi Fong, Darren Shing Hei Chan, Michele Mae Ann Yuen, Wing Sun Chow, Yu Cho Woo, Aimin Xu, Karen Siu Ling Lam
Summary: This study found that circulating Adipocyte fatty acid-binding protein (AFABP) levels were associated with incident heart failure (HF) hospitalization in type 2 diabetes. Additionally, the use of sodium glucose co-transporter 2 inhibitors (SGLT2i) was shown to lower the risk of HF in these patients.
Review
Medicine, Research & Experimental
Kailash Singh, Bernard M. Y. Cheung, Aimin Xu
Summary: This study evaluated the diagnostic value of blood biomarkers for Alzheimer's (AD) and Parkinson's diseases (PD), identifying P-tau181, T-tau and Nfl as promising blood biomarkers for AD diagnosis. The raised levels of Nfl in AD cohorts and the significant increases in P-tau181 and T-tau in AD cohorts suggest the potential for using these biomarkers in noninvasive detection methods for AD and PD.
BIOMARKERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Kelvin Ka Lok Wu, KeKao Long, Huige Lin, Parco Ming Fai Siu, Ruby Lai Chong Hoo, Dewei Ye, Aimin Xu, Kenneth King Yip Cheng
Summary: The study reveals that the early endosomal APPL1-Rab5 axis helps remove damaged mitochondria and restricts inflammasome response in macrophages, mitigating inflammatory diseases.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Howell Leung, Xiaoxue Long, Yueqiong Ni, Lingling Qian, Emmanouil Nychas, Sara Leal Siliceo, Dennis Pohl, Kati Hanhineva, Yan Liu, Aimin Xu, Henrik B. Nielsen, Eugeni Belda, Karine Clement, Rohit Loomba, Huating Li, Weiping Jia, Gianni Panagiotou
Summary: A growing body of evidence suggests that the gut microbiota plays a role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). This study found that machine learning models integrating microbial signatures were able to accurately classify individuals based on their NAFLD status and liver fat accumulation, outperforming other clinical models. These findings raise the possibility of using gut microbiota for early clinical warning of NAFLD development.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Candela Diaz-Canestro, Brandon Pentz, Arshia Sehgal, Ranyao Yang, Aimin Xu, David Montero
Summary: Recent evidence suggests a link between lean body mass (LBM) and cardiovascular capacity in women. This study found that leg and arm LBM were positively associated with cardiac dimensions, ventricular relaxation, and vascular resistance in women, but not in men.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Juanying Zhen, Shuyun Liu, Ryan Yan Lam Kam, Guoru Zhao, Hao Peng, Jianguo Liang, Aimin Xu, Chao Li, Lijie Ren, Jun Wu, Bernard Man Yung Cheung
Summary: We aimed to investigate the relationship of B2M, cystatin C, and LCN-2 with stroke risk in a general Chinese population. Elevated levels of serum B2M, cystatin C, and LCN-2 were significantly associated with stroke risk. These biomarkers may serve as useful tools for clinicians to assess stroke risk.
ANNALS OF MEDICINE
(2023)
Article
Endocrinology & Metabolism
Chi-Ho Lee, David Tak-Wai Lui, Chloe Yu-Yan Cheung, Carol Ho-Yi Fong, Michele Mae-Ann Yuen, Yu-Cho Woo, Wing-Sun Chow, Ian Yat-Hin Wong, Aimin Xu, Karen Siu-Ling Lam
Summary: This study evaluated the associations of three diabetes-related biomarkers (AFABP, FGF21, and PEDF) with the development of sight-threatening diabetic retinopathy (STDR). The results showed that serum AFABP level was independently associated with incident STDR and its addition to a clinical model improved the prediction of STDR among participants without baseline retinopathy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Transplantation
Chi-Ho Lee, David Tak-Wai Lui, Chloe Yu-Yan Cheung, Carol Ho-Yi Fong, Michele Mae-Ann Yuen, Wing-Sun Chow, Aimin Xu, Karen Siu-Ling Lam
Summary: This study aimed to investigate the association between serum TSP2 level and kidney function decline in patients with type 2 diabetes. The results showed that serum TSP2 level was independently associated with incident eGFR decline and could predict a rapidly declining trajectory. This finding is of great importance for the renal health management of patients with diabetes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Kangmin Yang, Srividya Velagapudi, Alexander Akhmedov, Simon Kraler, Tetiana Lapikova-Bryhinska, Martin O. Schmiady, Xiaoping Wu, Leiluo Geng, Giovanni G. Camici, Aimin Xu, Thomas F. Luscher
Summary: This study aimed to investigate the therapeutic potential of chronic recombinant murine SIRT1 (rmSIRT1) supplementation to alleviate endothelial and vascular dysfunction in diabetic mice. The results showed that arterial SIRT1 levels were significantly reduced in diabetic conditions, while rmSIRT1 supplementation restored SIRT1 levels and improved endothelial function and vascular compliance. The study suggests that SIRT1 supplementation may represent a novel therapeutic strategy to prevent and treat diabetic vascular disease by enhancing eNOS activity and suppressing NOX-related oxidative stress.
CARDIOVASCULAR RESEARCH
(2023)
Article
Primary Health Care
Juanying Zhen, Shuyun Liu, Guoru Zhao, Hao Peng, Aimin Xu, Chao Li, Jun Wu, Bernard Man Yung Cheung
Summary: This study investigates the relationship between lifestyle and hypertension in a Chinese population and finds that a healthy lifestyle score is inversely related to the risk of hypertension. This highlights the importance of addressing lifestyle to reduce the risk of hypertension.
Article
Multidisciplinary Sciences
Baile Wang, Huige Lin, Xiaomu Li, Wenqi Lu, Jae Bum Kim, Aimin Xu, Kenneth K. Y. Cheng
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
