期刊
BIOMARKERS
卷 19, 期 8, 页码 667-673出版社
INFORMA HEALTHCARE
DOI: 10.3109/1354750X.2014.977951
关键词
Biomarker panel; early detection; gastric cancer; serum; unsaturated free fatty acids
资金
- National Natural Science Foundation of China [91029701]
Changes in the levels of free fatty acids (FFAs) are closely associated with physiological status. Serum levels of C-16:1, C-18:3, C-18:2, C-18:1, C-20:4, and C-22:6 in 164 gastric cancer (GC) patients and 111 benign gastric disease (BGD) patients were significantly decreased compared with 252 healthy controls. Receiver operating characteristic analysis showed that the biomarker panel including C-16:1, C-18:3, C-18:2, C-20:4, and C-22:6 presents a high diagnostic ability to differentiate early-stage GC patients from healthy controls plus BGD patients, with a sensitivity of 80.6% and a specificity of 72.7%.
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