期刊
BIOMARKERS
卷 19, 期 4, 页码 287-290出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2014.908954
关键词
Diagnosis; interleukin-17; non-small cell lung cancer; prognosis
资金
- Twelve-Five Plan the Major Program of Nanjing Medical Science and Technique Development Foundation (Molecular Mechanism Study on Metastasis and Clinical Efficacy Prediction of Non-small Cell Lung Cancer)
Objective: The aim of this study was to explore the clinical role of serum interleukin (IL)-17 in patients with non-small-cell lung cancer (NSCLC). Materials and method: Serum specimens from 128 patients with NSCLC and 60 healthy controls were collected. The concentrations of IL-17 were measured using enzyme-linked immunosorbent assay. Results: Serum IL-17 levels were higher in the NSCLC group in comparison with the control group (p<0.01). With a cut-off value of 16 pg/ml, IL-17 showed a good diagnostic performance for NSCLC. Multivariate survival analysis indicated that IL-17 was an independent prognostic factor in NSCLC. Conclusion: Measurement of IL-17 might be a useful diagnostic and prognostic value for patients with NSCLC.
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