Article
Medicine, General & Internal
Guadalupe Tabernero, Moises Pescador, Elena Ruiz Ferreras, Ana I. Morales, Marta Prieto
Summary: Kidney transplantation is the most effective treatment for end-stage chronic kidney disease. The study focused on early kidney damage biomarkers (NAG, NGAL, and KIM-1) to predict complications and improve graft survival rates. Urinary NAG, NGAL, and KIM-1 levels were analyzed in 70 kidney transplant patients over the first week post-transplantation. The study found correlations between these biomarkers and delayed graft function, as well as renal function stabilisation time.
Article
Medicine, General & Internal
Yingqun Chen, Jinbin Wu, Zihan Yin, Xuwei Lin, Weixing Zhang
Summary: This study aimed to explore the clinical value of combined detection of multiple biomarkers in serum and urine in evaluating the treatment effect of sepsis-induced acute kidney injury. The results showed that CRRT standardized treatment can significantly reduce the levels of several biomarkers in serum and urine, and the combined detection of these biomarkers can serve as important indicators for evaluating sepsis-induced acute kidney injury.
ACTA MEDICA MEDITERRANEA
(2022)
Article
Clinical Neurology
Zhuo Chen, Tianli Cao, Xingju Zhong, Yong Wu, Wei Fu, Chaoli Fan, Yu Jiang, Qi Zhou, Jie Peng, Jieyu Liao, Zhike You, Xin Yi, Jingyu Tan
Summary: This study aimed to investigate the utility of NT-1 as a biomarker for assessing the risk of early neurological deterioration after ischemic stroke. The results showed that decreased NT-1 levels were significantly associated with a higher risk of neurological deterioration.
FRONTIERS IN NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Karol Tejchman, Adam Nowacki, Katarzyna Kotfis, Edyta Skwirczynska, Maciej Kotowski, Labib Zair, Marek Ostrowski, Jerzy Sienko
Summary: Analysis of biomarkers during reperfusion of transplanted kidneys from brain dead donors showed that kidneys preserved with hypothermic machine perfusion had lower relative increase of certain biomarkers and better kidney function compared to those preserved with static cold storage. The long-term beneficial impact of hypothermic machine perfusion on transplanted kidneys may be due to the early modified proceedings and intensity of ischemia-reperfusion injury.
Article
Biochemistry & Molecular Biology
Cristina Cuesta, Isabel Fuentes-Calvo, Sandra M. Sancho-Martinez, Floris A. Valentijn, Annette Duwel, Omar A. Hidalgo-Thomas, Consuelo Agueros-Blanco, Adalberto Benito-Hernandez, Maria A. Ramos-Barron, Carlos Gomez-Alamillo, Manuel Arias, Tri Q. Nguyen, Roel Goldschmeding, Carlos Martinez-Salgado, Francisco J. Lopez-Hernandez
Summary: After acute kidney injury, despite the normalization of standard markers of glomerular filtration and tubular function, the degree of persistent histological findings of tissue repair correlates with renal expression and urinary levels of KIM-1 in rats. Additionally, KIM-1 is elevated in the urine of a significant number of patients apparently recovered from AKI. This study suggests a potential utility of urinary KIM-1 in early and subclinical diagnosis of renal damage, as well as a new application in non-invasive follow-up of renal repair after AKI.
Article
Biochemistry & Molecular Biology
Rudite Lagzdina, Maija Rumaka, Gita Gersone, Peteris Tretjakovs
Summary: This study examines the effects of acute aerobic exercise on the levels of circulating IL-8 and MCP-1, and their associations with body composition and energy metabolism. The results show that there are positive correlations between pre-exercise IL-8 and body mass, waist circumference, and lean body mass in men, and between pre-exercise MCP-1 and RMR in women. The exercise led to an increase in IL-8 and a decrease in MCP-1 levels. In men, the increase in post-exercise IL-8 is associated with higher walking energy expenditure, while in women, the increase in post-exercise MCP-1 is associated with lower RMR and running energy expenditure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Felix S. Seibert, Maximilian Sitz, Juergen Passfall, Martin Haesner, Peter Laschinski, Martin Buhl, Frederic Bauer, Benjamin Rohn, Nina Babel, Timm H. Westhoff
Summary: The study showed that urinary calprotectin and NGAL concentrations significantly differed between CKD patients and healthy controls, but these biomarkers did not have diagnostic value in differentiating primarily inflammatory from non-inflammatory etiologies of CKD.
Article
Chemistry, Medicinal
Mahmoud Elshal, Marwa E. Abdelmageed
Summary: The study demonstrates that diacerein can prevent or reverse acetaminophen-induced hepatotoxicity in mice, indicating its potential clinical utility as a repurposed drug.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kinga Musial, Jakub Stojanowski, Justyna Miskiewicz-Bujna, Krzysztof Kalwak, Marek Ussowicz
Summary: This study assessed the serum concentrations of KIM-1, IL-18, and NGAL in children undergoing HSCT and their usefulness as predictors of kidney damage. The results showed that serum KIM-1, IL-18, and NGAL concentrations before HSCT can serve as markers of renal dysfunction after the procedure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Laura Ziegon, Martin Schlegel
Summary: Netrin-1 plays a crucial role in various biological processes, including cell adhesion, migration, proliferation, and survival. It has a dual role in both acute and chronic inflammation, influencing leukocyte migration and macrophage function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Yuping Wang, Yang Gu, Xin Gu, Danielle B. Cooper, David F. Lewis
Summary: This study found that there is tubular injury in preeclampsia, which is indicated by increased levels of NGAL and KIM-1. The higher postpartum levels of NGAL and KIM-1 in preeclamptic pregnancies suggest that proper follow-up and management of kidney function is necessary to reduce chronic kidney diseases in these women later in life.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, Research & Experimental
Monika Kamianowska, Aleksandra Kamianowska, Anna Wasilewska
Summary: This study aimed to determine whether hyperuricemia influences the levels of urinary kidney injury markers in children and adolescents. The results showed that interleukin-18/cr. levels were significantly higher in the hyperuricemia group compared to the reference group, while KIM-1/cr. did not differ between the groups. The ratio of interleukin-18/cr. correlated positively with serum uric acid concentration.
ADVANCES IN MEDICAL SCIENCES
(2023)
Article
Chemistry, Medicinal
Mahmoud Elshal, Marwa E. Abdelmageed
Summary: The current study aimed to repurpose the anti-arthritic drug diacerein (DCN) for the treatment of acetaminophen-induced hepatotoxicity and investigate the underlying mechanisms. The results showed that DCN significantly reduced liver dysfunction, oxidative stress, hepatocyte necrosis, and inflammation, and inhibited acetaminophen-induced hepatocellular apoptosis. These effects were comparable to the existing treatment drug NAC.
ARCHIVES OF PHARMACAL RESEARCH
(2022)
Article
Immunology
Eva Poveda, Wendy Fitzgerald, Cristina Reglero, Alexandre Perez-Gonzalez, Ana Marino, Hortensia Alvarez, Nieves Valcarce, Josep Maria Llibre, Santiago Moreno Guillen, Maria Angeles Munoz Fernandez, Ezequiel Ruiz-Mateos, Leonid Margolis, Michael M. Lederman, Michael L. Freeman
Summary: Elite controllers (EC) had higher levels of plasma extracellular vesicle (EV)-associated cytokines compared to other people with HIV, and persistent controllers (PC) had higher levels than transient controllers (TC). EV-associated IL-18 could distinguish EC from ART-treated individuals, while EV-associated IL-3 and TRAIL could distinguish PC from TC. Further investigation is needed to understand the role of EV-cytokines in intercellular communication and endogenous control of HIV expression.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Pediatrics
P. Mangala C. S. De Silva, T. D. K. S. C. Gunasekara, S. D. Gunarathna, P. M. M. A. Sandamini, R. A. Pinipa, E. M. D. Ekanayake, W. A. K. G. Thakshila, S. S. Jayasinghe, E. P. S. Chandana, Nishad Jayasundara
Summary: This study aimed to determine reference intervals for KIM-1 and NGAL in a pediatric population in Sri Lanka affected by CKDu. The findings provide valuable information for screening and detecting early renal damage in rural communities impacted by CKDu.