Review
Medicine, General & Internal
Zihan Ding, Tsz-Lok Lee, Agnes S. Chan
Summary: The current systematic review aims to identify digital cognitive biomarkers from computerized tests for detecting dementia and mild cognitive impairment (MCI), and evaluates their diagnostic performance. Results showed that digital cognitive biomarkers achieved comparable or better diagnostic performance than traditional tests, and have the potential to be sensitive markers for MCI and dementia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Luisa Agnello, Bruna Lo Sasso, Matteo Vidali, Concetta Scazzone, Caterina Maria Gambino, Tommaso Piccoli, Giulia Bivona, Anna Maria Ciaccio, Rosaria Vincenza Giglio, Vincenzo La Bella, Marcello Ciaccio
Summary: This study evaluated cerebrospinal fluid (CSF) alpha-syn levels in different neurological disorders, showing that patients with Parkinson's Disease (PD) had the lowest levels while patients with Alzheimer's Disease (AD) had the highest levels. In AD patients, alpha-syn levels were significantly associated with tau proteins, suggesting alpha-syn could serve as a biomarker for neurodegenerative diseases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Jie Lin, Yexiang Zheng, Ying Liu, Yi Lin, Qiqi Wang, Xiao-Hong Lin, Wenli Zhu, Wei-Hong Lin, Ning Wang, Wan-Jin Chen, Ying Fu
Summary: This study suggests that plasma glial fibrillary acidic protein could serve as a biomarker for distinguishing neurological involvement in patients with Wilson disease.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Anniina Snellman, Juan Lantero-Rodriguez, Andreja Emersic, Agathe Vrillon, Thomas K. Karikari, Nicholas J. Ashton, Milica Gregoric Kramberger, Sasa Cucnik, Claire Paquet, Uros Rot, Henrik Zetterberg, Kaj Blennow
Summary: The study develops new N-terminal-directed CSF total tau assays, which show increased levels ahead of standard t-tau in the Alzheimer's disease continuum, higher levels in patients with CJD or acute neurological diseases, and better potential as Alzheimer's disease blood biomarkers compared to Quanterix total tau.
Review
Biochemistry & Molecular Biology
Vivek Kumar Sharma, Thakur Gurjeet Singh, Vineet Mehta, Ashi Mannan
Summary: Neurological disorders are a significant threat to social health and are responsible for high mortality and morbidity. Although drug development and therapy have improved, inadequate diagnosis and understanding of these disorders have hindered the effectiveness of treatment options. Biomarkers have been seen as a potential solution to the complexities of neurological disorders, providing insight into pathophysiology and guiding therapeutic interventions. However, challenges such as brain complexity, conflicting data, poor diagnostics, and high costs limit biomarker development. Research in this area is crucial for advancing our understanding and treatment of neurological disorders.
NEUROCHEMICAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Aladdin H. Shadyab, Linda K. McEvoy, Steve Horvath, Eric A. Whitsel, Stephen R. Rapp, Mark A. Espeland, Susan M. Resnick, JoAnn E. Manson, Jiu-Chiuan Chen, Brian H. Chen, Wenjun Li, Kathleen M. Hayden, Wei Bao, Cynthia D. J. Kusters, Andrea Z. LaCroix
Summary: The study examined the association between epigenetic age acceleration and cognitive impairment, finding that intrinsic AgeAccel was not significantly associated with cognitive impairment overall, but was associated with impairment among women who developed coronary heart disease.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Review
Clinical Neurology
Christian Barro, Henrik Zetterberg
Summary: NfL serves as a specific marker for neuronal injury, but lacks specificity for the cause or location of the damage, potentially indicating disease activity in neurological conditions. The utility of NfL in different diseases has been reviewed, revealing its universal nature as a marker of neuronal damage that extends beyond individual diseases, with potential benefits from considering the relationship between neurological symptoms and blood NfL levels.
ACTA NEUROLOGICA SCANDINAVICA
(2021)
Article
Clinical Neurology
Michelle H. Chen, Nancy D. Chiaravalloti, John DeLuca
Summary: Cognitive impairment is a common and disabling symptom in multiple sclerosis, with limited evidence supporting the efficacy of disease-modifying therapies in treating cognitive dysfunction. Cognitive rehabilitation in MS has shown promise in the past decade, with both restorative and compensatory programs proving efficacious. Clinicians should consider this low-cost, low-risk, yet effective treatment approach for their patients.
JOURNAL OF NEUROLOGY
(2021)
Article
Plant Sciences
Zhixin Wang, Yue Niu, Tripti Vashisth, Jingwen Li, Robert Madden, Taylor Shea Livingston, Yu Wang
Summary: A novel method combining UHPLC/MS-based nontargeted metabolomics and machine learning was developed for the early detection of HLB, achieving high accuracy and practicality.
HORTICULTURE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
David Vogrinc, Milica Gregoric Kramberger, Andreja Emersic, Sasa Cucnik, Katja Goricar, Vita Dolzan
Summary: Alzheimer's disease (AD) is a common neurodegenerative disease with a complex genetic background. Genome-wide association studies (GWAS) have identified numerous AD risk loci. This study aims to assess the associations between SNPs in well-established GWAS AD risk loci and CSF biomarker levels or cognitive test results in Slovenian patients with cognitive decline.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Lina Feng, Farooq Riaz, Kaikai Lu, Xiaona Cheng, Yanping Chen, Rong Zhao, Litao Wu, Shemin Lu, Dongmin Li
Summary: In this study, LAP3 was found to be significantly upregulated in the serum and hepatocytes of patients with NASH, and it was strongly correlated with clinical indicators of NASH. Therefore, LAP3 could be a promising serum biomarker candidate for NASH diagnosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Yan Wang, Ying Li, Yan Li, Tingting Li, Qi Wang, Qigeng Wang, Shuman Cao, Fangyu Li, Jianping Jia
Summary: This study selected four potential biomarkers and measured their plasma levels in patients with Alzheimer's disease and amnestic mild cognitive impairment, developing a composite panel for screening and diagnosing these two conditions.
BIOMARKER RESEARCH
(2023)
Review
Veterinary Sciences
Alessandra Gavazza, Andrea Marchegiani, Lorenza Guerriero, Vanessa Turinelli, Andrea Spaterna, Sara Mangiaterra, Livio Galosi, Giacomo Rossi, Matteo Cerquetella
Summary: Laboratory tests play an important role in cardiovascular diseases, with specific tests or biomarkers providing more information about myocardial damage. Traditional tests such as complete blood count, serum biochemistry, and coagulation can assist in patient investigation, but lack specificity.
VETERINARY SCIENCES
(2021)
Review
Genetics & Heredity
Xin Wan, Yiling Ge, Siyi Xu, Yanlu Feng, Yuxin Zhu, Lihong Yin, Yuepu Pu, Geyu Liang
Summary: This study systematically summarizes and discusses the latest findings on common m(6)A regulators, examining their expression, function, and mechanisms in neurodevelopment and neurological diseases. Additionally, it explores the potential of m(6)A modification in diagnosing and treating neurological disorders, aiming to provide new insights into the molecular mechanisms and potential therapeutic strategies for neurological disorders.
Article
Clinical Neurology
Emrah Duezel, Gabriel Ziegler, David Berron, Anne Maass, Hartmut Schuetze, Arturo Cardenas-Blanco, Wenzel Glanz, Coraline Metzger, Laura Dobisch, Martin Reuter, Annika Spottke, Frederic Brosseron, Klaus Fliessbach, Michael T. Heneka, Christoph Laske, Oliver Peters, Josef Priller, Eike Jakob Spruth, Alfredo Ramirez, Oliver Speck, Anja Schneider, Stefan Teipel, Ingo Kilimann, Wiltfang Jens, Bjoern-Hendrik Schott, Lukas Preis, Daria Gref, Franziska Maier, Matthias H. Munk, Nina Roy, Tomasso Ballarini, Renat Yakupov, John Dylan Haynes, Peter Dechent, Klaus Scheffler, Michael Wagner, Frank Jessen
Summary: This study investigated whether the impact of tau-pathology on memory performance and hippocampal/medial temporal memory function depends on the presence of amyloid pathology. The results showed a linear relationship between amyloid pathology, tau pathology, hippocampal dysfunction, and memory impairment.
Article
Medicine, General & Internal
Tasnime Akbaraly, Claire Sexton, Enika Zsoldos, Abda Mahmood, Nicola Filippini, Clarisse Kerleau, Jean-Michel Verdier, Marianna Virtanen, Audrey Gabelle, Klaus P. Ebmeier, Mika Kivimaki
AMERICAN JOURNAL OF MEDICINE
(2018)
Article
Neurosciences
Mireille Moussaed, Sylvaine Huc-Brandt, Nicolas Cubedo, Michele Silhol, Samy Murat, Marie-Christine Lebart, Gabor Kovacs, Jean-Michel Verdier, Francoise Trousse, Mireille Rossel, Anne Marcilhac
NEUROBIOLOGY OF DISEASE
(2018)
Article
Psychiatry
Fabrice Chimienti, Laurent Cavarec, Laurent Vincent, Nicolas Salvetat, Victoria Arango, Mark D. Underwood, J. John Mann, Jean-Francois Pujol, Dinah Weissmann
TRANSLATIONAL PSYCHIATRY
(2019)
Review
Neurosciences
Christelle Lasbleiz, Nadine Mestre-Frances, Gina Devau, Maria-Rosario Luquin, Liliane Tenenbaum, Eric J. Kremer, Jean-Michel Verdier
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2019)
Article
Oncology
Sebastien Dupasquier, Philippe Blache, Laurence Picque Lasorsa, Han Zhao, Jean-Daniel Abraham, Jody J. Haigh, Marc Ychou, Corinne Prevostel
Article
Neurosciences
N. Salvetat, S. Van der Laan, B. Vire, F. Chimienti, S. Cleophax, J. P. Bronowicki, M. Doffoel, M. Bourliere, R. Schwan, J. P. Lang, J. F. Pujol, D. Weissmann
JOURNAL OF NEUROVIROLOGY
(2019)
Article
Microbiology
Juan Castro-Severyn, Coral Pardo-Este, Yoelvis Sulbaran, Carolina Cabezas, Valentina Gariazzo, Alan Briones, Naiyulin Morales, Martial Seveno, Mathilde Decourcelle, Nicolas Salvetat, Francisco Remonsellez, Eduardo Castro-Nallar, Franck Molina, Laurence Molina, Claudia P. Saavedra
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Oncology
Amaelle Otandault, Jean-Daniel Abraham, Zahra Al Amir Dache, Abdelnaby Khalyfa, Isabelle Jariel-Encontre, Thierry Forne, Corinne Prevostel, Salem Chouaib, David Gozal, Alain R. Thierry
BRITISH JOURNAL OF CANCER
(2020)
Article
Psychiatry
Nicolas Salvetat, Fabrice Chimienti, Christopher Cayzac, Benjamin Dubuc, Francisco Checa-Robles, Pierrick Dupre, Sandie Mereuze, Vipul Patel, Catherine Genty, Jean-Philippe Lang, Jean-Francois Pujol, Philippe Courtet, Dinah Weissmann
Summary: The study found significant alterations in RNA editing of the PDE8A gene in the blood of patients with major depressive disorder and suicide attempters, suggesting a link to inflammation, cognition, and antidepressant treatment. Monitoring RNA editing in PDE8A in blood samples may help evaluate depressive state and suicide risk.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Microbiology
Boualem Sendid, Nicolas Salvetat, Helene Sarter, Severine Loridant, Catherine Cunisse, Nadine Francois, Rachid Aijjou, Patrick Gele, Jordan Leroy, Dominique Deplanque, Samir Jawhara, Dinah Weissmann, Pierre Desreumaux, Corinne Gower-Rousseau, Jean Frederic Colombel, Daniel Poulain
Summary: This study aimed to assess the effect of the antifungal fluconazole on post-operative recurrence of Crohn's disease. Results showed that fluconazole had an impact on the relationship between Candida albicans and Crohn's disease, but due to the limited sample size, no definitive conclusions could be drawn.
Article
Multidisciplinary Sciences
Francisco Santos Schneider, Laurence Molina, Marie-Christine Picot, Nicolas L'Helgoualch, Julien Espeut, Pierre Champigneux, Mellis Alali, Julie Baptiste, Lise Cardeur, Christophe Carniel, Martin Davy, Daniel Dedisse, Benjamin Dubuc, Hugo Fenech, Vincent Foulongne, Carole Fruchart Gaillard, Florence Galtier, Alain Makinson, Gregory Marin, Raissa Medina Santos, David Morquin, Alimata Ouedraogo, Alexandra Prieux Lejeune, Marine Quenot, Pierre Keiflin, Francisco Checa Robles, Carolina Rodrigues Rego, Nicolas Salvetat, Charline Trento, Diana Vetter, Franck Molina, Jacques Reynes
Summary: The study evaluated the diagnostic performance of a rapid, extraction-free and connected RT-LAMP assay on saliva for detecting SARS-CoV-2. The test showed high sensitivity and specificity, and performed similarly for symptomatic and asymptomatic individuals. No dominant mutation in the RT-LAMP primer region was observed. This reliable and simple connected test could facilitate the restart of professional and social events in the current economic context.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Brice Pastor, Jean-Daniel Abraham, Ekaterina Pisareva, Cynthia Sanchez, Andrei Kudriavstev, Rita Tanos, Alexia Mirandola, Lucia Mihalovicova, Veronique Pezzella, Antoine Adenis, Marc Ychou, Thibault Mazard, Alain R. Thierry
Summary: This study found that the degradation of neutrophil extracellular traps (NETs) contributes to the increased levels of circulating DNA (cirDNA) in patients with metastatic colorectal cancer (mCRC). These markers can distinguish between patients and healthy individuals and may have value in preventing thrombosis.
Article
Psychiatry
Nicolas Salvetat, Francisco Jesus Checa-Robles, Vipul Patel, Christopher Cayzac, Benjamin Dubuc, Fabrice Chimienti, Jean-Daniel Abraham, Pierrick Dupre, Diana Vetter, Sandie Mereuze, Jean-Philippe Lang, David J. Kupfer, Philippe Courtet, Dinah Weissmann
Summary: Using RNA editome analysis and machine learning, depressed patients with Bipolar Disorder (BD) can be identified, reducing the delay in misdiagnosis and allowing for earlier implementation of proper treatment.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Psychiatry
Mirian A. F. Hayashi, Nicolas Salvetat, Christopher Cayzac, Francisco Jesus Checa-Robles, Benjamin Dubuc, Sandie Mereuze, Joao V. Nani, Franck Molina, Elisa Brietzke, Dinah Weissmann
Summary: This study identified a panel of RNA editing-based blood biomarkers that can accurately distinguish bipolar disorder (BD) patients from unipolar depression patients, highlighting the diagnostic value of RNA editing in BD. The study also discovered new combinations of biomarkers that can effectively differentiate BD patients from healthy controls and subgroups within BD.
PSYCHIATRY RESEARCH
(2023)
