期刊
BIOMARKERS
卷 16, 期 8, 页码 629-636出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/1354750X.2011.608132
关键词
Esophageal tumor; microRNAs; cancer epigenetics; target gene; early diagnosis; genetherapy
资金
- Nanjing Health Bureau [ZKM06038, 3030708]
Esophageal carcinoma (EC) are characterized by dysregulation of microRNAs, which play an important roles as a posttranscriptional regulators in protein synthesis, and are involved in cellular processes, such as proliferation, apoptosis, and differentiation. Recently, altered miRNAs expression has been comprehensively studied in EC by high-throughput technology. Increased understanding of miRNAs target genes and their potential regulatory mechanisms have clarified the miRNAs activities and may provide exciting opportunities for cancer diagnosis and miRNA-based genetherapy. Here, we reviewed the most recently discovered miRNA target genes, with particular emphasis on the deciphering of their possible mechanisms and the potential roles in miRNAs-based tumour therapeutics.
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