期刊
BIOMARKERS
卷 14, 期 5, 页码 321-325出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/13547500902946757
关键词
Epidemiology; oxidative stress; chemotherapy
资金
- Duke Comprehensive Cancer Center
- NIH SPORE [5P50 CA68438]
- NATIONAL CANCER INSTITUTE [P50CA068438] Funding Source: NIH RePORTER
We used doxorubicin-based chemotherapy as a clinical model for oxidative assault. Study recruited 23 breast cancer patients and collected blood samples before (T0), at 1 (T1) and 24 hours (T24) after treatment administration. Measurements included protein carbonyl content (PPCC), malondialdehyde (MDA), and alpha- and gamma-tocopherols in plasma and total glutathione content in erythrocytes (erGSHt). In all subjects, PPCC and MDA levels did not change. erGSHt levels increased at T24 by 8% (p = 0.03). Levels of alpha, gamma, and total tocopherols progressively decreased by 7%-15% (p < 0.05). In subjects with low erGSHt levels (below median), PPCC mean levels progressively increased from 0.35 (T0) to 0.56 (T1) and 0.72 nmol carbonyl/mg protein (T24) (p = 0.2). These results indicate that (1) plasma MDA is not a sensitive biomarker in humans; (2) PPCC potentially may be used, if antioxidant reserves are taken into account; (3) antioxidant reserves play an important role in the reaction to oxidative stress.
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