期刊
BIOMARKERS
卷 13, 期 7-8, 页码 658-670出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/13547500802646572
关键词
Biomarker; cancer; microRNA; therapeutic drugs
资金
- Third-Term Comprehensive 10-Year Strategy for Cancer Control
- Ministry of Education, Culture, Sports, Science and Technology
- National Institute of Biomedical Innovation (NiBio)
- Takeda Science Foundation
MicroRNAs (miRNAs) are evolutionarily conserved, endogenous, noncoding small RNAs that act as post-transcriptional gene regulators. Experimental evidence has shown that miRNAs can play roles as oncogenes or tumor suppressor genes, suggesting their contribution to cancer development and progression. Expression profiles of human miRNAs demonstrated that many miRNAs are deregulated in cancers and are differentially expressed in normal tissues and cancers. Therefore, miRNA profiling is used to create signatures for a variety of cancers, indicating that the profile will help further establish molecular diagnosis, prognosis and therapy using miRNAs. This paper introduces the aberrant expression of miRNAs in human cancer, and discusses the potential of these miRNAs as biomarkers and targets/molecules for molecular therapy.
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