Article
Immunology
Anil K. Singh, Mahamudul Haque, Bhanupriya Madarampalli, Yuanyuan Shi, Benjamin J. Wildman, Abdul Basit, Sadik A. Khuder, Bhagwat Prasad, Quamarul Hassan, Salahuddin Ahmed, Madhu M. Ouseph
Summary: IL-6 trans-signaling induces molecular reprogramming of RASFs to osteoclast-like cells through the activation of transcription factor Ets2, leading to increased expression of osteoclast-specific proteins and markers of invasive phenotype.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Carolina Manosalva, Pablo Alarcon, John Quiroga, Stefanie Teuber, Maria D. Carretta, Hedie Bustamante, Rodrigo Lopez-Munoz, Maria A. Hidalgo, Rafael A. Burgos
Summary: Lameness in dairy cattle can be caused by infectious or noninfectious agents, with joint lesions being the second most common cause. Fibroblast-like synoviocytes (FLS) play a key role in joint diseases and the expression of proinflammatory mediators. Tumor necrosis factor-alpha (TNF-alpha) is a potent proinflammatory cytokine that increases the expression of proinflammatory cytokines in bovine FLS (bFLS). This study found that TNF-alpha induces metabolic reprogramming in bFLS, favoring glycolysis, and increasing the expression of IL-6, IL-8, IL-1 beta, and COX-2/PGE2.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Anais Mariscal, Carlos Zamora, Cesar Diaz-Torne, Ma Angels Ortiz, Juan Jose de Agustin, Delia Reina, Paula Estrada, Patricia Moya, Hector Corominas, Silvia Vidal
Summary: The binding of platelets to monocytes is increased in rheumatoid arthritis, and this interaction is modulated by IL-6 blockage. After treatment, the percentage of CD14+PLT+ increases in patients who achieve remission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Jinhai He, Li Wang, Yajun Ding, Hongbing Liu, Guoyou Zou
Summary: The study investigated the expression of lncRNA FER1L4 in OA and its potential as a diagnostic marker. The results showed that FER1L4 was downregulated in OA patients and could efficiently discriminate OA cases from normal subjects. Additionally, upregulation of FER1L4 inhibited IL-6 expression in human chondrocytes.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Piero Ruscitti, Vasiliki Liakouli, Noemi Panzera, Adriano Angelucci, Onorina Berardicurti, Elena Di Nino, Luca Navarini, Marta Vomero, Francesco Ursini, Daniele Mauro, Vincenza Dolo, Francesco Ciccia, Roberto Giacomelli, Paola Cipriani
Summary: This study found that the expression of markers of myofibroblast differentiation in the synovial tissue of rheumatoid arthritis patients was significantly higher than in healthy controls, and that TGF-beta and IL-6 stimulation promoted the expression of these markers; tofacitinib may have a role in reducing the expression of these markers.
Article
Immunology
Tae Sung M. Kim, Lakmali Silva, Vasileios Ionas Theofilou, Teresa Greenwell-Wild, Lu Li, Drake Winslow Williams, Tomoko Ikeuchi, Laurie H. Brenchley, Thomas I. Bugge, Patricia J. Diaz, Mariana Kaplan, Carmelo M. Carmona-Rivera, Niki Moutsopoulos
Summary: Neutrophil extracellular traps (NETs) are early triggers of pathogenic inflammation in periodontitis, a prevalent oral inflammatory disease. NETs promote IL-17/Th17 immune response and contribute to bone destruction. Human findings support the role of NET-mediated pathology in periodontitis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Immunology
Reiji Yamamoto, Satoshi Yamada, Toru Atsumi, Kaoru Murakami, Ari Hashimoto, Seiichiro Naito, Yuki Tanaka, Izuru Ohki, Yuta Shinohara, Norimasa Iwasaki, Akihiko Yoshimura, Jing-Jing Jiang, Daisuke Kamimura, Shintaro Hojyo, Shimpei Kubota, Shigeru Hashimoto, Masaaki Murakami
Summary: The IL-6 amplifier in synovial fibroblasts of F759 mice activates both STAT3 and NF-κB pathways, leading to immune cell infiltration and a disease similar to rheumatoid arthritis. The STAT3-NF-κB complex accumulates on NF-κB binding sites of the IL-6 promoter region, promoting inflammatory responses. Blocking IL-6 with antibodies can inhibit inflammation, even at later stages, while IL-17 and TNF-α antibodies do not have the same effect.
INTERNATIONAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Matthias Jarlborg, Cem Gabay
Summary: IL-6, produced in response to inflammation, induces systemic manifestations and plays a key role in the pathogenesis of rheumatoid arthritis. Blocking IL-6 not only affects joint inflammation, but also has various biological effects throughout the body.
Article
Biology
Cristina Almeida-Santiago, Juan Carlos Quevedo-Abeledo, Maria Vanesa Hernandez-Hernandez, Antonia de Vera-Gonzalez, Alejandra Gonzalez-Delgado, Miguel Angel Gonzalez-Gay, Ivan Ferraz-Amaro
Summary: This study aimed to analyze the linear correlation between IL-1ra and IL-6 in patients with rheumatoid arthritis (RA) and their relationship with disease's inflammatory activity. IL-6 and IL-1ra levels were measured in 407 RA patients. No correlation was found between serum levels of IL-6 and IL-1ra. However, both cytokines were positively associated with disease activity and acute phase reactants. After controlling for covariates, disease activity scores were more strongly associated with IL-1ra compared to IL-6.
Article
Biochemistry & Molecular Biology
Jihye Yoo, Darong Kim, Jiyoung Park, Young-Kook Kim, Hea-Young Park Choo, Hyun Ae Woo
Summary: Development of small molecule inhibitors for inflammatory cytokines is a promising strategy for treating inflammatory diseases like rheumatoid arthritis. The synthesized compounds demonstrated significant inhibitory activity on interleukins and their signaling pathways, showing potential for further development as small molecule inhibitors for RA.
Article
Rheumatology
Anella Saviano, Adel Abo Manosour, Federica Raucci, Francesco Merlino, Noemi Marigliano, Anna Schettino, Mussarat Wahid, Jenefa Begum, Andrew Filer, Julia E. Manning, Gian Marco Casillo, Marialuisa Piccolo, Maria Grazia Ferraro, Simona Marzano, Pasquale Russomanno, Rosa Bellavita, Carlo Irace, Jussara Amato, Mohammed Alfaifi, Peter Rimmer, Tariq Iqbal, Stefano Pieretti, Valentina Vellecco, Francesco Caso, Luisa Costa, Roberto Giacomelli, Raffaele Scarpa, Giuseppe Cirino, Mariarosaria Bucci, Helen M. McGettrick, Paolo Grieco, Asif Jilani Iqbal, Francesco Maione
Summary: This study identified a novel IL-17A/F-derived peptide and generated a new anti-IL-17 antibody that can effectively reverse the pro-inflammatory actions of IL-17A/F. The antibody showed less off-target effects compared to the current gold-standard biologic. Preclinical and clinical evidence demonstrated the high efficacy and therapeutic potency of the antibody in patients with IMIDs.
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Review
Cell Biology
Milena Iwaszko, Sylwia Bialy, Katarzyna Bogunia-Kubik
Summary: IL-4 and IL-13 are key mediators of allergic inflammation and have been implicated in the development of autoimmune diseases. Recent studies suggest that they may play a significant role in downregulating inflammatory processes underlying rheumatoid arthritis pathogenesis.
Review
Immunology
Yixin Zheng, Jianan Zhao, Yu Shan, Shicheng Guo, Steven J. Schrodi, Dongyi He
Summary: Rheumatoid arthritis (RA) is a complex autoimmune disease characterized by chronic inflammation in synovial tissues. Granzymes (Gzms) are serine proteases that enter target cells to induce programmed cell death. Increased levels of Gzms have been found in RA patients and they may contribute to inflammation by degrading extracellular matrix and promoting cytokine release. Although their exact role is yet to be fully understood, Gzms have the potential to be used as biomarkers for RA diagnosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Congqi Hu, Zhao Dai, Jia Xu, Lianyu Zhao, Yanping Xu, Meilin Li, Jiahui Yu, Lu Zhang, Hui Deng, Lijuan Liu, Mingying Zhang, Jiarong Huang, Linping Wu, Guangxing Chen
Summary: This study identified the serum marker ORM1 as a significant differential expression between normal and RA patient samples, positively correlated with disease activity, offering a new perspective for future research on RA.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Chemistry, Medicinal
Ayman M. Mahmoud, Ahmed M. Sayed, Osama S. Ahmed, Mohamed M. Abdel-Daim, Emad H. M. Hassanein
Summary: Rheumatoid arthritis is a chronic autoimmune disease affecting synovial joints, with interleukin-6 playing a significant role. Flavonoids, as plant metabolites with various pharmacological effects, exhibit anti-arthritic activity by suppressing pro-inflammatory cytokines.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Rheumatology
Dzenan Masic, Kristian Stengaard-Pedersen, Brian Bridal Logstrup, Kim Horslev-Petersen, Merete Lund Hetland, Peter Junker, Mikkel ostergaard, Christian Ammitzboll, Soren Moller, Robin Christensen, Torkell Ellingsen
Summary: In patients with rheumatoid arthritis, there were no significant differences in lipid level changes between those treated with adalimumab plus methotrexate and those treated with placebo plus methotrexate over a 1-year period. The study suggests that both treatment strategies have similar effects on lipid levels in early and treatment-naive RA patients.
RHEUMATOLOGY INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Kirsa Skov-Jeppesen, Nicola Hepp, Jannika Oeke, Morten Steen Hansen, Abbas Jafari, Maria Saur Svane, Nariman Balenga, John A. Olson, Morten Frost, Moustapha Kassem, Sten Madsbad, Jens-Erik Beck Jensen, Jens Juul Holst, Mette Marie Rosenkilde, Bolette Hartmann
Summary: The study found that GIP and meal intake can decrease bone turnover, and this effect was preserved in patients with hypoparathyroidism, suggesting that GIP may directly mediate bone turnover via GIPR. In contrast, the effect of GLP-2 on bone turnover appears to depend on changes in PTH and may be mediated through GLP-2R in the parathyroid gland.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Medicine, General & Internal
Julie R. Lundgren, Charlotte Janus, Simon B. K. Jensen, Christian R. Juhl, Lisa M. Olsen, Rasmus M. Christensen, Maria S. Svane, Thomas Bandholm, Kirstine N. Bojsen-Moller, Martin B. Blond, Jens-Erik B. Jensen, Bente M. Stallknecht, Jens J. Holst, Sten Madsbad, Signe S. Torekov
Summary: A strategy combining exercise and liraglutide therapy improved healthy weight loss maintenance more than either treatment alone. The combination strategy led to greater weight loss and improvements in metabolic health-related indicators.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Endocrinology & Metabolism
Signe Schmidt, Christian S. Frandsen, Thomas F. Dejgaard, Dorte Vistisen, Thorhallur Halldorsson, Sjudur F. Olsen, Jens-Erik B. Jensen, Sten Madsbad, Henrik U. Andersen, Kirsten Norgaard
Summary: Liraglutide treatment led to decreased fat and lean body mass, as well as reduced intake of added sugars, while no significant difference in total daily energy intake was observed between liraglutide- and placebo-treated participants.
DIABETES OBESITY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Sebastian Strom Ronnquist, Bjarke Viberg, Morten Tange Kristensen, Henrik Palm, Jens-Erik Beck Jensen, Carsten Fladmose Madsen, Kristina E. Akesson, Soren Overgaard, Cecilia Rogmark
Summary: Research on younger patients with hip fractures is limited. This study provides valuable knowledge about patient and injury characteristics, and explores the role of DXA in assessing bone mineral density at the time of fracture. Risk factors for osteoporosis and fractures were found to be abundant among young patients, with a much higher prevalence of osteoporosis compared to the general population.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Josephine Matzen, Lise Sofie Bislev, Tanja Sikjaer, Lars Rolighed, Mette Friberg Hitz, Pia Eiken, Anne Pernille Hermann, Jens-Erik Beck Jensen, Bo Abrahamsen, Lars Rejnmark
Summary: This study aimed to compare the effects of PTX and non-surgical surveillance on kidney function in pHPT patients. The findings showed that compared to non-surgical surveillance, PTX is associated with a small but significant decrease in kidney function in pHPT patients.
BMC ENDOCRINE DISORDERS
(2022)
Article
Endocrinology & Metabolism
Nicola Hepp, Lars Folkestad, Simone Mollebaek, Anja Lisbeth Frederiksen, Morten Duno, Niklas Rye Jorgensen, Anne Pernille Hermann, Jens-Erik Beck Jensen
Summary: This study aimed to evaluate bone turnover, bone strength and structure in adults with hypophosphatasia (HPP). The results showed that bone turnover markers did not differ between patients with HPP and reference individuals. Bone material strength index (BMSi) was not reduced in adults with HPP. However, patients with HPP had higher trabecular separation, inhomogeneity of trabecular network, and lower trabecular bone volume fraction. In addition, compound heterozygous adults with HPP had significantly higher cortical porosity.
Article
Endocrinology & Metabolism
S. E. Bonlokke, M. S. Rand, B. Haddock, S. Arup, C. D. Smith, J. E. B. Jensen, P. Schwarz, P. Hovind, P. S. Oturai, L. T. Jensen, S. Moller, P. Eiken, K. H. Rubin, M. F. Hitz, B. Abrahamsen, N. R. Jorgensen
Summary: Anti-resorptive osteoporosis treatment may be more effective in patients with high bone turnover, as indicated by biochemical markers. Pre-treatment levels of bone turnover markers can predict patients' response to antiresorptive treatment. Patients with high pre-treatment levels of CTX and/or PINP may benefit more from antiresorptive treatment with larger increases in BMD.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Nicola Hepp, Anja Lisbeth Frederiksen, Morten Duno, Niklas Rye Jorgensen, Jens-Erik Beck Jensen
Summary: HPP is a rare disease affecting bone mineralization, with adults having an increased occurrence of low-energy fractures and reduced physical performance compared to healthy controls.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Rheumatology
E. B. Rasmussen, L. S. Thiele, K. Stengaard-Pedersen, M. L. Hetland, K. Horslev-Petersen, P. Junker, M. Ostergaard, A. S. Hansen, M. Hvid, B. Deleuran, S. R. Greisen
Summary: ACPAs IgA and IgG have weak associations with disease activity in early RA, but are not superior in predicting long-term radiographic progression.
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Article
Endocrinology & Metabolism
John A. Kanis, Nicholas C. Harvey, Enwu Liu, Liesbeth Vandenput, Mattias Lorentzon, Eugene McCloskey, Roger Bouillon, Bo Abrahamsen, Lars Rejnmark, Helena Johansson
Summary: Patients with primary hyperparathyroidism have increased incidence of hip and major osteoporotic fractures, even if not referred for parathyroidectomy. The risk of death is also increased, which affects fracture probability. These findings support the need to widen the indications for parathyroidectomy in mild primary hyperparathyroidism.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Cardiac & Cardiovascular Systems
Rasmus M. Sandsdal, Christian R. Juhl, Simon B. K. Jensen, Julie R. Lundgren, Charlotte Janus, Martin B. Blond, Mads Rosenkilde, Adrian F. Bogh, Lasse Gliemann, B. Jensen Jens-Erik, Charalambos Antoniades, Bente M. Stallknecht, Jens J. Holst, Sten Madsbad, Signe S. Torekov
Summary: This study investigated the effects of exercise, a GLP-1 RA, or the combination on metabolic syndrome severity, abdominal obesity, and inflammation. The findings suggest that exercise, liraglutide treatment, or the combination can reduce the risk of cardiovascular disease and type 2 diabetes, as well as decrease the severity of metabolic syndrome, abdominal obesity, and inflammation.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sofie I. Halkjaer, Victoria E. de Knegt, Thomas Kallemose, Jens-Erik B. Jensen, Dina Cortes, Lise L. Gluud, Nicolai J. Wewer Albrechtsen, Andreas Munk Petersen
Summary: This study investigated the effect of probiotic supplementation during pregnancy on metabolic and inflammatory markers and body composition of offspring in pregnant women with obesity. The results showed that probiotic supplementation did not have a significant impact on these factors in mothers or babies. There were no differences found in measured biomarkers or newborn body composition between the probiotic and placebo groups.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Endocrinology & Metabolism
Felicia Cosman, Cesar Libanati, Cynthia Deignan, Zhigang Yu, Zhenxun Wang, Serge Ferrari, Jens-Erik Beck Jensen, Pilar Peris, Francesco Bertoldo, Eric Lespessailles, Eric Hesse, Steven R. Cummings
Summary: Increases in bone mineral density (BMD) are important for reducing fracture risk in osteoporosis treatment. This study compared the probabilities of achieving a T-score > -2.5 over 3 years with different treatment sequences in women with osteoporosis. Baseline BMD and the probability of achieving BMD goals are crucial factors in selecting initial treatment for osteoporosis patients. Starting treatment with romosozumab has higher likelihood of reaching BMD goals compared to alendronate when baseline T-scores are lower.
Article
Rheumatology
Morten Bilde Simonsen, Kim Horslev-Petersen, Maria C. Coster, Carsten Jensen, Ann Bremander
Summary: The prevalence of foot or ankle pain is high in patients with RA. The 12-joint foot count has minor effects on detecting patients with foot pain, while SEFAS can provide additional information on foot problems that may not be identified by joint examinations alone.
ACR OPEN RHEUMATOLOGY
(2021)