Article
Chemistry, Physical
Shringika Soni, Utkarsh Jain, Donald H. Burke, Nidhi Chauhan
Summary: Prescription stimulant drug (PSD) abuse is a global concern, and there is a need for the development of sensitive, rapid, and low-cost kits for on-spot PSD detection. In this study, a gold nanoflower modified, electrochemical aptasensor was successfully developed for Amphetamine (AMP) detection. The aptasensor showed high sensitivity, low limit of detection, and negligible interference from potentially interfering compounds. It was able to accurately detect AMP in spiked urine and water samples.
SURFACES AND INTERFACES
(2022)
Article
Electrochemistry
Rukiye Saygili-Canlidinc, Mustafa Oguzhan Caglayan, Ishak Afsin Kariper, Zafer Ustundag, Samet Sahin
Summary: A label-free impedimetric aptasensor for bisphenol A (BPA) was developed based on a novel method, using gold nanoparticle-based nanoplatforms and BPA-selective aptamer immobilization. The sensor showed good linearity, sensitivity, specificity, and stability, with a limit of detection of 8.6 fM and limit of quantification of 25.8 fM.
JOURNAL OF APPLIED ELECTROCHEMISTRY
(2023)
Article
Chemistry, Applied
Yukun Yang, Xiaoxing Zeng, Yu Tian, Xiaomin Wang, Xu Jing, Ligang Yu, Baoqing Bai, Jinhua Zhang, Shu Qin
Summary: A universal design of turn-on fluorescent aptasensor was developed for bisphenol A (BPA) detection, using aptamer functionalized gold nanoparticles (AuNPs) and luminescent metal-organic frameworks (LMOFs) complex (AuNPs-Apt/NH2-MIL-125(Ti)). The fabricated aptasensor exhibited a linear detection range of 1 x 10-9 mol L-1 to 1 x 10-4 mol L-1 with good selectivity, repeatability, stability, and reproducibility under optimal experimental conditions. Moreover, it showed successful application for BPA detection in real samples with high recoveries. This proposed aptasensor holds significant potential for BPA detection in environmental and food samples, contributing to the advancement of LMOFs-based aptasensors.
Article
Chemistry, Analytical
Cristina Tortolini, Anthony E. G. Cass, Riccardo Pofi, Andrea Lenzi, Riccarda Antiochia
Summary: The study introduces a microneedle-based sensor using highly nanoporous gold for continuous monitoring of catecholamines in interstitial fluid, displaying low detection limit, excellent sensitivity and stability, and fast response time. The performance of the sensor was evaluated in artificial interstitial fluid and a hydrogel skin model at typical physiological concentrations.
Article
Chemistry, Analytical
Liying Liu, Hao Yu, Qiang Zhao
Summary: This study thoroughly characterized the binding performance of a 60-nt anti-BPA DNA aptamer and successfully truncated it to a 29-nt DNA without losing affinity. With the truncated aptamer immobilized on a gold electrode, a reagent-less electrochemical aptamer-based sensor was developed for rapid BPA detection. The sensor showed quick response, selectivity, and the ability to detect BPA in complex samples.
Article
Chemistry, Multidisciplinary
Alex M. Downs, Julian Gerson, M. Nur Hossain, Kyle Ploense, Michael Pham, Heinz-Bernhard Kraatz, Tod Kippin, Kevin W. Plaxco
Summary: The spatial resolution of electrochemical aptamer-based sensors in the living body is limited by the length and width of the device's working electrode. By increasing the surface area of the electrodes using nanoporous gold, sensor miniaturization was achieved without compromising signal and response times. This fabrication technique is simple, parallelizable, and compatible with different electrode architectures, making it useful for various electrochemical biosensor applications.
Article
Engineering, Environmental
Jayaraman Theerthagiri, Seung Jun Lee, K. Karuppasamy, Juhyeon Park, Yiseul Yu, M. L. Aruna Kumari, Sivaraman Chandrasekaran, Hyun-Seok Kim, Myong Yong Choi
Summary: The research on gold nanostructures has been extensively documented over the last few decades, focusing on synthesizing and characterizing these structures for applications in environmental remediation and electrochemical sensing. Current studies are mainly centered on the utilization of gold nanostructures in these areas, as well as the detection methods for various target analytes and degradation of toxic contaminants.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemical Research Methods
Changtong Wu, Daria Barkova, Natalia Komarova, Andreas Offenhaeusser, Mariia Andrianova, Ziheng Hu, Alexander Kuznetsov, Dirk Mayer
Summary: An electrochemical aptamer-based sensor has been developed for glutamate, the major excitatory neurotransmitter in the central nervous system, with high selectivity and sensitivity, showing great potential for applications in microelectrodes and in vitro as well as in vivo monitoring of neurotransmitter release.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Analytical
Gilberto J. Silva Junior, Jessica Soares Guimaraes Selva, Anandhakumar Sukeri, Josue M. Goncalves, Matias Regiart, Mauro Bertotti
Summary: In this work, nanoporous gold (NPG) was prepared using three different approaches, with the combined method showing the most surface defects, largest electrochemical surface area, and highest sensitivity for the detection of methyl parathion. The NPG(A+B) sensor demonstrated excellent selectivity, reproducibility, and repeatability for MP detection, with a linear behavior in the concentration range of 5-50 ng mL(-1) and a low limit of detection (LOD) of 0.6 ng mL(-1).
Article
Chemistry, Analytical
Ayemeh Bagheri Hashkavayi, Byung Seok Cha, Sung Hyun Hwang, Jimin Kim, Ki Soo Park
Summary: An electrochemical aptasensor based on rolling circle amplification (RCA) and the catalytic ability of the hemin/G-quadruplex complex was developed for highly sensitive and selective detection of circulating tumor cells (CTCs). This strategy allows for the sensitive determination of target cancer cells down to a single cell with high selectivity even in human serum. The proposed platform with dual signal amplification shows promise for simple and ultrasensitive detection of CTCs, as well as other cancer cells and biomarkers in different clinical and biological samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Multidisciplinary
Lingli Zhang, Han Tao, Chun Ji, Qiaoling Wu, Xiao Wang, Yuangeng Wu
Summary: This paper presents a rapid and direct electrochemical sensing technique using hybrid MoS2 nanosheets and amino-functionalized carbon nanotubes for ultra-trace detection of bisphenol S (BPS). The method shows excellent sensitivity, fast response time, and reliability.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Applied
Liyuan Zhang, Jiayu Chen, Lifeng Lu, Runzhong Yu, Dongjie Zhang
Summary: A simple, fast, low-cost, sensitive, intuitive, visual, label-free, and smartphone-assisted aptamer sensor based on colorimetric assay was developed for measuring zearalenone in maize. The sensor utilized a nucleic acid aptamer as the recognition element and gold nanoparticles as the indicator. Various factors including aptamer and NaCl concentration, incubation time, and specificity were investigated. The results demonstrated a good linear relationship between the signal and zearalenone concentration (5-300 ng/mL) under optimal conditions, with a linear regression equation of Y = 0.0003X + 0.5128 (R2 = 0.9989) and a limit of detection of 5 ng/mL. The sensor exhibited good specificity and successfully measured zearalenone in maize samples, achieving recoveries of 81.3% - 96.4%. The entire process could be completed within 15 minutes. This smartphone-assisted colorimetric aptamer sensor holds promise for zearalenone detection in maize.
Article
Engineering, Environmental
Kuppusamy Rajesh, Deivasigamani Ranjith Kumar, P. Balaji Bhargav, R. Manigandan, Nafis Ahmed, C. Balaji, Jae-Jin Shim
Summary: A novel carbon dot-Vanadium pentoxide (C-dot-V2O5) nanoporous material was synthesized, and its incorporation of C-dot into the V2O5 lattice was confirmed. The fabricated C-dot-V2O5/GCE electrode showed high electrochemical surface area, uniform pore size, and electron transfer rate constant, enabling the detection of Bisphenol A (BPA) with high sensitivity.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Chemistry, Analytical
Jessica S. G. Selva, Anandhakumar Sukeri, Raphael P. Bacil, Silvia H. P. Serrano, Mauro Bertotti
Summary: The electrocatalytic activity of a platinum decorated nanoporous gold (Pt-NPG) surface toward the Hydrogen Oxidation Reaction (HOR) was examined using the feedback mode of Scanning Electrochemical Microscopy (SECM). The results showed that only when the substrate had excellent electrocatalytic activity to oxidize H2 back to H+, positive feedback current was observed. The NPG surface was found to be inactive for H2 oxidation, but became active after decoration with a small amount of Pt.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Cuixia Liang, Yumeng Wang, Tingting Zhang, Hailiang Nie, Yanmei Han, Jie Bai
Summary: This article introduces a "on-off-on" fluorescent sensor prepared using modified UiO-66, which can detect the content of BPS quickly and easily. The application of this sensor in commercial plastic bottled water has been validated.
Article
Chemistry, Analytical
Yujia Ying, Huilin Li
Summary: Enzymes play a crucial role as biological catalysts in accelerating biochemical reactions in living organisms. This study proposes a convenient method for monitoring enzymatic catalytic processes using native top-down mass spectrometry. By exploring the heterogeneity of the chymotrypsin sample and using tandem mass spectrometry, the researchers were able to monitor covalent and noncovalent enzymatic complexes, substrates, and products during catalysis. The results demonstrate that this method has the potential to be a promising tool for characterizing biocatalysts.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Kang Yang, Shuaibo Shi, Jinyu Wu, Shaolong Han, Shengdi Tai, Shishen Zhang, Kun Zhang
Summary: H2O and D2O are important analogues closely related to various industries and monitoring fields. This study successfully distinguishes and detects H2O and D2O by designing a novel eu(III)-macrocycle with dual emitters, Eu-2a, and conducting fluorescence titration experiments.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Julia Kuligowski, Alvaro Perez-Rubio, Marta Moreno-Torres, Polina Soluyanova, Judith Perez-Rojas, Ivan Rienda, David Perez-Guaita, Eugenia Pareja, Ramon Trullenque-Juan, Jose Castell, Marcha Verheijen, Florian Caiment, Ramiro Jover, Guillermo Quintas
Summary: This study introduces a novel variable selection approach called cluster PLS (c-PLS) to assess the joint impact of variable groups selected based on biological characteristics on the predictive performance of a multivariate model. The usefulness of c-PLS is shown using miRNomic and metabolomic datasets obtained from the analysis of liver tissue biopsies.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Meixue Lai, Lijie Zhong, Siyi Liu, Yitian Tang, Tingting Han, Huali Deng, Yu Bao, Yingming Ma, Wei Wang, Li Niu, Shiyu Gan
Summary: This study presents a method for constructing wearable sweat electrolyte sensors using carbon fiber-based solid-contact ion-selective electrodes (SC-ISEs). By using carbon fibers extracted from commercial cloth as electrode material, the cost and reproducibility issues of flexible SC-ISEs were addressed. The results showed that the carbon fiber-based SC-ISEs exhibited reversible voltammetric and stable impedance performances, and had high reproducibility of standard potentials between normal and bending states.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Yang, Ying Liu, Min Deng, Peipei Wang, Dan Cheng, Songjiao Li, Longwei He
Summary: A near-infrared fluorescent probe has been developed to accurately measure the levels of peroxynitrite (ONOO-) in the endoplasmic reticulum (ER) in acute lung injury (ALI). The probe demonstrated rapid response, high selectivity, good sensitivity, and enhanced fluorescence intensity in response to ONOO-. It was successfully used to detect changes in ONOO- levels and showed significant increases in an ALI cell model and an ALI mouse model.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yanping Wang, Yuemei Chen, Kejun Li, Jinrong Zhou, Xin Yuan, Mei Zhang, Ke Huang
Summary: In this work, a portable analytical system based on point discharge chemical vapor generation atomic emission spectrometry (PD-CVG-AES) coupling with gold filament enrichment was designed. The highly sensitive analysis of Hg2+ indirectly realized the detection of ascorbic acid (AA). The measurement is based on the fact that Ag+ can decrease the concentration of Hg2+ by forming Ag-Hg amalgam in the presence of the reductant SnCl2, while AA can pre-reduce Ag+ to Ag0, leading to the generation of silver nanoparticles (Ag NPs). The developed novel analytical strategy broadens the application of microplasma-based AES and offers a higher level of sensitivity compared to current AA detection techniques.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong, Jingli Yuan
Summary: This study developed two lysosome-targetable background-free TGL probes for efficient and accurate detection of 1O2, which can be used for monitoring endogenous 1O2 concentrations in lysosomes and discriminating variability induced by different photosensitizers. Furthermore, a smart luminescent sensor film was successfully prepared for on-site 1O2 production detection during PDT processes, offering a promising clinical monitoring tool for skin diseases.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Wei Lang, Jia-Mei Qin, Qian-Yong Cao
Summary: A novel polymer-based probe P1 was successfully synthesized for fluorescently ratiometric sensing of H2S with high selectivity and sensitivity. A smartphone sensing platform was constructed to conduct visual quantitative detection of H2S. P1 can be employed in evaluating the level fluctuations of H2S in living cells, testing water samples/wine samples, and monitoring food freshness.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Yuanyuan Qin, Shuda Liu, Shuyun Meng, Dong Liu, Tianyan You
Summary: The study developed a split aptamer-based sandwich-type ratiometric biosensor for the detection of 17 beta-estradiol (E2) using photoelectrochemical and electrochemical assays. The biosensor utilized split aptamer fragments to recognize E2 and trigger a hybridization chain reaction, resulting in the production of double-stranded DNA labeled with CdTe quantum dots. This DNA complex was able to sensitize CdTe quantum dots and generate response signals for E2 detection. The developed biosensor demonstrated high sensitivity and accuracy with two linear ranges and low detection limits.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Siriwan Teepoo, Jongjit Jantra, Khaunnapa Panapong, David Taiwo Ajayi
Summary: A novel immunochromatographic assay based on hyperbranched Au plasmonic blackbodies with a smartphone readout was developed for rapid and sensitive detection of leucomalachite green residues in fish and shrimp products.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Andrea L. Larraga-Urdaz, Borja Moreira-Alvarez, Jorge Ruiz Encinar, Jose M. Costa-Fernandez, Maria Luisa Fernandez-Sanchez
Summary: A major challenge in the 21st century is the development of point-of-care diagnostic tools. In this study, a highly sensitive and simple bioassay using AuNPs and MNAzymes was developed for rapid detection and quantification of miRNA-4739. The proposed strategy shows potential for breast cancer diagnosis.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Xiaohan Zhao, Anyu Wang, Lingzi Zhai, Jiuhe Gao, Sizhe Lyu, Yingshan Jiang, Tian Zhong, Ying Xiao, Xi Yu
Summary: A novel method using polystyrene-coated magnetic nanoparticles for extracting monohydroxy polycyclic aromatic hydrocarbons from urine samples was investigated. The proposed method is simple, sensitive, and efficient, with desirable sensitivity for analyzing low-abundance metabolites in large volumes of complex urine samples.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Ke Quan, Yuqing Zeng, Wenke Zhang, Fengfeng Li, Mengjiao Li, Zhihe Qing, Linlin Wu
Summary: In this study, a visual and reusable biosensor was developed for detecting substrates that are closely associated with human physiological health. The immobilized oxidase showed higher stability and sensitivity under harsh conditions, enabling reliable detection of substrates in complex fluids.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Dongjuan Wang, Xiuqian Ding, Jinling Xie, Juan Wang, Guanhao Li, Xin Zhou
Summary: In this study, a three-in-one sensor was developed for real-time detection of biogenic amines (BAs) with high sensitivity and selectivity. The sensor showed multimodal responses and could be used to fabricate portable devices for on-site non-destructive assessment of food spoilage indicators.
ANALYTICA CHIMICA ACTA
(2024)
Article
Chemistry, Analytical
Jinting Meng, Zihao Xu, Shasha Zheng, Hongqun Yang, Tianfu Wang, Hong Wang, Yingwei Zhang
Summary: This study demonstrates the development of a cascade signal amplification system using a multi-pedal DNA walker and strand displacement reactions for the electrochemical detection of miRNA-155. The biosensor exhibited high sensitivity, selectivity, and the potential for clinical applications.
ANALYTICA CHIMICA ACTA
(2024)