期刊
BIOMACROMOLECULES
卷 14, 期 2, 页码 350-357出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm3015285
关键词
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资金
- National Science Foundation [CHE-1112490, CHE-1048804]
- NIH Biotechnology Training Program [T32GM067555]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1112490] Funding Source: National Science Foundation
Hyperbranched glycopolymers containing mannose units in the branch point were synthesized through the copolymerization of a mannose inimer and mannose acrylate via atom transfer radical polymerization (ATRP). Incorporating a saccharide residue at the branch point results in a closer analogue to natural branched polysaccharides. Gel permeation chromatography characterization of the polymers qualitatively indicates branching in samples from polymerizations utilizing the mannose inimer. Deprotection of the acetate protecting groups from the hyperbranched mannose polymers yields water-soluble polymers that interact with mannose binding lectin (MBL), a key protein of the innate immunity complement system. MBL interaction increases with increasing polymer molecular weight and increasing branching density. Notably, incorporating mannose into the branching repeat unit also increases the interaction of the glycopolymers with MBL compared with glycopolymers with the same branching density but with no mannose at the branch point.
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