Article
Polymer Science
Ladislav Androvic, Lucie Woldrichova, Klaudia Jozefjakova, Michal Pechar, Geoffrey M. Lynn, Dana Kankova, Lenka Malinova, Richard Laga
Summary: A series of novel star polymer nanocarriers have been developed to improve the therapeutic effects of drugs, with suitable sizes for tumor uptake and programmable degradability.
Article
Chemistry, Multidisciplinary
Yueqiang Zhu, Yonghong Song, Ziyang Cao, Liang Dong, Yang Lu, Xianzhu Yang, Jun Wang
Summary: A large deformable polymeric nanocarrier, T-DA-PPED&F, was developed for efficient penetration and drug delivery into tumor tissue using magnetic actuation and pH-sensitive technology, showing significant anticancer effects.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Yunqiu Miao, Yuting Yang, Linmiao Guo, Mingshu Chen, Xin Zhou, Yuge Zhao, Di Nie, Yong Gan, Xinxin Zhang
Summary: This study presents the construction of nanocarriers that can mimic the biological and physical properties of red blood cells (RBCs) at different life stages. The nanocarriers demonstrated high immunocompatibility and superior antitumor efficacy compared to conventional chemotherapy drugs. The ability of the nanocarriers to deform and penetrate tumor tissues highlights their potential for future bionic design of nanomedicines.
Article
Pharmacology & Pharmacy
Peter Bitsch, Eva S. Baum, Irati Beltran Hernandez, Sebastian Bitsch, Jakob Harwood, Sabrina Oliveira, Harald Kolmar
Summary: In this study, nanobody dextran polymer conjugates (dextraknobs) loaded with small molecules were developed for cancer diagnostics and therapy. It was found that using smaller sized dextrans improved the homogeneous penetration of the conjugates into tumor spheroids. Additionally, the dextraknobs showed potent cell killing effects in photodynamic therapy. The monovalent nanobody conjugates exhibited deeper and more homogeneous penetration compared to the bivalent conjugates. These findings encourage further development of dextraknobs.
Article
Biochemistry & Molecular Biology
Chia-Ying Lee, Tsuimin Tsai, Po-Chun Peng, Chin-Tin Chen
Summary: In this study, doxorubicin-loaded lipid-based nanocarriers were developed using microfluidic technology based on electrostatic interaction. The nanocarriers showed high loading capacity and efficient drug release in an acidic environment. Different lipid compositions were optimized to achieve preferred drug release in acidic environments, leading to improved therapeutic efficacy compared to PEGylated liposomal doxorubicin in vivo.
Article
Chemistry, Multidisciplinary
Ceren Kimna, Theresa Monika Lutz, Hongji Yan, Jian Song, Thomas Crouzier, Oliver Lieleg
Summary: A nanoparticle-based drug delivery system has been designed to release therapeutic agents into disease cells based on specific DNA sequences, showing potential for targeted treatments of specific diseases.
Article
Chemistry, Applied
Qiaobin Hu, Yingjian Lu, Yangchao Luo
Summary: Dextran and its derivatives have attracted significant attention in the development of delivery systems for pharmaceutical and medical applications. Various dextran-based delivery systems have been developed with tailored properties and geometries, showing potential for diverse biomedical applications. Research focuses on the physicochemical properties of dextran, fabrication strategies, and their applications in biomedicine.
CARBOHYDRATE POLYMERS
(2021)
Article
Oncology
Jinxiang Liu, Jiaying Zhang, Yang Gao, Yuxuan Jiang, Zhenxin Guan, Yiying Xie, Jinghui Hu, Jing Chen
Summary: This review summarizes the barriers that limit the penetration of nanomedicines into tumors and proposes strategies to improve tumor permeation. Repairing abnormal tumor blood vessels and tumor stroma, as well as adjusting the physicochemical properties of nanoparticles, are considered promising approaches. The effects of nanoparticle properties, such as size, shape, and surface charge, on tumor penetration are also discussed. This review aims to provide research ideas and a scientific basis for enhancing intratumoral permeability and improving anti-tumor effects of nanomedicines.
Review
Chemistry, Multidisciplinary
Ningning Song, Jianlin Zhang, Jiao Zhai, Juanji Hong, Chang Yuan, Minmin Liang
Summary: Ferritins are spherical iron storage proteins composed of 24 subunits of heavy-chain ferritin (HFn) and light-chain ferritin (LFn), forming a hollow nanocage with unique nanocage structure. Human HFn shows potential for tumor-targeted delivery of various cargo molecules due to its intrinsic tumor-targeting property and unique nanocage structure.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Article
Chemistry, Physical
Liliana P. Alarcon, Heber E. Andrada, Maria E. Olivera, O. Fernando Silva, R. Dario Falcone
Summary: The study evaluates the interaction between catanionic vesicles based on amphiphilic cyclodextrins and DNA-Dox complex as a supramolecular anticancer drugs carrier. It reveals that the ModCBHD-DNA-Dox system exhibits slow-release properties and potential as an alternative carrier for chemotherapeutic agents.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Biophysics
Sylwia Michlewska, Zuzana Garaiova, Veronika Subjakova, Marcin Holota, Ma lgorzata Kubczak, Marika Grodzicka, Elzbieta Okla, Nikolaos Naziris, Lucja Balcerzak, Paula Ortega, Francisco Javier de la Mata, Tibor Hianik, Iveta Waczulikova, Maria Bryszewska, Maksim Ionov
Summary: In this study, we combined dendritic and liposomal carriers and analyzed the biochemical and biophysical properties of these formulations. Lipid-coated dendritic carriers showed significantly improved transfection profiles and lower toxicity to erythrocyte membranes compared to noncomplexed components. The nanometric size, low polydispersity index, and reduced positive zeta potential of these complexes make them attractive for future drug delivery applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Multidisciplinary Sciences
Yamei Liu, Ruirui Xing, Junbai Li, Xuehai Yan
Summary: Covalently triggered peptide self-assembly has been developed for cancer theranostics, providing enhanced stability and functionality compared to noncovalent interactions. The review summarizes the design principles for constructing various peptide-based assemblies and discusses representative covalently assembled peptide-based nanodrugs, along with their challenges and potential in clinical applications for cancer diagnosis and therapeutics. This review offers new insights into the construction of peptide-based nanodrugs through covalent reaction and noncovalent self-assembly.
Review
Chemistry, Physical
Xiaonan Fan, Xia Guo
Summary: Calixarenes as drug carriers have excellent properties such as easy functionalization, multiple loading sites for drugs, and responsiveness to external stimuli. They can effectively load various drugs and facilitate sustained drug release. Additionally, the introduction of metal/metal oxides into calixarene-based drug carriers further improves therapeutic effects.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Ying Zhou, Long Wang, Lufei Chen, Wei Wu, Zhimin Yang, Yuanzhuo Wang, Anqi Wang, Sujun Jiang, Xuzhen Qin, Zucheng Ye, Zhiyuan Hu, Zihua Wang
Summary: This article introduces a new drug delivery system, Exo@TDPs, which is developed by engineering glioblastoma cell-derived exosomes with improved biosafety. It demonstrates that Exo@TDPs can successfully penetrate the blood-brain barrier, target glioblastoma cells, and effectively release therapeutic drugs, resulting in the suppression of tumor growth and prolonged survival time in mouse models.
Article
Chemistry, Applied
Hong Deng, Xue Yang, Huimin Wang, Menghan Gao, Yiyi Zhang, Runmeng Liu, Haiyan Xu, Weiqi Zhang
Summary: This study demonstrates the potential of positively charged dextran nanogels (NGs) as a promising approach for TAM targeting in cancer therapy. By utilizing a non-covalent self-assembly strategy, the researchers constructed oppositely charged NGs and compared their effects on TAM targeting. The positive NGs showed superior TAM targeting in a murine breast cancer model.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Multidisciplinary
Kenward Jung, Nathaniel Corrigan, Edgar H. H. Wong, Cyrille Boyer
Summary: Synthetic polymers are widely used in society for various applications, while natural polymers are essential for life and environmental adaptation. Recent advancements in synthetic polymerization techniques have led to the development of bioactive synthetic polymers with specific biological functions, opening up new opportunities for biomedical applications.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Valentin A. Bobrin, Kenny Lee, Jin Zhang, Nathaniel Corrigan, Cyrille Boyer
Summary: A novel approach for fabricating materials with controlled nanoscale morphologies using Digital Light Processing 3D printing technique has been demonstrated. This method utilizes reversible deactivation radical polymerization to control the microphase separation of printing resins, resulting in materials with enhanced mechanical properties.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Zhiheng Zhang, Nathaniel Corrigan, Cyrille Boyer
Summary: In this study, RAFT agents were incorporated into resin formulations to allow for visible light-mediated 3D printing of materials with self-healing capabilities. The self-healing process is based on the reactivation of RAFT agent embedded in the thermosets under UV light, enabling reformation of the polymeric network. Resins containing RAFT agents enable 3D printing of thermosets with self-healing properties, expanding the potential applications in various fields.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Chenyu Wu, Nathaniel Corrigan, Chern-Hooi Lim, Wenjian Liu, Garret Miyake, Cyrille Boyer
Summary: The use of photocatalysts in controlled polymerization has provided new opportunities for sophisticated macromolecular synthesis. The rational design of photocatalysts based on the knowledge of structure-property-performance relationships allows for rapid and economic tuning of the performance and functionality of polymerization systems, thus advancing polymer science.
Article
Biochemistry & Molecular Biology
Sharon L. Wong, Nikhil T. Awatade, Miro A. Astore, Katelin M. Allan, Michael J. Carnell, Iveta Slapetova, Po-Chia Chen, Jeffry Setiadi, Elvis Pandzic, Laura K. Fawcett, John R. Widger, Renee M. Whan, Renate Griffith, Chee Y. Ooi, Serdar Kuyucak, Adam Jaffe, Shafagh A. Waters
Summary: This study investigated the structural and functional defects of the rare CFTR mutation R352Q in cell models of the airway and gut. The mutation showed residual CFTR function, which could be restored by CFTR potentiators but not the corrector. Molecular dynamics simulations indicated a chloride conductance defect rather than a gating defect. The combination of in vitro patient-derived cell models and in silico simulations can improve predictions of modulator response and aid in CF precision medicine.
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Meike N. Leiske, Zihnil A. I. Mazrad, Aykut Zelcak, Kanu Wahi, Thomas P. Davis, Joshua A. McCarroll, Jeff Holst, Kristian Kempe
Summary: This study presents a method for synthesizing new amino acid-containing, cell-specific, therapeutically active polymers. Starting materials were amino acids, which were used to prepare tailored polymers with different amino acids in the side chain. The reversible addition-fragmentation chain-transfer (RAFT) polymerization of acrylate monomers resulted in polymers with narrow size distribution. Glutamate-functionalized, zwitterionic polymers exhibited high cytocompatibility and cellular specificity, showing association with cancer cell lines but not with nontumor fibroblasts. Cellular uptake experiments and confocal laser scanning microscopy confirmed energy-dependent uptake mechanisms and localization of the polymers in cellular lysosomes. Copolymers with a specific monomer ratio of Glu acrylate and BzlSer acrylate demonstrated targeted cytotoxicity against cancer cells while leaving fibroblasts unaffected. These results highlight the importance of incorporating biologically derived materials in synthetic polymers and the potential of zwitterionic, amino acid-derived materials for cellular targeting.
Article
Engineering, Biomedical
Z. Ma, S. W. Wong, H. Forgham, L. Esser, M. Lai, M. N. Leiske, K. Kempe, G. Sharbeen, J. Youkhana, F. Mansfeld, J. F. Quinn, P. A. Phillips, T. P. Davis, M. Kavallaris, J. A. McCarroll
Summary: The study demonstrated that star-shaped siRNA nanoparticles can effectively inhibit target gene expression in lung cancer cells and delay tumor growth in mouse lung tumors. This provides a proof-of-concept for aerosol delivery of star-siRNA nanoparticles as a novel therapeutic strategy to inhibit lung tumor growth.
Article
Engineering, Biomedical
Rocco Latorre, Paulina D. Ramirez-Garcia, Alan Hegron, James L. Grace, Jeffri S. Retamal, Priyank Shenoy, Mai Tran, Luigi Aurelio, Bernard Flynn, Daniel P. Poole, Rafael Klein-Cloud, Dane D. Jensen, Thomas P. Davis, Brian L. Schmidt, John F. Quinn, Michael R. Whittaker, Nicholas A. Veldhuis, Nigel W. Bunnett
Summary: Stable star polymer nanostars that release antagonists continuously for 24 hours provide effective and long-lasting relief from chronic pain by disrupting endosomal signaling.
Article
Chemistry, Physical
Matthew C. Urquhart, Francesca Ercole, Andrew J. Clulow, Thomas P. Davis, Michael R. Whittaker, Ben J. Boyd, John F. Quinn
Summary: This study discovers that an amphiphilic trisulfide can alter the behavior of lipid particles and enable triggered release of H2S, providing potential applications in stimuli-responsive drug delivery systems.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Polymer Science
John R. Finnegan, Thomas P. Davis, Kristian Kempe
Summary: Poly(2-oxazoline)s (POx) are promising biomaterials with biocompatibility and versatile functionality. This study successfully prepared POx nanorods of tunable length using a heat-induced living crystallization-driven self-assembly (CDSA) method and examined the essential steps of this process. The disassembly and freeze-drying protocols of the POx nanorods were also investigated.
Article
Chemistry, Physical
Yilin He, Haoyu Wang, Zhao Sha, Cyrille Boyer, Chun-Hui Wang, Jin Zhang
Summary: This work presents a new approach for hybridizing nano-scale materials to create Schottky junctions and enhance the electrical output of flexible triboelectric nanogenerators. By introducing a combination of conductive silver nanowires and perovskite oxide Mn-doped nanocrystals into the electrospun nanofibers, a significant increase in output power was achieved.
Article
Cell Biology
Ivan Lukmantara, Fang Chen, Hoi Yin Mak, Armella Zadoorian, Ximing Du, Fanqian Nicole Xiao, Dougall MacMurray Norris, Elvis Pandzic, Renee Whan, Qing Zhong, Hongyuan Yang
Summary: In this study, we identified PI(3)P as a novel regulator of lipid droplet (LD) biogenesis, which impacts LD formation and lipidation through DFCP1. Disruption of cellular PI(3)P homeostasis affects the normal function and localization of DFCP1.
MOLECULAR BIOLOGY OF THE CELL
(2022)
Article
Health Care Sciences & Services
Sharon L. Wong, Elvis Pandzic, Egi Kardia, Katelin M. Allan, Renee M. Whan, Shafagh A. Waters
Summary: Infection control and antibiotic therapy are crucial for managing airway infections in patients with cystic fibrosis. The use of airway epithelial cell cultures grown at air-liquid interface (ALI) provides a physiologically relevant model for studying respiratory infections. Immunofluorescence staining and imaging are effective tools for understanding host-pathogen interactions and exploring potential treatments. A quantitative fluorescence microscopy assay using a graphical user interface (GUI) package is described for identifying specific cell populations and pathogen targets in ALI cultures.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Materials Science, Biomaterials
Paulina D. Ramirez-Garcia, Nicholas A. Veldhuis, Nigel W. Bunnett, Thomas P. Davis
Summary: In this article, we propose a new opportunity to target intracellular compartments by delivering antagonists via nanoparticles to G-protein coupled receptors. We specifically discuss the application of this approach in antagonizing endosomal receptors involved in pain for developing long-lasting analgesics, and also highlight the potential broader applications. We also discuss the materials used and provide design requirements for future successful applications.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Review
Chemistry, Multidisciplinary
Nicholas Andrikopoulos, Huayuan Tang, Yue Wang, Xiufang Liang, Yuhuan Li, Thomas P. Davis, Pu Chun Ke
Summary: Therapeutic peptides are important drugs that specifically target abnormal protein-protein interactions associated with amyloid diseases. The use of nanoparticles in combination with peptide drugs has emerged as a promising strategy for enhancing their efficacy against amyloid aggregation and cellular inflammation. However, there is still a lack of understanding of the chemistry and function of peptido-nanocomposites, and a systematic analysis of their application against a range of amyloid pathogeneses is missing.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
