期刊
BIOMACROMOLECULES
卷 13, 期 11, 页码 3427-3438出版社
AMER CHEMICAL SOC
DOI: 10.1021/bm301220k
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资金
- Hearing Health Foundation
- National Institutes of Health [NIDCD T32 DC00011]
There is little remedy for the devastating,effects resulting from neuronal loss caused by neural injury or neurodegenerative disease. Reconstruction of damaged, neural circuitry with stem cell-derived neurons is a promising approach to repair these defects, but controlling differentiation and guiding synaptic integration with :existing neurons remain significant unmet Challenges. Biomaterial surfaces can present nanoscale topographical Cues that influence neuronal differentiation and process outgrowth: By combining these scaffolds with additional molecular biology strategies, synergistic control over,cell fate can be achieved: Here, we review recent progress in promoting, neuronal fate using techniques at the interface of biomaterial:science and genetic engineering. New data demonstrates that combining nanofiber topography With an induced genetic program. enhances neuritogenesis in a synergistic. fashion: We propose combining patterned biomaterial surface cues with prescribed genetic programs to achieve neuronal cell fates: with the desired sublineage specification, neurochemical profile, targeted integration, and electrophysiological properties.
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