Article
Chemistry, Physical
Xiaoting Peng, Jiachen Hao, Wenwen Tao, Diange Guo, Tiantian Liang, Xuelei Hu, Hai Xu, Xinglong Fan, Cuixia Chen
Summary: In response to the increasing incidence of melanoma, we have designed a self-assembling peptide that is activated by tyrosinase and exhibits toxicity to melanoma cells, leading to apoptosis. This design effectively inhibited melanoma growth in a mouse model with minimal side effects.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Pharmacology & Pharmacy
Debin Zheng, Jingfei Liu, Limin Xie, Yuhan Wang, Yinghao Ding, Rong Peng, Min Cui, Ling Wang, Yongjie Zhang, Chunqiu Zhang, Zhimou Yang
Summary: An enzymatic self-assembly strategy using the peptide F-pY-T was developed to induce mitochondrial oxidative stress in cancer cells, leading to immunogenic cell death (ICD) and enhanced immune responses. Combination therapy with anti-PD-L1 agents further improved the immunotherapeutic capacity without biotoxicity in major organs.
ACTA PHARMACEUTICA SINICA B
(2022)
Editorial Material
Biochemistry & Molecular Biology
Yupeng Wang, Feng Shao
Summary: The study identified NINJ1 as a mediator of plasma membrane rupture following programmed cell death, challenging the previous notion that this event was passive.
Article
Nanoscience & Nanotechnology
Yuqi Ma, Anhe Wang, Jieling Li, Qi Li, Qingquan Han, Yafeng Jing, Xuefang Zheng, Hongyu Cao, Xuehai Yan, Shuo Bai
Summary: The self-assembling behavior of peptides and derivatives plays a crucial role in constructing architectures and achieving specific functions in nature. However, the surface or interfacial self-assembly, especially on micro- or nanoparticles, has been less systematically studied. In this study, uniform porous CaCO3 micro particles with different surfaces were used to investigate the self-assembling behavior of dipeptides with various sequences. The experimental results showed that dipeptides with a negative charge preferentially self-assembled on the hydrophobic and positively charged surface of CaCO3 particles, and dipeptides with high Log p values had a significant effect on the self-assembling behavior on the surface of porous CaCO3.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Feng Guo, Junfeng Ke, Zhengdong Fu, Wenzhao Han, Liping Wang
Summary: Cell penetrating peptides (CPPs) are peptides capable of adapting to cell membranes and entering cells directly, often linked to nanocarriers for increased permeability. A specific 18-amino acid sequence has shown high gene transduction efficiency and biocompatibility, with potential applications in cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Jingjing Han, Haoning Gong, Xiaokang Ren, Xuehai Yan
Summary: This article introduces the research field of peptide-based supramolecular nanozymes, emphasizing the importance and versatility of peptides as building blocks, as well as the potential for regulating catalytic performance.
Article
Biochemistry & Molecular Biology
Fang-Yi Wu, Hsin-Chieh Lin
Summary: Synthetic bioactive aromatic peptide amphiphiles are recognized as key elements of emerging biomedical strategies due to their biocompatibility, design flexibility, and functionality. We investigated the self-assembly driving force of two supramolecular materials and found ordered π-π interactions and secondary structures in both compounds. In cell experiments, PFB-IKVAV showed promise as a potential supramolecular biomaterial for biomedical applications.
Article
Chemistry, Multidisciplinary
Ruo-Chen Guo, Xue-Hao Zhang, Peng-Sheng Fan, Ben-Li Song, Zhi-Xiang Li, Zhong-Yu Duan, Zeng-Ying Qiao, Hao Wang
Summary: A novel in vivo self-assembly strategy is developed to induce phase separation of cell membrane, improving the internalization of therapeutic peptides and enhancing drug delivery efficacy, particularly in cancer therapy.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Multidisciplinary Sciences
Wenguang Yang, Wenjia Liu, Xiang Li, Jin Yan, Wangxiao He
Summary: A mild and simple self-assembly strategy was developed for the construction of peptide-derived chiral supramolecular nanomedicine with suitable pharmaceutical properties. The study demonstrated the potential of chiral supramolecular nanomedicine in suppressing tumor progression and enhancing tumor immunotherapy.
JOURNAL OF ADVANCED RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Dingze Mang, Sona Rani Roy, Qizheng Zhang, Xunwu Hu, Ye Zhang
Summary: This study developed HS-instructed self-assembling peptides to inhibit cancer cell migration by hindering the binding of HSPG with HBEGF, leading to the suppression of FAK and ERK activation. This approach shows promise as a synthetic therapeutic strategy for targeted cancer migration inhibition.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
Ziv Azoulay, Polina Aibinder, Ayala Gancz, Jacob Moran-Gilad, Shiri Navon-Venezia, Hanna Rapaport
Summary: FKF, a tripeptide with potential antimicrobial activity, forms a pure peptide hydrogel phase made of natural amino acids. The hydrogel exhibits bactericidal activity against E. coli and P. aeruginosa, and reduces P. aeruginosa contamination in a rat skin lesion model.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
Man-Di Wang, Da-Yong Hou, Gan-Tian Lv, Ru-Xiang Li, Xing-Jie Hu, Zhi-Jia Wang, Ni-Yuan Zhang, Li Yi, Wan-Hai Xu, Hao Wang
Summary: PDC drugs offer advantages of improved drug targetability and reduced adverse effects compared to traditional chemotherapy, but their poor permeability to tumor cells needs to be addressed. The designed PDC drug molecule forms nanoclusters upon binding cellular receptor, enhancing treatment efficacy. This strategy leverages assembly principles to promote peptide penetration into cells and increase intracellular drug bioavailability.
Article
Dentistry, Oral Surgery & Medicine
Isaac Jordao de Souza Araujo, Gustavo Narvaes Guimaraes, Renato Assis Machado, Luiz Eduardo Bertassoni, Robert Philip Wynn Davies, Regina Maria Puppin-Rontani
Summary: The self-assembling peptide P-11-4 has been found to have comparable mineral deposition and odontoblast cell migration abilities as the native protein DMP1, making it a promising bioinspired molecule for studies on dentin bridge formation in pulp-capping strategies.
JOURNAL OF DENTISTRY
(2022)
Article
Infectious Diseases
Oktawian Stachurski, Damian Neubauer, Aleksandra Walewska, Emilia Ilowska, Marta Bauer, Sylwia Bartoszewska, Karol Sikora, Aleksandra Hac, Dariusz Wyrzykowski, Adam Prahl, Wojciech Kamysz, Emilia Sikorska
Summary: This study investigates short cationic antimicrobial lipopeptides with a high propensity to fibrillate, which exhibit high activity and stability on bacterial membranes, and low cytotoxicity against human cells. The findings suggest that monomers are the main active form and the target of action of the lipopeptides is the bacterial membrane.
Article
Chemistry, Physical
Fengyi Cao, Gangqing Ma, Meng Song, Genxing Zhu, Lin Mei, Qi Qin
Summary: Antimicrobial peptides with hydrophobic and cationic residues can self-assemble into hydrogels, and the number of residues affects the self-assembly behavior and structure characteristics. A strong crosslinked structure may have negative effects on antimicrobial activity.